how does interferon beta 1a work

http://health.usnews.com/health-news/news/articles/2012/04/19/early-use-of-ms-drug-may-cut-likelihood-of-progression THURSDAY, April 19 (HealthDay News) -- A new three-year study finds that a multiple sclerosis drug is more likely to prevent patients from progressing to a definite form of MS if it's given early in patients who appear to be ill. The drug, a form of interferon called "interferon beta-1a," is not available in the United States.

Are you facing a decision about choosing a med? Of the four approved for use in MS, three are Interferons (specifically beta-1a) and one, Copaxone is not. They are all about equally effective in RRMS. Do you have concerns about being on an interferon?

In this post-hoc study, MRI scans were analyzed from patients with relapsing MS participating in a placebo-controlled trial of interferon beta-1a. The brain parenchymal fraction, defined as the ratio of brain parenchymal volume to the total volume within the brain surface contour, was used to measure whole brain atrophy. The relationship between disease features and brain atrophy and effect of interferon beta-1a were determined.

I am no expert, but since three of the CRAB drugs are interferon beta (either 1a or 1b), they should all have the similar benefits/risks.

) Pharmacokinetics The pharmacokinetics of Rebif® (interferon beta-1a) in people with multiple sclerosis have not been evaluated. In healthy volunteer subjects, a single subcutaneous (sc) injection of 60 mcg of Rebif® (liquid formulation) resulted in a peak serum concentration (Cmax) of 5.1 ± 1.7 IU/mL (mean ± SD), with a median time of peak serum concentration (Tmax) of 16 hours.

one study i looked at said that a dose of 30 micrograms/week of IM interferon beta-1a was well tolerated but a dose of 60 micrograms/week caused severe flulike symptoms and elevated liver enzymes. im assuming that this type is similar to infergen, really strong. it seems like pegasys and pegintron dosages are somewhat similar.

Earlier Phase 2 studies showed that treatment with alemtuzumab reduced the accumulation of disability and the frequency of relapses in people with early relapsing-remitting MS, compared to Rebif® (interferon-beta-1a-rebif/index.aspx, interferon beta-1a, EMD Serono, Inc. and Pfizer, Inc.). (New England Journal of Medicine 2008 359;17:30-45) Rebif is a registered trademark of EMD Serono, Inc. and Pfizer, Inc. http://www.nationalmssociety.org/news/news-detail/index.aspx?

Trial 108 (ADVANCE) Trial 108 was a randomized, double-blind, parallel-group, placebo-controlled trial conducted in treatment-naïve subjects (had received no prior therapy for HCV, including interferon or pegylated interferon monotherapy). Incivek was given for the first 8 weeks of treatment (T8/PR regimen) or the first 12 weeks of treatment (T12/PR regimen) in combination with Peg-IFN-alfa-2a/RBV for either 24 or 48 weeks.

I have been treating my multiple sclerosis (MS) with avonnex (interferon beta-1a) for the past ten years. I have had four severe flare ups, three in the first four years and one in the last six months. which I needed physical therapy to walk again. In 2003 I was diagnosed with Hep C, it has recent progressed to stage 3 fibrosis. I have a reason to believe that my MS treatment is damaging my liver and causing my fibrosis to advance.

I was told by the doctor that I am in the middle of the scale for liver damage do to hepatitis C. On a scale from 0 to 4 I am a 2 and I have type 1a which is resistant to treatment, stubborn. I was told by my doctor that a new treatment is in the works and that I should wait about year and see if any thing in this area of treatment has changed. Meanwhile I should get a blood test every 6 month to check on my liver.

You are taking rebif, which is interferon beta-1a used for relapsing MS. you could be suffering from jaw muscle spasms causing tongue and lip bites. You may be experiencing numbness in the tongue, a common symptom of multiple sclerosis per se. Review with your neurologist if your disease spectrum has changed and for these newer symptoms. He might like to add some muscle relaxant like tizanidine, baclofen or carbamazepine. You are welcome with any further clarifications. God bless.

The standard therapy options include intravenous immunoglobulin and plasmapharesis, corticosteroids, azathioprine, cyclophosphamide, etanercept, mycophenolate mofetil, interferon alpha 2a and tacrolimus. Current ones are interferon beta 1a, rituximab, and high dose cyclophosphamide. Your neurologist needs to apprise you of the long-term side effects since prolonged therapy are required. Botox shots are not known to be used in therapy.

I completed Interferon-Ribavirin-Neupogen 2 years ago in Feb...My WBC, RBC, Platelets, and Absolute neutrophil counts have been down most of the time since completing 48 weeks. I was to have cervical surgery for severe stenosis this week but they did my lab work 2 times last week and cancelled the surgery. I know it is very dangerous for bleeding or hematoma of spinal cord..Do you have any idea why my labs stay like this? RBC 3.2, Hgb 10, Hct 30, platelets 130, and Absolute neutrophils 1.5.

Bad news, but there is hope. Worth trying treatment to see how you respond, it worked for me (I was 1A), I hope it does for you.

I am a guy from Finland and I start my interferon + riba day after tomorrow. My genotype is 1b. I am nervous about side effects. I hope that they are not hard for me. Have a good summer everybody!

How does interferon beta 1a work

Common Questions and Answers about How does interferon beta 1a work

rebif