Ribavirin clearance

Common Questions and Answers about Ribavirin clearance

rebetol

Avatar f tn 3 Pharmacokinetics The terminal half-life of ribavirin following administration of a single oral dose of ribavirin is about 120 to 170 hours. The total apparent clearance following administration of a single oral dose of ribavirin is about 26 L/h. There is extensive accumulation of ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://kadmon.com/files/ribasphere-tablets-pi.
Avatar f tn Am I the only one on here taking 1,200 mgs of ribavirin, who is going thru Triple Tx? I keep noticing people mentioning lower dosages. I have heard of smaller people taking less, and I am 5'9'', 160 pounds, but I think my Doctor is prescribing this same amount for most of the people in my home group, that I've talked to.
Avatar m tn I have been on Ribavirin and Pegasys since 4-3-09. This past week I was diagnosed with Anemia and given a Procrit shot, which helped. Does anybody have suggestions as to prevent this from happening again during my treatment?
Avatar f tn Male patients and their female partners must practice effective contraception (two reliable forms) during treatment with ribavirin and for the 6 months post-therapy period (e.g., 15 half-lives for ribavirin clearance from the body). A Ribavirin Pregnancy Registry has been established to monitor maternal-fetal outcomes of pregnancies in female patients and female partners of male patients exposed to ribavirin during treatment and for 6 months following cessation of treatment.
3093770 tn?1389742726 The total apparent clearance following administration of a single oral dose of Ribavirin is about 26 L/h. There is extensive accumulation of Ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://www.drugs.com/pro/ribavirin.
Avatar m tn perhaps it will be useful eric Helper T cell cytokine response to ribavirin priming before combined treatment with interferon alpha and ribavirin for patients with chronic hepatitis C Norihiro Furusyoa, b, , , Norihiko Kubob, Kazuhiro Toyodab, Hiroaki Takeokab, Shigeki Nabeshimaa, Masayuki Murataa, Makoto Nakamutac and Jun Hayashia, b aDepartment of General Medicine, Kyushu University Hospital, Higashi-Ku, Fukuoka 812-8582, Japan bDepartment of Environmental Medicine and Infectious Diseases,
Avatar n tn showed no difference in the SVR rate in patients with genotypes 2 and 3 infections using ribavirin doses ranging from 800 to 1,200 mg daily. Thus, the issue can be narrowed to optimizing therapy for genotype 1 patients." Speaking as a SVR-hungry Geno 1, I wonder if it would be the height of idiocy to increase my daily ribavirin dosage from 1000 mg to 1200 mg? I've been taking the lower amount, according to the current weight-based regime.
Avatar m tn I also recently learned I have relapsed after completing the 12 week treatment with Solvadi and Ribavirin. I have Hep-C, genotype 2. The virus went undetectable after 4 weeks and remained that way 6 weeks after completing treatment, then showed up in a blood test done at the 12 week marker after treatment. Needless to say I was heartbroken. I was diagnosed in 1993 and have significant cirrhosis. I will keep hoping for a new drug protocol that will knock it out once and for all.
233616 tn?1312790796 In comparison with corresponding plasma values of ribavirin following a high-purine meal, Cmax, AUC0-144 and AUC0-∞ of ribavirin following a low-purine meal were 136% (90% confidence internal [CI]: 120%-155%), 134% (90% CI: 118%-153%), and 139% (90% CI: 120%-159%), respectively. This study indicates that dietary purines have an effect on ribavirin absorption. Dosage regimens of ribavirin might need to be adjusted according to the purine content of the meal.
Avatar m tn Replicative homeostasis also suggests a primarily non-immunological mechanism that mediates increased immune responsiveness during treatment with ribavirin (and other nucleos(t)ide analogues), explicating the enhanced second-phase clearance of HCV ribavirin promotes and, thus, the apparent immunomodulatory action of ribavirin. More importantly, RH suggests specific new antiviral therapeutic strategies...
Avatar m tn It remains unclear whether the spontaneous clearance of hepatitis C virus (HCV) RNA from the serum of HCV-infected patients is associated with complete elimination of the HCV virus from hepatic tissue or low levels of viral replication can persist in some patients but are controlled by specific cellular and humoral immune responses.
Avatar m tn Thank you to so many on this forum for their knowledge and advice, specifically in regards to the potential benefits of increasing Ribavirin dosage for hard to treat patients. I am a geno 3A previous nonresponder (less than a 1 log drop after six months of treatment in 2001 with PegIntron and 800 mg. weight based Ribavirin). I recently retreated: Baseline VL 118,779 (Pegasys and 800 mg. Ribavirin) 4 week VL 95,359 (dismal results so I increased Riba at 5 1/2 weeks to 1000 mg.
Avatar f tn Has anyone found any new info on the “high fat food taken with ribavirin” issue? All I keep finding are supposed "sources" that usually lead back to the same study, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1804105/ and they are repeating or "gleaning" the same inconclusive data from this one study. Maybe someone knows of a newer study with a professional abstract that was approved for publication?
Avatar m tn You bring up an interesting point and perhaps it doesn't get stated here as often as it should. Treatment for geno 1 hep c is 48 weeks of peginterferon and ribavirin, period. This is the only approved "standard of care" (SOC) treatment. This is what most insurance co.'s will cover. Any treatment outside of that protocol is considered "experimental" and that is why some insurance co.'s will not pay for any extended treatment past 48 weeks.
151263 tn?1243377877 Schering-Plough also is conducting a large Phase II study evaluating the safety and efficacy of boceprevir 800 mg TID in combination with PEGINTRON and REBETOL in patients chronically infected with HCV genotype 1 who were nonresponders to previous peginterferon and ribavirin combination therapy. The study involves approximately 350 patients at centers in the United States and Europe. All study participants have completed treatment and are in the follow-up phase.
Avatar f tn html#i4i_section_id_923103dc-10fb-4562-8cc1-fe0c59767db3 How should I take Ribavirin tablets? Take Ribavirin tablets exactly as your healthcare provider tells you. Your healthcare provider will tell you how many Ribavirin tablets to take and when to take it. Take Ribavirin tablets with food. If you miss a dose of Ribavirin tablets, take the missed dose as soon as possible during the same day. You should skip a dose if more than 6 hours have passed since it was due to be taken.
Avatar f tn 5 VL Copies apx BMI Body Mass Index WHR Waist to Hip Ratio Drug Acronyms IFN Interferon (Alpha 2a / Alpha 2b) NPIA Non-Pegylated Interferon Alpha PegIFN Pegylated Interferon (Alpha 2a / Alpha 2b) CIFN Consensus Interferon (Infergen/alphacon) RBV Ribavirin RVN Ribavirin Riba Ribavirin WBR Weight Based Ribavirin WBD Weight Based Dose FDR Fixed Dose Ribavirin LDR Low Dose Ribavirin (Same as FDR) EPO Erythropoietin Epoetin alfa (Epogen/Procrit), Darbepoetin alfa (Aranesp) Neup Neupo
Avatar m tn 16 Ribavirin The synthetic purine nucleoside Ribavirin rapidly enters eukaryotic cells and after intracellular phosphorylation exhibits virustatic activity against a broad spectrum of DNA and RNA viruses.25 Several studies have been conducted to evaluate ribavirin monotherapy in daily doses of 600-1,200 mg in the treatment of chronic hepatitis C.26-28 While all trials consistently showed a decrease in aminotransferase levels, no virologic end-of-treatment responses were observed.
Avatar m tn We aimed to evaluate the effect of pegylated interferon/ribavirin (PIFN/R) and HCV clearance on cerebral metabolism and neuropsychological performance. METHODS: Fifteen non-cirrhotic HCV positive subjects underwent (1)H MR spectroscopy (MRS) before, during, and after treatment with PIFN/R.
1893294 tn?1321220750 ABT-267 4. ABT-333 with or without Ribavirin. He said it is phase III trial and SVR12 rates were more than 90% . All meds are oral and no grand side effects... but doc couldn't show me phase II results and i could not find any information on internet. Anyone knows this trial? (31 yrs old, white male, naive, 1.000.
Avatar m tn A new article on HCV - it is involved and you must register to view. It's free though and worth it if you want to learn about HCV treatment. <A HREF="http://clinicaloptions.com/Hepatitis/Annual%20Updates/2006%20Annual%20Update/Modules/Chung/Pages/Page%201.
Avatar f tn D reports that 61-80% of Hep C Genotype 1 participants who were previous treatment failures or null responders with Cirrhosis achieved SVR with TMC435 combined with Interferon and Ribavirin.
Avatar m tn //hepatitis-c.emedtv.com/hepatitis-c/hepatitis-c-diet.
Avatar m tn Study 2 In a related study, Cristina Tural and colleagues analyzed the association between ribavirin plasma trough concentrations and HCV RNA clearance in the Spanish CORAL-2 study. The study included 65 interferon-naive HIV-HCV coinfected patients. About 72% were men, the mean age was 41 years, and about 80% had HCV genotype 1. They had well-controlled HIV disease, with a mean CD4 count of roughly 600 cells/mm3 and 75% with undetectable HIV viral load.
Avatar f tn Reducing the peginterferon dose during the first 20 weeks of treatment reduced viral clearance and SVR. In contrast, reducing ribavirin did not affect either W20 VR or SVR as long as patients remained on full-dose peginterferon. Discontinuing ribavirin prematurely was associated with a marked decline in both VR and SVR.
238010 tn?1420409872 5 VL Copies apx BMI Body Mass Index WHR Waist to Hip Ratio Drug Acronyms IFN Interferon (Alpha 2a / Alpha 2b) NPIA Non-Pegylated Interferon Alpha PegIFN Pegylated Interferon (Alpha 2a / Alpha 2b) CIFN Consensus Interferon (Infergen/alphacon) RBV Ribavirin RVN Ribavirin Riba Ribavirin WBR Weight Based Ribavirin WBD Weight Based Dose FDR Fixed Dose Ribavirin LDR Low Dose Ribavirin (Same as FDR) EPO Erythropoietin Epoetin alfa (Epogen/Procrit), Darbepoetin alfa (Aranesp) Neup Neupo
577132 tn?1314270126 The study examined 103 participants who received pegylated interferon-alpha-2b plus ribavirin (PEG IFN/ribavirin). All participants were psychiatrically evaluated prior to initiation of the medication and at 4, 8, 12 and 24 weeks of PEG IFN/ribavirin treatment. Only 34% of the patients who had a significant increase in depression cleared the hepatitis C virus from their blood at 24 weeks, as compared to 59%-69% of patients with milder increases in depression.
Avatar f tn A prospective multicenter study to investigate the efficacy of pegylated interferon-alpha2b and ribavirin in patients with HBV/HCV co-infection. Potthoff A, Wedemeyer H, Boecher WO, Berg T, Zeuzem S, Arnold J, Spengler U, Gruengreiff K, Kaeser T, Schuchmann M, Bergk A, Forestier N, Deterding K, Manns MP, Trautwein C; for the Hep-Net B/C Co-infection Study Group. Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Carl-Neuberg-Str.
5536514 tn?1373503602 Only your hepatologist at a liver clinic or transplant center who knows your complete health status can determine if it is safe to do HCV treatment or not. There are too many individual factors that we don't know about to offer an educated opinion. Beside we are not experienced with kidney disease which is obviously a serious matter as kidneys commonly fail when liver failure occurs. You say you have advanced cirrhosis? What do you mean?