interferon beta 1a vs 1b

m not an expert, but i do (hopefully did) have 1b...my dr said that 1a needs one mutation to replicate while 1b needs 2 mutations to replicate making 1a more difficult to treat.

The most common events in the 12- and 24-week groups were fatigue (32.7% vs 46.5%), headache (27.9% vs 30.8), and nausea (in 17.8% vs 20.3%). Hemoglobin levels below 10 g/dL were less common in the 12-week than 24-week group (7.2% vs 11.0%), and were managed with a ribavirin dose reduction. Most adverse events were mild to moderate. There were more serious adverse events in the 12-week than the 24-week group (6.2% vs 4.7%), which led to discontinuation in about 2% of each group.

for prior null responders - 27% SVR for 1a vs 37% for 1b; for partial prior responders - 47% for 1a vs 68% for 1b; for relapsers no real difference - 84% for 1a vs 88% for 1b. - cirrhotics did not do as well if they were prior partial responders or null responders but did the same if they were prior relapsers. Partial prior responders: 72% SVR if no or minimal fibrosis; 56% SVR with bridging cirrhosis; 34% if cirrhotic.

Methods We randomly assigned 419 patients with HCV genotype 1b infection (PEARL-III study) and 305 patients with genotype 1a infection (PEARL-IV study) to 12 weeks of ABT-450/r–ombitasvir (at a once-daily dose of 150 mg of ABT-450, 100 mg of ritonavir, and 25 mg of ombitasvir), dasabuvir (250 mg twice daily), and ribavirin administered according to body weight or to matching placebo for ribavirin.

As i said I have genotype 1b. I still dont really understand what 1a and 1b really means. Is 1b harder to be treated than 1a or viseversa. Im also willing to do any trails take one for the team.

66-70% for 1b vs. 59 -63 % for 1a The above reflects results for treatment naive patients and irrespective of other facors involved.... I will copy the data article later so you are not talking my word for it busy at the moment tho..

Due to a somewhat lower genetic barrier to the emergence of resistance, patients infected with genotype 1a HCV tend to fare less well, as reflected by the SVR rates, which were approximately 7% lower in genotype 1a patients compared with 1b patients For telaprevir.........The presence of drug-resistant variants at treatment failure was less likely with subtype 1b vs 1a HCV infection. In addition, subtype 1b was found to revert to wild type more quickly than subtype 1a (P < .0001).

http://www.fiercebiotech.com/story/year-after-11b-buyout-gilead-track-blockbuster-hep-c-program/2013-01-07?utm_source=rss&utm_medium=rss This is all I could find so far...

I am no expert, but since three of the CRAB drugs are interferon beta (either 1a or 1b), they should all have the similar benefits/risks.

0001)[8], with patients nearly twice as likely to remain relapse-free for more than two years compared to those receiving placebo (31% vs. 16%, p=0.007)[8]. In addition, treatment with interferon beta-1b may slow disease progression[9]. After two years, almost three-quarters of patients who experienced a single episode of neurological disease lasting 24 hours or more did not progress to clinically definite MS[10].

I started the Sovaldi/Ribavirin/Interferon treatment 5/16. I finish this Thursday, 8/7. I am 1a, early cirrhosis, 2 prior treatments. I was Undetected at week 4 and my liver and kidney function tests are better than they've been in years. We shall see what my post treatment tests show! I am hopeful, but realistic.. :) This is just my story and the path my doctor and I chose. I trust him and will keep on the fight! You're question is a good one and I'm glad you asked.

Those who have Genotype 1 can be sub-typed further into Genotype 1a or Genotype 1b. Genotype 1b is easier to cure than Genotype 1a. The reason for this is that the resistant strains do not develop as easily in those with Genotype 1b as they do in Genotype 1a. One can also be sub-typed further into CC, CT, or TT. CC is easiest to treat. However, all of this does not mean people with Genotype 1a who are also CT or TT cannot be cured. They can be.

I am a guy from Finland and I start my interferon + riba day after tomorrow. My genotype is 1b. I am nervous about side effects. I hope that they are not hard for me. Have a good summer everybody!

Can I just say this to you terca, I think that alot of the factors involved with beating the Hep-C dragon has to do with being totaly focused on the goal & being very optermistic you will win .... Like it was said the figures we read about are years old & I'm sure they must be better than a flip of a coin nowadays (with geno 1a & 1b) Good Luck to you I'm geno 3a but on my 2nd Tx 4 weeks away from the finish line 48wks Arrggghhhh yeehaa .... Steve ....

Recommended regimens for patients with HCV genotype 1a or 1b infection who have compensated cirrhosis, in whom prior PEG-IFN and RBV treatment has failed." "Daily fixed-dose combination of ledipasvir (90 mg)/sofosbuvir (400 mg) for 24 weeks is recommended for patients with HCV genotype 1a or 1b infection who have compensated cirrhosis, in whom prior PEG-IFN and RBV treatment has failed.

My first was in 1995, I responded and then I relapsed. I know that my Genotype (1a, 1b) is more difficult to treat. Does anyone that has (had), my Genotype have any encouraging stories to share about their success with the Pegylated Interferon treatment. I'm very anxious about starting treatment again because I was so sick the first time I took it. Thanks for your help.

s first interferon-free regimen for genotype 1 (1a and 1b) patients by the end of 2014 or beginning of 2015, pending regulatory discussions. " It looks to me as though there could be several forms of interferon free treatment on or about 2015; Vertex, Gilead, possibly BMS or Abbott and possibly a few others.

This is bad news but not the end of the world. 1A is one of the subtypes of genotype 1 (there is also 1B) Although treatment of g1 has a lower success rate than other genotypes, 1 is the most common genotype in North America, and many, many people have treated it successfully. I had genotype 1A and I cleared the virus. Before you make treatment decisions you should have a biopsy to find out how much liver damage you have, if any.

Interferon beta 1a vs 1b

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