Ribavirin adverse effects

Common Questions and Answers about Ribavirin adverse effects


Avatar m tn Side effects from sofosbuvir and ribavirin treatment are listed in the top line results of the clinical trials. "In FISSION (Genotype 2/3 treatment-naïve), just 1% of patients receiving 12 weeks of sofosbuvir plus ribavirin discontinued therapy. However, a higher rate — 11% — of patients who received 24 weeks of peginterferon plus ribavirin stopped treatment.
446474 tn?1446351282 Although every patient will experience adverse effects to differing degrees, a systematic approach to their management can be very helpful. * Peginterferon/Ribavirin Table 17. Summary of Adverse Effects of Peginterferon/Ribavirin * Protease Inhibitors: Boceprevir and Telaprevir As both approved protease inhibitors (PIs) are used in combination with peginterferon and ribavirin, the adverse effects summarized in Table 17 apply to PI recipients.
Avatar f tn In a multivariate analysis, ribavirin dose reduction vs EPO was not a significant predictor of treatment success. Serious adverse events occurred with similar frequency in both arms, 16% with ribavirin dose reduction and 13% with EPO. Discontinuation rates due to any adverse event were also similar, 11% and 13% respectively. 2.0% and 2.4%, respectively, stopped treatment due to anemia.
Avatar f tn pdf ------------------------------ADVERSE REACTIONS------------------------------ In subjects receiving VIEKIRA PAK with ribavirin, the most commonly reported adverse reactions (greater than 10% of subjects) were fatigue, nausea, pruritus, other skin reactions, insomnia and asthenia. In subjects receiving VIEKIRA PAK without ribavirin, the most commonly reported adverse reactions (greater than or equal to 5% of subjects) were nausea, pruritus and insomnia. (6.
Avatar m tn I am 5 weeks into Sovaldi/Ribavirin treatment and all is going very well. I have been undetected since week two and I feel fine. I am cross country skiing in the Vermont mountains 3-4 times a week and feel good, maybe a little off but then I have been skiing quite a bit lately. I was out yesterday with a bunch of guys 10-20 years younger than me and I was the one waiting at the top of the climbs. The nurse practitioner at the hepatology department said I should exercise all I want.
Avatar n tn I'm on week 32 of triple with Victrellis. This weekend I took my ribavirin 600mg twice in a 30 minute period. I admit this is not the first time I have done this. But this time I feel like I have a lead over coat on and every joint in body hurts, stomach cramps..just feel like awful. I skipped my next dose and have reduced 2 subsequent doses to 400 mg each. Any comments?
26471 tn?1211940121 These patients are sensitive to the antiviral and immunologic effects of interferon and ribavirin, and two previous studies have suggested that most nonresponders who responded to higher doses of interferon or peginterferon during retreatment are those with a previous partial virologic response Effect of ribavirin dosing on virologic response The starting dose of ribavirin may also play a role in enhancing virologic response.
Avatar m tn perhaps it will be useful eric Helper T cell cytokine response to ribavirin priming before combined treatment with interferon alpha and ribavirin for patients with chronic hepatitis C Norihiro Furusyoa, b, , , Norihiko Kubob, Kazuhiro Toyodab, Hiroaki Takeokab, Shigeki Nabeshimaa, Masayuki Murataa, Makoto Nakamutac and Jun Hayashia, b aDepartment of General Medicine, Kyushu University Hospital, Higashi-Ku, Fukuoka 812-8582, Japan bDepartment of Environmental Medicine and Infectious Diseases,
446474 tn?1446351282 We have seen a lot of courageous people in this forum over the years fight week after week with the side effects and adverse events to complete the duration of their treatment. I think we have so many folks here who are examples for the new comers who see others do something and then begin to believe that they too can do it. People are able to over come their fears when they see others going though treatment week after week.
233616 tn?1312790796 The purpose of this study is to assess the effects of purine content in the meal on oral single-dose pharmacokinetics of ribavirin in healthy participants. Participants Healthy male participants between ages 21 and 50 years (inclusive) were considered eligible for this study. This study was conducted in the Clinical Trials and Research Unit, Changi General Hospital (CGH), Singapore, in accordance with the protocol that was approved by the Institutional Review Board, CGH, Singapore.
Avatar n tn I don't think we're taking the adverse side effects of tx and shoving them under the rug in any way. One of the MAJOR purposes of this group is to discuss side effects. We're here to help one another, to share useful information and offer support. Abbas, however, has a different agenda - I have no idea what it is, but it doesn't belong here. I think he posts on the net to make sick people feel bad - in other words, he's on a power trip of some sort. We should stop responding to him.
577132 tn?1314270126 Shiffman, MD Impact of adverse events and dose reduction As opposed to interrupting or prematurely stopping ribavirin, which enhances breakthrough and relapse, recent data suggest that merely reducing the dose of ribavirin in response to adverse events does not significantly affect these milestones, and therefore has little impact on the SVR.
Avatar f tn Vertical transmission of hepatitis C from an infected mother to her child occurs in less than 10% of pregnancies. The is a tough break to have got it from your mother. I'll let others comment on typical side effects of treatment. So you are on the transplant list at Mayo correct? Your hepatologist at Mayo is going to treat you? Correct? FYI: I've never heard of cirrhosis in less than 20 years and being in someone so young. Is hepatitis C the only cause of all your liver disease/cirrhosis?
446474 tn?1446351282 Both sofosbuvir in combination with ribavirin and sofosbuvir in combination with GS-5885 and ribavirin were well tolerated in the ELECTRON study. In the sofosbuvir combined with GS-5885 and ribavirin groups, there was one discontinuation due to an adverse event unrelated to study drugs. Despite stopping therapy at week 8, this patient also achieved SVR4. The most common adverse events were headache, fatigue, upper respiratory tract infection and nausea.
446474 tn?1446351282 SO would you please confirm for everyone that ribavirin is an easy drug to take and it has no terrible side effects the way people have been saying it does. The only time that happens is when it is taken with Interferon. Truly, of all the people on the study with me, NONE of us had any side effects to speak of. Can you please confirm that because no one seemed to believe me. Thank you.
Avatar f tn The antiviral effect was not significant. No adverse clinical effects or significant laboratory values were observed. Oral treatment of patients with influenza A or B infection might be possible with ribavirin.
Avatar m tn That is 12 weeks less time dealing side effects if a person can tolerate 12 weeks of Ribavirin. Plus a reduced cost of treatment. ------------------------------------------------------------------------------------ For those with HIVHCV -COINFECTION http://www.hcvguidelines.org/full-report/unique-patient-populations-patients-hivhcv-coinfection ........ UNIQUE PATIENT POPULATIONS: PATIENTS WITH HIV/HCV COINFECTION Recommended regimens for HIV/HCV-coinfected individuals.
7829857 tn?1401196259 What was your hemoglobin after 4 weeks? Anemia and rash would be the major averse effects with Ribavirin. Have you looked at FULL PRESCRIBING INFORMATION FOR OLYSIO Established and Other Potentially Significant Drug Interactions and checked all the drugs listed to see if you are also using any of these. Are you drinking at least 6 to 8 glasses of water every day 48 to 64 oz? Are you taking any med for your pain?
583625 tn?1221086929 DeLeve Page 63 Interferon-alpha inhibits the transcription of mitochondrial DNA into mitochondrial transcripts, thus decreasing mtDNA-encoded respiratory chain polypeptides and mitochondrial respiration. Some of the adverse effects of Interferon-alpha, such as minor blood dyscrasias, myalgias, paresthesias, convulsions, and depression, resemble those observed in mild forms of inborn mitochondrial cytopathies.
Avatar f tn "But I do take issue that this discussion group mostly represents those who have had side effects on the more severe side" hi Jim, this place IS a life line to me,,,BUT I was 'trying' to point out that we do not have enough posts from people when things are going good. They are important also. That's part of the reason so may people fear treatment,I believe.Thats why I wanted to make sure i posted that my start was fine, 'for the ones waiting to tx.
Avatar n tn due to new data which showed adverse liver effects). Hang in there.
Avatar f tn Then by coincidence, today I'm reading a list of side effects of Ribavirin given to me by the nurse. Third on the list of side effects experienced by up to 64% of patients is hemolysis! Bingo - so the Procrit is stimulating the the production of rbc and raising the hemoglobin. The ribavirin is causing the hemolysis which is resulting in higher blood ammonia levels - which is likely the reason he has been having these episodes of HE weekly lasting several days.
Avatar f tn I finished my eleven months treatment for hep c(ribavirin &pegintron) 4 months ago and have been plagued with life changing side effects ever since. Extreme tiredness...I can sleep 12-14 hours everyday and still want a nap...I forget things all the time; go into a room and don't remember why, forget conversations I had yesterday...aches and pains...vision loss, weight gain. I read the same complaints from others on the MedHelp forum and the outlook does'nt seem positive.
29837 tn?1414538248 I hope this helps you. SIDE EFFECTS Clinical Trials Experience The most common adverse reactions ( ≥ 10%) were fatigue and headache in subjects treated with 8, 12, or 24 weeks of HARVONI. Table 2 lists adverse reactions (adverse events assessed as causally related by the investigator, all grades) observed in ≥ 5% of subjects receiving 8, 12, or 24 weeks treatment with HARVONI in clinical trials. The majority of adverse reactions presented in Table 2 occurred at severity of grade 1.
5524415 tn?1372335990 I can still hear the specialist saying to me in my first appointment, 'there's hardly any side effects now, noooo.....'. How can a professional say that, who is prescribing this treatment... Is she just lying and why?
Avatar f tn T Ide, T Okamura, R Kumashiro, Y Koga, T Hino, A Hisamochi, K Ogata, K Tanaka, R Kuwahara, R Seki, M Sata Second Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan. One of the major side effects of ribavirin/interferon alpha combination therapy for chronic hepatitis C is hemolytic anemia.
1893294 tn?1321220750 ABT-267 4. ABT-333 with or without Ribavirin. He said it is phase III trial and SVR12 rates were more than 90% . All meds are oral and no grand side effects... but doc couldn't show me phase II results and i could not find any information on internet. Anyone knows this trial? (31 yrs old, white male, naive, 1.000.
Avatar f tn • 2 people receiving sofosbuvir/ledipasvir alone and 2 receiving ribavirin experienced serious adverse events, but no one discontinued treatment for this reason. • Grade 3-4 adverse events (0% vs 14%) and grade 3-4 laboratory abnormalities (7% vs 14%) were more common among those taking ribavirin. • Anemia was seen only in the ribavirin arms (19%).
Avatar f tn this month, results of the ELECTRON Study demonstrated a 100% rate of SVR12 in G1 patients who were previous non-responders with fibrosis and Cirrhosis. Link is at the bottom.
766573 tn?1365170066 In clinical trials, the incidence of adverse events of at least moderate intensity was higher in the telaprevir group than in the placebo group (both groups receiving peginterferon alfa and ribavirin). The most frequently reported moderate adverse reactions (incidence ≥ 5.0%) were anaemia, rash, pruritus, nausea, and diarrhoea, and the most frequently reported severe adverse reactions (incidence ≥ 1.0%) were anaemia, rash, thrombocytopenia, lymphopenia, pruritus, and nausea.