interferon beta 1b standard

The current guidelines for treating Genotype 1a or 1b is the triple medication regimen using Interferon, Ribavirin, and a protease inhibitor (either Incivek or Victrellis). The triple med regimen has been the treatment for Genotype a since June 2011. (Approved in May 2011).

Studies conducted at the author’s center longer than a decade ago demonstrated that increasing the dosage of standard interferon from 3 to 5 to 10 mU and then to 20 mU three times weekly every 3 months in those patients who remained HCV RNA positive led to a stepwise increase in the overall percentage of patients becoming HCV RNA undetectable. Up to 80% of patients treated with this approach eventually became HCV RNA undetectable.

As i said I have genotype 1b. I still dont really understand what 1a and 1b really means. Is 1b harder to be treated than 1a or viseversa. Im also willing to do any trails take one for the team.

Hi, my daughter diagnosed hep C in 2007, she has geno type 1B. They ran a bunch of test before start her treatment. The test came back with genotype is 6 !!! Where is the 1B go? we gonna see her doctor in couple weeks. Is anyone experience something like this? Is the 1B is gone or, she hase both 1B and 6 now...... Any input is appreciated... W.

Also, the type of interferon used is different than that in Betaseron. Betaseron is interferon beta-1b NOT interferon beta 2-b. These little points are important. Also, in discussing male sperm counts and motility one must consider many, many factors - not just the most notable med the person is on. A man's sperm count and activity may be affected by things we don't even think about like temperature, alcohol, depression, meds like anti-depressants or antihypertensives.

Here, we describe for the first time a case of sustained virological response (SVR) achieved in a patient with chronic hepatitis C (CH-C) by monotherapy with a NS3-4A protease inhibitor, telaprevir, without interferon therapy. A 59-year-old treatment-naïve Japanese man was enrolled in a phase II trial of telaprevir by repeat oral administration at a dose of 750mg every 8h for 24 weeks. At the start of treatment, he exhibited a low-level viremia with genotype 1b of the hepatitis C virus (HCV).

My husband got his first blood test results with an "ALT 58". after that he got Hep B surface antibody ql "reactive". Hep C antibody "reactive" as well. The signal to cut-off was "27.70". After that his viral load showed "HCV RNA PCR QN 85200 <43 IU/ML" and also "4.93 <1.63 LogIU/mL". Also HCV Genotype, LIPA - "GENOTYPE 1B". We haven't seen the doctor yet.

I am no expert, but since three of the CRAB drugs are interferon beta (either 1a or 1b), they should all have the similar benefits/risks.

Metavir A3/F3 means you have severe liver inflamaton and septal fibrosis or advanced liver disease stage 3 which is one stage below cirrhosis. You are from Kenya and the most common genotype is 4. Currently, they are treating that genotype with interferon and ribavirin as well as genotype 2 & 3. If you are genotype 1, the standard of care is triple therarpy using a protease inhibitor, either Victrelis or Incivek in conjunction with interferon and ribavirin.

On December 19th, GlobeImmune announced the initiation of a phase II study expected to enrol 120 patients who will receive Tarmogen in combination with pegylated interferon plus ribavirin and compare the triple to regular standard of care (peg with ribavirin). (December 28, 2007) As for choosing a drug trial, there are two other trials either recruiting now or will be soon that you should also look into. Both of these show great promise.

Recent studies have suggested that a person’s HCV subtype is the key-factor that influences their possible response to interferon, or interferon-ribavirin combination treatment. It is very important to find out which genotype you carry. Most of us learn about Hepatitis C as one disease, however in actuality it's really several different strains of a virus. They are all similar enough to be called hepatitis C virus, yet different enough to be classified into subgroups.

The Abbott-funded research found that eight of 17 patients who didn’t improve on standard-of-care treatments had no detectible virus levels after three months on the therapy, which combines two products, the Abbott Park, Illinois-based company said in a statement. Abbott rose less than 1 percent to $61.69 at 10:49 a.m., after jumping 2.3 percent to $62.57, the highest price since at least 1980, according data compiled by Bloomberg. Abbott, Bristol-Myers Squibb Co. (BMY), Gilead Sciences Inc.

The HCVerso clinical trial program includes two pivotal Phase 3 IFN-free studies that will enroll approximately 1,000 treatment-naive HCV genotype-1b (GT-1b) patients, including those who are interferon eligible or ineligible.

Incivek and Victrelis are Protease Inhibitors and they are used in people with Genotype 1. The Standard of Care for Genotype 1 is currently Interferon, Ribavirin, and a Protease Inhibitor (either Incivek or Victrelis). That is the Standard of Care for people with Genotype 1 regardless of previous treatment or viral load or fibrosis stage (including compensated cirrhotics) (even Crossroads treated and she had decompensated cirrhosis).

Here are a couple of links to discussion of abbreviated, 24 week therapy for a subgroup of GT-1 patients using the current standard of care interferon/ribavirin treatment: http://www.hivandhepatitis.com/hep_c/news/2008/101408_b.html http://www.hivandhepatitis.com/2009icr/aasld/docs/111709_a.

s the interferon part of the med which causes depression, so yes, I would expect that Betaseron (interferon-beta-1b) would be more likely than Rebif to cause the problem as it is the highest dose of all. You are very welcome - in all ways.

Even though you had low baseline viral load and was RVR? What was your baseline? Remind me. I know you were looking for studies for geno 1b RVR low viral load. Did your research make you decide to go the full 48?

Interferon beta 1b standard

Common Questions and Answers about Interferon beta 1b standard

betaseron