Prometrium is given to treat luteal phase
defect, but there really is no evidence that we are able to diagnose
luteal phase defect, or that
luteal phase defect causes recurrent pregnancy loss. Luteal phase defect as a cause of recurrent miscarriages is something that we have talked about for decades, but without any good proof. In a normal menstrual cycle, your own ovaries do not start to produce progesterone until after you ovulate.