Unfortunately, in 2002 when your wife first started with Lamivudine, antiviral treatment was still somewhat new and probably didn't fully understand what resistance means (and sadly some still don't). And in 2002, Adefovir was approved for treating HepB. Lamivudine has has a poor resistance profile. We know that now but can't turn back the clock.
Now, I am NOT a doctor. But I read that Telbivudine is okay to use during a pregnancy. So ask your wife doctor about that option.
t find a lot of information online on treatment during pregnancy, but she told me there has been studies and it's safe. The other thing that I'm scared about is breastfeeding after giving birth. I am told that it is okay to breastfeed even if you are HBV positive. My concern is this; I did some research and found that it is not good to stop medication, which is what I thought I would do after giving birth so that I can breastfeed.
I understood from my family doctor (not a liver specialist) that Lamivudine has the least side effect and is the safest among other medicine types for husband and wife who wish to have children. And yes, I understand the "high resistance" issue, but given the pro and cons comparing to other medicine, it seems to me that is the best choice to start. Am I (and my doctor) correct?
you need hbvdna to judge first, although lam is very weak and not used anymore even for pregnancy it is possible you are among the responders.
the problem with hbvdna is that good labs have it in few days while bad labs/hospitals are slow with the test because pcr is very expensive and they wait to have many test requests to save money on the pcr...
no these drugs make untreatable virus mutants, this was a failure on hiv and hbv and should never be used now
sorry a big mistake i did here, this drug lamivudine make untreatable virus mutants, this was a failure on hiv and hbv and should never be used now.
Doctor recommended lamivudine in January. Took lamivudine and by June 2010, viral load was undetected. have read in many forums that lam is not the best, approached my doctor with this concern and she sugessted tenofovir. Should i start tenofovir immediately, how should i start. Should i just abruptly stop lam and move on to tenofovir, should i use both and gradually stop lam after a few day/weeks. No other options here. Nigeria (Africa), so i cannot combo with other drugs.
now my ALT is normal, HbeAg is negative Anti-HBe is negative and may DNA is below 6 units but my HbsAg is still positve and Anti-Hbs is negative. Can you please tell me what are the things to be done in order my HbsAg will become negative and my Anti-Hbs will become positive.is it true that REST is one thing am i going to do because i am always tired with my work.
5 year combo with interferon) and drop from couple of milions to 1000 copy and the children (lamivudine mono) clera the infection and seroconvert to HbsAb.
Hello Doc, am 28yrs Male from Africa Uganda,8 days ago i got sexually involved with a girl of 19yrs we used a condom for most of the intercourse but before i climaxed my condom broke at bottom tip, am not sure how long i lasted their in her virgina after my condom broke cos i was drunk but it was around 5 mins when i realized my penis head was not covered i did not continue sex stoped there and i did not cum cos i got scared right away ,then the following day i took her to test and she turned ou
HBV DNA clearance was assessed using assays with different sensitivities to detect HBV DNA. Adefovir and lamivudine increased HBV DNA clearance at end of treatment versus placebo. Entecavir increased clearance versus lamivudine with inconsistent effect size. Lamivudine was less effective than adefovir in lamivudine-resistant patients and less effective than telbivudine in HBeAg-positive patients.
Lamivudine is outdated and ur virus will multiply anyway someday due to resistance to it so best is change to tenofovir and also change ur doctor who even don't know in today's time lamivudine is not used.
D Doctor advised me to use Lamivudine which I did. Two months ago i did the test again and it showed that I am positive. I was advised to do Liver scan and HBD DNA Viral Load. The scan showed that my Liver is ok. The viral load is 991. I want to try Liv. 52 and Liv. 52H. Has anyone used them before?
once the lamivudine has been started it is difficult to discontinue it without changing it to another medication. it is possible that you have developed resistance and may need to check a viral level and if (+) be switched to another medication. Resistance is very common with lamivudine use. a CT scan or U/s should also be checked.
Even when lamivudine was resumed, it did not stop the rise in ALT, which then down eventually, but the bilirubins did not. May be compensated cirrhosis patients should never stop therapy, and those on lamivudine should switch to a drug with a higher barrier to mutation?
1. I am HBV carrier, and I am also under treatment with taking lamivudine 100mg daily. Will this impact the result? Will lamivudine/HBV virus cause false negative?
2. Because I am taking lamivudine daily, will this cause the delay of seroconversion. I think the test was done about 18 months after events that I thought maybe risky.
3. My test is Combo TypeI/II antibody and p24 antigen QUAL CMIA. Is it reliable?
4. My HBV DNA level is sometimes undetectable, but sometime a few hundreds.
lvd is not the first choice and it stops working after years of use due to the fact virus develpos resistance.
you can use entecavir or any other antiviral after using lamivudine you have only tenofovir left that works, entecavir will create a monster mutant virus with other 4-8 or more mutations
I was examined by my first doctor and advice me that I am not qualified for medication but my employment requires to pass this Hepa B case so I look for another doctor that could give me something for medication.. The doctor and give me Lamivudine(Zeffix)..
My question is; Is there someone in this forum that had experience with this level of UI/ml that been cured and how long?.. My employeer is waiting for my respond but I cant give them exact or approximate date when will cured..
I guess fatty food is the cause of ALT elevation. I said NO to alchol long ago. I will have to pay attention to what i eat , work-out a little more and see if the numbers will go down.
I have taken note of your suggestion to try interferon. I will discuss that with the doc. on my next appointment. Lamivudine like you said would be a last choice. I did some research and concluded that wouldn't be a wise choice.
Hope you're doing great?
But in short, seroconversion from HBeAg to HBeAb COULD be an endpoint of lamivudine treatment. But no guarantee.
After treatment HBV, I took lamivudine 100 mg/day DNA/HBV is negative since May 2008. Successive (check blood DNA HBV Every 3 months).
Now after I stopped using lamivudine 2 months
-DNA/HBV: 280,000 Copies = 2,8 x 5log10.
-SGOT : 140 ui
-SGPT : 300 ui
Should I take tenofovir 0,5 mg alone or plus lamivudine 100 mg ?
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