Ribavirin administration

Common Questions and Answers about Ribavirin administration

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Avatar f tn 3 Pharmacokinetics The terminal half-life of ribavirin following administration of a single oral dose of ribavirin is about 120 to 170 hours. The total apparent clearance following administration of a single oral dose of ribavirin is about 26 L/h. There is extensive accumulation of ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://kadmon.com/files/ribasphere-tablets-pi.
Avatar f tn Am I the only one on here taking 1,200 mgs of ribavirin, who is going thru Triple Tx? I keep noticing people mentioning lower dosages. I have heard of smaller people taking less, and I am 5'9'', 160 pounds, but I think my Doctor is prescribing this same amount for most of the people in my home group, that I've talked to.
3093770 tn?1389742726 The terminal half-life of Ribavirin following administration of a single oral dose of Ribavirin is about 120 to 170 hours. The total apparent clearance following administration of a single oral dose of Ribavirin is about 26 L/h. There is extensive accumulation of Ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://www.drugs.com/pro/ribavirin.
Avatar m tn This is one of the sources I found: http://www.drugs.com/pro/ribavirin.html "Effect of Food on Absorption of Ribavirin" "Bioavailability of a single oral dose of Ribavirin was increased by co-administration with a high-fat meal. The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin tablets were taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.
Avatar m tn gov/pmc/articles/PMC1804105/ Effect of Food on Absorption of Ribavirin Bioavailability of a single oral dose of Ribavirin was increased by co-administration with a high-fat meal. The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin tablets were taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)]. http://www.drugs.com/pro/ribavirin.
Avatar m tn FULL PRESCRIBING INFORMATION 1 INDICATIONS AND USAGE Monotherapy of SOVALDI is not recommended for treatment of CHC. 2 DOSAGE AND ADMINISTRATION SOVALDI should be used in combination with ribavirin or in combination with pegylated interferon and ribavirin for the treatment of CHC in adults.
2030686 tn?1351692148 Keep this medication in the container it came in, tightly closed, and out of reach of children. Store ribavirin tablets and capsules at room temperature and away from excess heat and moisture (not in the bathroom). Store ribavirin oral solution in the refrigerator or at room temperature. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
135456 tn?1301441224 Does anyone feel the Ribavirin really hit them a few hours after they take it? I wake up feeling decent but as soon as I take my first dose I'm feeling lower than a snakes nuts. I feel my liver swell and my extremities get ice cold. I'm conviced the interferon is a cakewalk by itself but the Ribavirin is the evil component to treatment. Any thoughts?
Avatar m tn perhaps it will be useful eric Helper T cell cytokine response to ribavirin priming before combined treatment with interferon alpha and ribavirin for patients with chronic hepatitis C Norihiro Furusyoa, b, , , Norihiko Kubob, Kazuhiro Toyodab, Hiroaki Takeokab, Shigeki Nabeshimaa, Masayuki Murataa, Makoto Nakamutac and Jun Hayashia, b aDepartment of General Medicine, Kyushu University Hospital, Higashi-Ku, Fukuoka 812-8582, Japan bDepartment of Environmental Medicine and Infectious Diseases,
135456 tn?1301441224 Have you had previous experience with 1600 mg/day of ribavirin? If not, you might start sooner and titer up more gradually to make sure that you can handle the dose. Keep in mind that it can take 1-3 weeks for a change in ribavirin dose to be reflected in your hemoglobin. Also, and again based on your previous treatment experience, consider Procrit (epo) coincidental with the riba pre-dosing for same reasons.
446474 tn?1446351282 No ] To determine if the administration of a combination of GS 7977 and ribavirin to HCV-infected subjects with hepatocellular carcinoma (HCC) meeting the MILAN criteria prior to undergoing liver transplantation for up to 24 weeks can prevent post-transplant re-infection as determined by a sustained post-transplant virological response (HCV RNA <LLoQ) at 12 weeks post-transplant.
233616 tn?1312790796 An empirical estimate of the ribavirin half-life in this study-based on the last 3 time points, including the predose value for period 2-yielded half-lives ranging between 209 and 550 hours. Administration of ribavirin after a low-purine meal caused an increase in exposure of ribavirin compared to a high-purine meal.
Avatar f tn Effect of Food on Absorption of Ribavirin Bioavailability of a single oral dose of ribavirin was increased by co-administration with a high-fat meal. The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when COPEGUS was taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)]. " http://www.accessdata.fda.
Avatar m tn The Effect of the Addition of Ribavirin with Harvoni treatment.. With the addition of Ribavirin, Harvoni treatment time can be reduced to 12 weeks with similar to the SVR rates for 24 weeks of Harvoni used without Ribavirin! That is 12 weeks less time dealing side effects if a person can tolerate 12 weeks of Ribavirin. Plus a reduced cost of treatment. ------------------------------------------------------------------------------------ For those with HIVHCV -COINFECTION http://www.
Avatar f tn Ribavirin, an antiviral drug with in vitro activity against both DNA and RNA viruses, is approved in the United States for the treatment of hepatitis C and respiratory syncytial virus. A loading dose and short-term administration of oral ribavirin significantly improved symptoms and signs of influenza type A or B infection in 25 patients. The antiviral effect was not significant. No adverse clinical effects or significant laboratory values were observed.
Avatar m tn I have Hep-C G2. Started SOVALDI and Ribavirin 12 week treatment Dec 23, 2013 (viral load at 2.5 million), within 4 weeks into treatment my Hep C virus was undetectable. 12 weeks end of treatment my Hep C virus was undetectable. 4 weeks after treatment my Hep C virus was undetected. 12 weeks after of treatment my Hep C virus was detected at 83,000 viral load. It relapsed. What are my chances of a cure now?
Avatar f tn 75 kg). The terminal half-life of Ribavirin following administration of a single oral dose of Ribavirin is about 120 to 170 hours. The total apparent clearance following administration of a single oral dose of Ribavirin is about 26 L/h. There is extensive accumulation of Ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose.
Avatar m tn Although a standard meal did not affect ribavirin bioavailability (F1), administration of ribavirin with a high-fat meal increased bioavailability by 46% relative to the fasting state. A high-fat meal prolonged the duration of the zero-order input part of the absorption model, with D1 increasing from 0.498 h (fasting and standard meal) to 0.740 h. The type of meal also influenced the first-order input part of the absorption model (Table 1).
Avatar m tn A couple days and a dozen calls later I found out that a generic ribavirin named Ribasphere from Par/3Rivers was approved for distribution and delivery starting on 12/5/05. This event, along with the nature of my pharmacy coverage which caps costs of brand name drugs when there is NO generic, led to some anxious moments. The pharmacy ran the new generic and the old, lower co-pay appeared. After clearing the change with my doc, the order went through.
Avatar m tn 18 *Pegylated interferon-α The elimination half-life for unmodified interferon-α ranges from 4 to 10 hours, with peak serum concentrations occurring at 3 to 8 hours following subcutaneous administration. Thus, current antiviral treatment regimens require frequent administration of standard interferon-α with intervals ranging from three to seven times per week for periods of 24 to 48 weeks.
Avatar m tn Interferon, Interferon + Ribavirin, and Interferon+Ribavirin+Tepavier. I also have compensated cirrhosis. I've had HEPC for over 50 years. Currently I'm on week 4 of Havoni + Ribavirin (1200 mg a day + 1 Harvoni). I read that the recommended duration for we hard-to-treat previous non-responders is 24 weeks, but my clinician is insisting 12 weeks will be good enough and there is no difference in the outcomes for 12 weeks vs 24 weeks. Is this correct data?
Avatar f tn this month, results of the ELECTRON Study demonstrated a 100% rate of SVR12 in G1 patients who were previous non-responders with fibrosis and Cirrhosis. Link is at the bottom.
4950316 tn?1394188185 The bioavailability of ribavirin 600 mg was decreased by co-administration with an antacid containing magnesium, aluminium and methicone; AUCtf decreased 14%. It is possible that the decreased bioavailability in this study was due to delayed transit of ribavirin or modified pH. This interaction is not considered to be clinically relevant. http://www.drugs.com/uk/copegus-200mg-and-400mg-film-coated-tablets-spc-5377.
Avatar n tn the Ribavirin Pregnancy Registry. Roberts SS. Ribavirin Pregnancy Registry Coordinating Center at Kendle International, Inc., Wilmington, NC, USA. ***@**** Ribavirin, used in combination with an interferon, is used for the treatment of chronic hepatitis C. Ribavirin is a Federal Drug Administration Pregnancy Category X product, indicating that its use is contraindicated in women who are pregnant.
Avatar m tn Because of this most insurance companies will only pay to Procrit to combat anemia caused by ribavirin. Most insurance companies cover epoetin alfa (Epogen®, Procrit®) as medically necessary for the treatment of anemia in the presence of adequate iron stores (i.e. normal transferrin or serum ferritin level) for ...
1118724 tn?1357014191 COPEGUS (ribavirin) is available as a light pink to pink colored, flat, oval-shaped, film-coated tablet for oral administration. Each tablet contains 200 mg of ribavirin and the following inactive ingredients: pregelatinized starch, microcrystalline cellulose, sodium starch glycolate, cornstarch, and magnesium stearate.
Avatar f tn I think your schedule would be better if it was: 7 Incivek, Riba 3 Incivek, Riba 11 Incivek It is best to take the Incivek every 8 hours. As far as food with Riba, yes, they did studies. "Effect of Food on Absorption of Ribavirin" "Bioavailability of a single oral dose of Ribavirin was increased by coadministration with a high-fat meal.
4333925 tn?1359106042 Ribavirin - Clinical Pharmacology The terminal half-life of Ribavirin following administration of a single oral dose of Ribavirin is about 120 to 170 hours. The total apparent clearance following administration of a single oral dose of Ribavirin is about 26 L/h. There is extensive accumulation of Ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://www.drugs.com/pro/ribavirin.
2024274 tn?1332960026 The answer to your question is NO, you cannot open the Ribavirin, incivek, or victrelis. Ribavirin Capsules Dosage and Administration Under no circumstances should Ribavirin Capsules be opened, crushed, or broken. Ribavirin Capsules should be taken with food [see Clinical Pharmacology (12.3)]. Ribavirin Capsules should not be used in patients with creatinine clearance <50 mL/min. http://www.drugs.com/pro/ribavirin-capsules.