Peginterferon and ribavirin side effects

Common Questions and Answers about Peginterferon and ribavirin side effects

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Avatar m tn Side effects from sofosbuvir and ribavirin treatment are listed in the top line results of the clinical trials. "In FISSION (Genotype 2/3 treatment-naïve), just 1% of patients receiving 12 weeks of sofosbuvir plus ribavirin discontinued therapy. However, a higher rate — 11% — of patients who received 24 weeks of peginterferon plus ribavirin stopped treatment.
Avatar f tn I'm on my 4th day of Peginterferon + Ribavirin. I'm having the depression side effect and my brain keeps going on pause mode with out notice . I read the side effects for Lexapro. Sounds to me like the Lexapro will enhance the side effects of the HCV treatment and maybe out weigh the benifits ? How bad dose the depression have to be before I take a chance on the possible benifits of lowering my depression . Will the Lexapro help with the Brain pause side effects as well?
Avatar m tn I am in week 35 of the 48 week treatment of Peginterferon alpha 1a and Ribavirin. I have not experienced flu like symptoms at all but the other side effects have more than made up for the one that got away...
Avatar n tn I'm happy to say that except for a little fatigue and insomnia I've had zero side effects. I have put this off for 5 years because I was so leary of the sides, now I feel silly for waiting. I almost feel guilty because so many people are having such a hard time. I know I am early on in TX and maybe things will change but I'll stay optimistic. Any way I just thought I'd tell someone that might be holding off because they are scarred that it isn't always bad.
Avatar f tn I too am on Victrelis and like Bovary said, it seems the side effects vary. I am in my 14th week and the side effects have been tolerable. I am also on the younger side (not as young as you) and I am 36 years old and besides the Hep C was in great health prior to treatment. My SX have been feeling like I have a permanant hangover, I can get through the day but I always have that "icky" feeling that never goes away. My first 4 weeks lead in without the Victrelis was tolerable.
Avatar m tn Hello everyone! Just came from a doctor's appointment today & I just learned that my grandmother (68yrs old) has genotype 1A. She's recently diagnosed with Cirrhosis stage 3. Today, her gastro doctor advised she take a risk & try the treatment in order to "freeze" the distruction of her liver which may or may not work.
Avatar m tn The last test show AST 124, ALT 212, I will be starting treatment prescribed: Ribapack ribavirin tablet 400 mg & Ribavirin tablet 600mg dose pack # 56 tablets per month, and peginterferon alfa-2b inj kit 120 Mcg/0.5ml.
Avatar m tn Ten patients with chronic hepatitis C, genotype 1 and high viral load were treated with peginterferon alfa-2a and ribavirin for 48 weeks in a prospective trial. The initial ribavirin dose was individualized and calculated from a pharmacokinetic formula based mainly on renal function. Ribavirin plasma concentrations were monitored, and the dose was adjusted to reach the target concentration.
Avatar n tn I am on week 21 of my ribavirin and peginterferon treatment. I am probably experiencing every side effect this medicine can deliver. Have had 2 transfusions within 4 weeks of each other and the second one only increased my cell count from 7.5 to 7.7. I was given Procrit and was told that I may have to have this injection every week. I am also experiencing sores and problems in my mouth. The doctor says that this is also a side effect to the medicine.
Avatar f tn This was shown in a retrospective analysis of a large, randomized, placebo-controlled trial in which patients who achieved RVR had an SVR rate of approximately 90% regardless of whether they received peginterferon alfa and ribavirin, standard interferon and ribavirin, or peginterferon alfa monotherapy. In addition, the likelihood of SVR patients with genotype 1 infection who achieve an RVR does not appear to be affected by shortening the duration or reducing the dose of ribavirin.
Avatar f tn -----------------------DOSAGE AND ADMINISTRATION ----------------------- • 800 mg administered orally three times daily (every 7 to 9 hours) with food (a meal or light snack). (2) • VICTRELIS must be administered in combination with peginterferon alfa and ribavirin. (2) • Refer to peginterferon alfa and ribavirin Package Inserts for specific dosing instructions. (2) http://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.
Avatar n tn Probaly half the people here who are treating with interferon and ribavirin for HepC are using alpha2A. The other peginterferon is alpha2B. 2a is called Pegasys. You can go to www.pegasys.com for all the manufacturer information. 2a and 2b seem to have similar statistical results for HepC. Either is used in standard of care, for at least Hepc (which is my perspective of experience) I'm not so sure sure about HepB though.
Avatar f tn I read all the info and read up on expected side effects but this is truly an experience I will not forget... Been optimistic, My ALT levels are back down to normal and it is looking good, ****** treatment, ****** treatment.
26471 tn?1211940121 These patients are sensitive to the antiviral and immunologic effects of interferon and ribavirin, and two previous studies have suggested that most nonresponders who responded to higher doses of interferon or peginterferon during retreatment are those with a previous partial virologic response Effect of ribavirin dosing on virologic response The starting dose of ribavirin may also play a role in enhancing virologic response.
Avatar n tn My Pegasys and Ribavirin are approx $2,500 a month. I pay a co-pay of $5.00 for the riba and $10 for the Peg each month.
Avatar m tn I just started Sovaldi + Ribavirin + Peginterferon for Genotype 1a a week ago. The side effects from my first injection were a doozy. I felt it working in about 10 minutes and I had a cloudy flu like feeling within an hour. I went to bed and in the middle of the night I had muscle pains, hot and cold flashes, cramping, and the most diesel headache I have ever had. It occurred to me that I may have hit a vein even though I grabbed the skin on my stomach and pinched a good bit of it.
Avatar n tn Hi to everybody! I was trying to find any studyies about lowering the ribavirin dosage and outcome of tx.. anyone has done some googleing about it??? Got great neews! got finaly my week 2 test; form 7.7 million units, to 1.1 million units!! ..when u can consider your self an early responder?? ..i know, i'm such a winer.. i'm on my 6/48 week, and allready wining..
233616 tn?1312790796 Asian patients with HCV showed a significantly greater SVR on interferon and ribavirin treatment compared to white patients. The effects of food and food composition on ribavirin have not been adequately considered despite evidence showing greater bioavailability during the fed state. This may be related to better dissolution of ribavirin. Our data provide additional evidence that the purine content of food can alter the bioavailability of ribavirin.
3093770 tn?1389742726 At the same time I have been told that some people had tx side effects but not many (Really?) and I did not get any preventive anti nausea or itch cream. Hmmmm! We are only a phone call away and if gets really bad there is always emergency services.
Avatar f tn 001) and the mean doses of ribavirin (P /=12 mg/kg/day of ribavirin and ribavirin exposure affected the relapse even after treatment week 12, while Peg-IFN could be reduced to 0.6 mug/kg/week after week 12 without the increase of relapse rate. Ribavirin showed dose-dependent correlation with the relapse.
Avatar m tn While HCV in children is typically mild, some cases do progress to cirrhosis and liver cancer. Treatment of HCV with peginterferon and ribavirin is approved for young children and offers the most benefit while liver disease is mild. However, there are concerns about the potential side effects of peginterferon therapy in children, which is the focus of our current study.
Avatar f tn Everybody is different, so it's hard to tell you that you will have certain side effects, when you might be one of the people who doesn't have that side effects. But, here are some common ones that are experienced by many using Interferon and Riba (I didn't find Sovaldi to have any additional side effects than I normally would with the Peg/Riba). 1. Extra tiredness/fatigue. This is a normal side effect and many people will find that they have to pace themselves and rest alot more.
577132 tn?1314270126 Included were 201 patients with chronic hepatitis C and advanced fibrosis who previously didn't response to treatment. The patients were treated with peginterferon alfa-2a and ribavirin for 24 weeks. The 74 patients who had undetectable hepatitis C virus (HCV) RNA at week 20 continued at the same doses to complete 48 weeks of antiviral treatment.
577132 tn?1314270126 Peginterferon and Ribavirin Dosing and the Utility of Growth Factors Clin Liver Dis 12 (2008) 487–505 Mitchell L. Shiffman, MD Impact of adverse events and dose reduction As opposed to interrupting or prematurely stopping ribavirin, which enhances breakthrough and relapse, recent data suggest that merely reducing the dose of ribavirin in response to adverse events does not significantly affect these milestones, and therefore has little impact on the SVR.
Avatar m tn gov/ct2/show/study/NCT02128542 I have posted a lot of information of my pre treatments history, labs, biopsies or existing conditions in my first journal and my treatment labs and side effects in my other journal. Click my name and look in the lower left side of the page for my journals if interested (I probably provided much more detail than needed) I really hope we don't get many failing the new treatments.
Avatar f tn Ribavirin exposure after multiple dosing when taken with food was comparable in patients receiving peginterferon alfa-2a and Copegus and interferon alfa-2b and ribavirin. In order to achieve optimal ribavirin plasma concentrations, it is recommended to take ribavirin with food." http://www.medicines.
135456 tn?1301441224 Risks to pregnancies Mental health problems (such as irritability, depression, anxiety, aggressiveness, trouble with drug addiction or overdose, thoughts about suicide, suicide attempts, suicide and thoughts about homicide) Blood problems (like a drop in blood cells leading to increased risk for infections, bleeding and/or heart or circulatory problems) Infections (which sometimes cause death) Lung problems (like trouble breathing, pneumonia) Eye problems (like blurred vision, loss of vis
Avatar f tn Based on data with other genotypes and preliminary results in a small group of genotype 3-infected patients, the triple combination of pegylated IFN-α, ribavirin, and sofosbuvir (Option 1) appears to be more efficacious with a shorter duration than the combination of sofosbuvir and ribavirin (Option 2), which is suboptimal in patients with cirrhosis and who have previously failed IFN and ribavirin.