Interferon beta 1a and 1b

Common Questions and Answers about Interferon beta 1a and 1b

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Hi there and I am a 1b and cleared over two years ago with interferon & Riba...I have a PCR every 6 months to check I am still clear as my hubby has HepC he is geno 1a...

http://www.fiercebiotech.com/story/year-after-11b-buyout-gilead-track-blockbuster-hep-c-program/2013-01-07?utm_source=rss&utm_medium=rss This is all I could find so far...

I am no expert, but since three of the CRAB drugs are interferon beta (either 1a or 1b), they should all have the similar benefits/risks.

5% with ribavirin and 99.0% without ribavirin) and among those with genotype 1a infection (97.0% and 90.2%, respectively). Of patients with genotype 1b infection, 1 had virologic failure, and 2 did not have data available at post-treatment week 12. Among patients with genotype 1a infection, the rate of virologic failure was higher in the ribavirin-free group than in the ribavirin group (7.8% vs. 2.0%). See full article here: http://www.nejm.org/doi/full/10.1056/NEJMoa1402338?

I am cirrhotic, 1A, and failed both single Interferon (when stage 1) and double Inter/Ribaviron (when stage 2) tx's over the years. This time around (2011-12) with triple tx. my Incivek was abreviated from the standard 12 weeks to 9-10 weeks because of side effects (primarily anemia). The remaining Interferon and Ribavirin. was much much easier to tolerate for the rest of the 48 weeks. I became undetectable 3 weeks into therapy and remained undetectable 7 months post tx a.k.a.

This suggests to me that genotype 1 may need to be cleaved further into 1a/1b subtype distinctions for future clinical trials, and I can envision that DAA regimens may even be tailored to HCV subtype. In current practice, we routinely obtain subtype information with our genotype assays, so no additional information generally needs to be requested.

I am a guy from Finland and I start my interferon + riba day after tomorrow. My genotype is 1b. I am nervous about side effects. I hope that they are not hard for me. Have a good summer everybody!

I started out at the very beginning with genotype 1A and 1B. After many, many treatments, I finally cleared the 1B, but the 1A has remained resistant to the 10 treatments that I've tried. As NYGirl said above, it depends on the individual and how that person's immune system handles it.

t getting the placebo either but remember there are loads of us in here who have cleared and been cured who never got anything other than regular old interferon and ribavirin - so there is plenty of hope for you anyway :) You said you just started to feel bad. Bad like how? tired and lethargic or feverish or something?

Recommended regimens for patients with HCV genotype 1a or 1b infection who have compensated cirrhosis, in whom prior PEG-IFN and RBV treatment has failed." "Daily fixed-dose combination of ledipasvir (90 mg)/sofosbuvir (400 mg) for 24 weeks is recommended for patients with HCV genotype 1a or 1b infection who have compensated cirrhosis, in whom prior PEG-IFN and RBV treatment has failed.

As i said I have genotype 1b. I still dont really understand what 1a and 1b really means. Is 1b harder to be treated than 1a or viseversa. Im also willing to do any trails take one for the team.

s first interferon-free regimen for genotype 1 (1a and 1b) patients by the end of 2014 or beginning of 2015, pending regulatory discussions. " It looks to me as though there could be several forms of interferon free treatment on or about 2015; Vertex, Gilead, possibly BMS or Abbott and possibly a few others.

1A is one of the subtypes of genotype 1 (there is also 1B) Although treatment of g1 has a lower success rate than other genotypes, 1 is the most common genotype in North America, and many, many people have treated it successfully. I had genotype 1A and I cleared the virus. Before you make treatment decisions you should have a biopsy to find out how much liver damage you have, if any.

t know phenotype, but he was a partial responder in two previous therapies (1st SOC, and 2nd daily infergen injections - infergen is another variety of interferon - and 1400 mg. ribavirin) It is my husband who is treating, not me.

The current guidelines for treating Genotype 1a or 1b is the triple medication regimen using Interferon, Ribavirin, and a protease inhibitor (either Incivek or Victrellis). The triple med regimen has been the treatment for Genotype a since June 2011. (Approved in May 2011).

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