stop lamivudine immediately or switch to tenofovir, it is decades now lamivudine is not used because it can lead to cytopatic hbv mutations that cannot be control with any medication leading to cancer and cirrhosis despite hbsag negative, hbvdna undetectable and normal ast-alt, another reason not to use lamivudine is that it is even totally useless on hbv
the hbsag of the virus mutates to a form where the virus destroy cells directly even without replication
hbv cure is achieved only by sequen
lamivudine is not an hbv drug anymore, ban of it has been proposed already because it only worsen the infection
the only drugsare: tenofovir, peginterferon, entecavir, none is curative except two cases:
peginterferon when hbsag is less than 1000-1500iu/ml
sequential treatment of 3 years tenofovir or entecavir and peginterferon add on 1-2years (5years total)
be aware most liver specialist are ignorant about hbv and poor countries have corrupt doctors prescribing damaging drugs, tenofovir gener
She has also been a patient of anemia.For the last 1.5 years she has been on lamivudine 100 after her hbv dna crossed 86 lacs. iu/ml in 2012.So far everything has been fine,the liver enzyme levels(AST/ALT/ALP) have nearly normalized,platelet count has increased.But one day ago she underwent a blood test and found that:Sgpt=206,Sgot=131,Alk. phosphatase=88,serum bilirubin total=0.9...While alk.
Lamivudine monotherapy failed to sustain seroconversion. Interferon alfa- 2b plus lamivudine demonstrated inconsistent effects on seroconversion at 6-28 weeks of followup with significant benefit in a pooled analysis from four RCTs using individual patient data. Telbivudine versus adefovir or peginterferon alfa-2a versus lamivudine increased post treatment HBeAg seroconversion.
Sensitivity analyses confirmed the robustness of the results. There were no serious adverse effects being reported. Lamivudine resistance was from 28.6% to 37.5% but could be rescued by other types of NA or combination therapy.
CONCLUSION:
Our study suggested benefits of adjuvant NA therapy following curative treatment of HBV-HCC.
Doc, my girl friend has taken all the vaccines against hepB but i am under treatment. can we give birth to a non-reactive baby? I take lamdek(lamivudine 100mg) one per day, how effective is it? I am experiencing some minor pains below my chest. is my condition deteriorationg? I do jogging for half a mile every saturday in addition to other exercises..what are the effects on my health? sorry for the many questions. Thanks.
About one year ago when I conducted Hepatitis B profile, I had NON RELICATIVE INFECTION but about one year on lamivudine I am now REPLICATIVE. Please what does this suggest? I am planning to stop taking lamivudine because it gives me so much side effect ranging from stomach discomforts and back pains and general weakness. The doctor I met this time related all these complaints to lamivudine.
BACKGROUND: Nucleoside analogues such as lamivudine for chronic hepatitis B have an excellent safety profile while patients are on therapy but reactivation flares occur in 19-50% of patients after stopping therapy, some of whom develop liver decompensation. AIMS: To describe and report three cases who developed fatal hepatitis B reactivation after stopping nucleoside analogue therapy.
they induced strong inhibition of viral production at concentrations at which host cell viability was not affected (artemisinin and artesunate). Moreover, artesunate in conjunction with lamivudine had synergic anti-HBV effects, which warrants further evaluation of artemisinin/artesunate as antiviral agents against HBV infection.
Intriguingly, 25, 39, 48, and 49 retained sensitivity against lamivudine-resistant HBV containing a single mutation (M204I) and 48 emerged as an effective inhibitor of drug-resistant HBV with an EC(50) of 4.1 μM. In contrast, 50% inhibition could not be achieved by lamivudine at 44 μM concentration in the drug-resistant strain. The compounds investigated did not show cytotoxicity to host cells up to the highest concentrations tested.
He has only asked me to take a liver supplement ursodiol 300 for the next three months.I consulted another doctor who asked me to continue with my lamivudine 100 throughout my life.Now I am getting confused what to do now,whether to stop taking it temporarily or continue it?Can such kind of drugs be taken throughout life?I mean they might have side-effects,resistance etc....
95% CI, 0.78–1.28). However, entecavir and lamivudine did not have significantly different effects on clinical outcome in 878 pairs of patients without cirrhosis.
Conclusions
In a retrospective study of 5374 patients with chronic hepatitis B virus infection, entecavir therapy was associated with a significantly lower risk of death or transplantation than lamivudine. However, the drugs did not have different effects on HCC risk.
http://www.sciencedirect.
1%) had spontaneous abortion at the first trimester. Maternal and fetal adverse events are shown on Table 1. Most adverse events were mild in severity and considered unrelated to TDF. A higher percentage of mothers achieved HBV DNA 9. Among the 19 infants that have since reached the age of 7 months, 18 were tested and all were HBsAg(-).
Conclusions:
TDF treatment for the entire pregnancy period is safe and well-tolerated in pregnant women with active CHB.
Without taking any drugs, viral load was 22,000 in september 2009. 46,000 in december 2009. Doctor recommended lamivudine in January. Took lamivudine and by June 2010, viral load was undetected. have read in many forums that lam is not the best, approached my doctor with this concern and she sugessted tenofovir. Should i start tenofovir immediately, how should i start. Should i just abruptly stop lam and move on to tenofovir, should i use both and gradually stop lam after a few day/weeks.
Recommended
