Ribavirin hemolysis

Common Questions and Answers about Ribavirin hemolysis


233616 tn?1312790796 Then, 10 mL blood was collected into a heparinized Vacutainer tube at each time point. To minimize the possibility of hemolysis, ribavirin samples were drawn using a large bore catheter collected into a syringe. The needle was removed, and the contents of the syringe were gently released into an uncapped heparinized Vacutainer. The blood tubes were capped.
8683847 tn?1410760916 "Curious what the Ribavirin addresses........" http://en.wikipedia.org/wiki/Hepatitis_C_virus "Hepatitis C virus (HCV or sometimes HVC) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus ." http://en.wikipedia.org/wiki/RNA "RNA viruses have genomes composed of RNA that encodes a number of proteins.
Avatar f tn Bingo - so the Procrit is stimulating the the production of rbc and raising the hemoglobin. The ribavirin is causing the hemolysis which is resulting in higher blood ammonia levels - which is likely the reason he has been having these episodes of HE weekly lasting several days. So now the problem is what do we do? Dr said he does not need procrit this week as his hmg is at 11.4. That's great.
180992 tn?1383377657 06Feb blood draw results VL 81 HCV RNA PCR Tagman 2.0 ALT 32(Normal) AST Hemolysis(guess it clotted so no result) 1 week on 7985(that is what the pill says on it) combo pill result remarkable Starting VL 19,700,000 down to 81 woohooooo....
Avatar m tn For instance, I had Hepatitis C and treated with interferon and ribavirin. Interferon/ribavirin can cause hemolytic anemia - it did in my case - whereby the hemoglobin drops, the red blood cell count drops and as a consequence of the increased red blood cell destruction the indirect bilirubin can become elevated. In that case it is drug induced hemolytic anemia and once the drugs are stopped the lab values generally return to normal.
Avatar m tn The most frequent side effect of ribavirin is hemolytic anemia, which occurs in up to one-third of patients. Ribavirin causes hemolysis because ribavirin triphosphate is concentrated by erythrocytes. ..... During treatment with ribavirin, bilirubin and uric acid levels increase in about 10%–25% of patients. These side effects disappear 4–7 weeks after discontinuation of therapy." http://www.annalsofhepatology.com/old/PDF/vol5s1/Hp06S1-19.
Avatar n tn Yes, Procrit works for hemolytic anemia, which is a common side effect of riba. What your doctor says may be technically correct but not very relevant to hep c treatment. There's "hemolysis" and there's ribavirin induced hemolytic anemica. Big difference. Procrit has made a big difference in my treatment. Take it, you'll like it.
Avatar n tn Ribavirin is renally excreted, and if there is impaired renal function, ribavirin blood levels are higher and hemolysis is greater. This is a population in which viramidine might be of some use. If creatinine levels are greater than 2 times the upper limit of normal, ribavirin is generally not used. A reduced dose of ribavirin has been used in some patients with creatinine levels less than 2 times the upper limit of normal.
Avatar f tn The ribavirin is what is causing your aunt's anemia, no food or supplements are going to help, as said above you need to talk to your aunt's doc and come up with a plan, which will either be lowering her riba dosage or administering rescue drugs, at 8.5 it really needs to be dealt with ASAP What is Hemolytic Anemia? Your bone marrow is responsible for producing red blood cells, white blood cells, and platelets (cells responsible for clotting).
2065676 tn?1331426040 Yeah, lots of times, people who have a hard time clearing this virus, will also notice that their HGB isn't going down, also. One poster on here told me his Doctor upped his Ribavirin , until it gave him (hemolytic) anemic, because he wasn't able to clear the virus, until the Riba knocked his HGB down....
Avatar m tn With use of higher doses of ribavirin (1000-1200 mg/d), hemoglobin levels frequently decline by 2-3 g/dL, as seen in this case. In addition to causing hemolysis, ribavirin can also down-regulate the number of erythropoietin receptors.
264121 tn?1313033056 My doctor (hematologist) also gave me IV gammaglobulin with the transfusion this time, it is supposed to help stop the hemolysis from the ribavirin. He also gave me steroids that he wants me to continue at 40mg day but I am afraid to do so before conducting an HCV expert as there are various ideas about whether steroid use might sabotage HCV treatment. Prednisone would probably help my hemolysis and thus help me tolerate tx better is the reason he wants me on it.
Avatar m tn the A1c test results can be rendered inaccurate due to increased hemolysis from ribavirin. Another test you might want to consider would be a glucose tolerance test; this is a simple test offered be almost any lab that involves establishing a baseline fasting glucose result, then having the patient ingest a known quantity of glucose in solution. Serum glucose samples are then collected at specified intervals to determine the rate of glucose metabolism.
Avatar m tn You are a geno 3 and, if I understand it correctly, were not undetectable even by week 12? What do you mean with "conventional" interferon? Are you treating with ribavirin as well? How long are you planning to treat? What country do you live in? As a geno 3, you need to be undetectable preferably at week 4, but at the latest at week 12. If not undetectable until somewhere between week 5 and 12, you need to treat for 48 weeks to up your chances of SVR.
87972 tn?1322664839 Viramidine, a prodrug of ribavirin that specifically targets the liver, is associated with less hemolysis than ribavirin, and in preliminary clinical studies, seems to have similar efficacy.10 Levovirin, the L-enantiomer of ribavirin, has been disappointing thus far in clinical trials but higher doses have not been tested.11 The apparent increase in effectiveness of high-dose ribavirin over standard dose is intriguing from a mechanistic view.
442340 tn?1326821017 Hi All, I haven't posted in a while because I have been "adjusting" to Tx. First three weeks not bad at all (minor sides) but this last week my Hemoglobin went from 14.5-11.1 and then today dropped to 10.0. I feel weak, dizzy, and like I'm sucking air! So my nurse called and I have to see a hemotologist on Monday for "rescue drugs." (Will I make it till Monday?) She also reduced my Ribavirin to 800 mg instead of 1000. Will that affect my Tx results?
Avatar f tn Decreases in the hemoglobin level and increases in the bilirubin level were seen in the two groups that received the ribavirin-containing regimen — findings consistent with ribavirin-mediated hemolysis — but not in the two groups that received ledipasvir–sofosbuvir alone.
Avatar m tn I'm on ribavirin. I have read on here that lower red cell is a good thing. I've boosted my b-12 dosage, meat, egg yolk, bean, leafy green intake to help keep mine up. am I helping or hurting my recovery by trying to keep red cell count \ up?
Avatar n tn Viramidine is taken up by the liver to a much larger degree than is ribavirin, which tends to accumulate in red blood cells, thus leading to hemolysis (often dose-limiting). Gish and colleagues[17] presented results of a phase 2 trial of viramidine and ribavirin used in combination with peginterferon alfa-2a to assess the effect of treatment on hemoglobin levels and antiviral activity.
471014 tn?1207435481 The destruction of red blood cells which leads to the release of hemoglobin from within the red blood cells into the blood plasma. Decreased to absent levels occur more with intravascular than extravascular hemolysis: haptoglobin binds hemoglobin, and carries it to the reticuloendothelial system. Thus, haptoglobin is useful in work-up for hemolytic states. It is low in the megaloblastic anemias, which have a hemolytic component. It is decreased in infectious mononucleosis.
264121 tn?1313033056 The current dosage recommendations for ribavirin are based on body weight (bw). Ribavirin is mainly eliminated by the kidneys and we have recently shown that ribavirin plasma concentrations are determined primarily by renal function. It is therefore reasonable to hypothesize that side-effects of ribavirin, i.e. anaemia, should be more closely related to plasma concentrations of ribavirin than to the dose per kg bw.
Avatar m tn The depletion in red cells can be managed either by taking a hormone supplement (procrit/epoetin) or by reducing the ribavirin dose.If your viral load is undetectable this can be safely done. Similarly the white cells can be artificially boosted,or the dose of interferon reduced.Reducing or skipping interferon is not desirable. Iron tablets are not really the issue here.
1853014 tn?1340042175 HCV FibroSURE is not recommended in patients with Gilbert Disease, acute hemolysis (e.g. HCV ribavirin therapy mediated hemolysis), acute hepatitis of the liver, extra-hepatic cholestasis, transplant patients, and/or renal insufficiency patients. Any of these clinical situations may lead to inaccurate quantitative predictions of fibrosis and necroinflammatory activity in the liver. Comment: The performance characteristics of this test have been determined by LabCorp.
264121 tn?1313033056 Sounds like you're on weight based ribavirin, which is good. 1000mg should be sufficient for someone of your weight. And yes technically you should take the riba twice a day, and yes usually the pills are 200mg (mine were at least), so you'll need five a day. However, don't get too hung up on when you take the riba, it has a very long half-life so it's not like it'll drop to unefficacious levels in the afternoon if you happen to forget to take it one morning.
Avatar f tn I think hemodialysis and its suppression of immune function is making the HCV disease progress. Ribavirin leads to severe hemolysis in people with a creatinine clearance of less than 20; mine is about 7. Although there have been no proper scientific trials yet because they are scared to enroll people in the riba arm; thinking it might be a bit unethical to risk their lives in the name of scientific inquiry. Also I am on transplant list and there is a real worry that 1.
180992 tn?1383377657 however, lower doses also may reduce treatment efficacy. Elevations of bilirubin usually are an indication of hemolysis caused by the ribavirin and usually are concomitant with drops in the hematocrit. Between 1 and 2 percent of patients will develop thyroid abnormalities severe enough to require clinical interventions, so thyroid-stimulating hormone levels should be checked periodically while the patient is on treatment. Triglycerides can be elevated and can cause pancreatitis.
29837 tn?1414538248 It is known that the triphosphate metabolite of ribavirin accumulates in red blood cells and causes oxidative injury to red blood cell membranes, thereby resulting in hemolysis. Patients who develop an anemia on ribavirin therapy have a responsive reticulocytosis. However, DeFrancesci et al.
3203287 tn?1346460234 With use of higher doses of ribavirin (1000-1200 mg/d), hemoglobin levels frequently decline by 2-3 g/dL, as seen in this case. In addition to causing hemolysis, ribavirin can also down-regulate the number of erythropoietin receptors.
Avatar n tn There are studies that show that higher ribavirin dosages are associated with better odds of sSVR. You said you were UND at week 12, but I'm guessing you weren't a rapid responder or UND at week 4? I just don't see a problem with doing this. I am having to decrease from 1000mg by 200mg to 400mg per day (I'm trading off 800mg one day, 600mg the next) due to hemaglobing counts that keep going down between 7-8. I have a lot going for me.
Avatar f tn Fall of 2011 I was on Interferon and Ribavirin, never did get to the Victrelis (13 weeks). Dr. took me off everything because I got very skinny and anemic. Started back on Interferon and Ribavirin. They are adding Victrelis for my hep c triple treatment very soon. Happy but scared. My Dr. took me off Cymbltia 60mgs about 1 month ago, after being on it for about 2 1/2 years. He said it would be better for my liver. Did it cold turkey, (not too bad).