interferon beta 1a and liver disease

I was told by the doctor that I am in the middle of the scale for liver damage do to hepatitis C. On a scale from 0 to 4 I am a 2 and I have type 1a which is resistant to treatment, stubborn. I was told by my doctor that a new treatment is in the works and that I should wait about year and see if any thing in this area of treatment has changed. Meanwhile I should get a blood test every 6 month to check on my liver.

On a 10-point scale of disability, the mean score significantly improved by 0.39 point in the alemtuzumab group and worsened by 0.38 point in the interferon beta-1a group. The lesion burden (a way of assessing the neurological damage of the disease using a method called T2-weighted magnetic resonance imaging or MRI) in the alemtuzumab group was lower than that of the interferon beta-1a group.

One-third of the study participants received 44-microgram doses of interferon beta-1a three times a week, one-third received the drug once a week and one-third received an inactive placebo for two years until they showed more signs of having the disease. At that point, they got the dose three times a week. After two years, 133 people were still taking a placebo. They were then switched to the 44-microgram dose three times a week.

started explaining end stage liver disease, liver cancer, liver transplants...they guy had me dead and buried! Hm, and he was India(n), too... Then, I found this site. First & formost, There IS hope!. The liver is the only vital organ capable of healing itself, but you have to kill the virus first. Fire this guy you're seeing & find someone who actually cares about your care. there are plenty out there. I found mine thru my local liver foundation & she is a saint.

I have had many labs and one report said I had Genotype 1a and another one said it was Genotype 1b. Does anyone know what is the difference? I was treated with interferon/ribavirin combo for 48 weeks which ended in Sept 2011. Unfortunately, my undetected virus came roaring back 3 months later with 1.4 million RNA PCR and 6.17 RNA log IU/ml This month, my labs came back with 4.6 million RNA PCR and 6.66 RNA log IU/ml.

I have been treating my multiple sclerosis (MS) with avonnex (interferon beta-1a) for the past ten years. I have had four severe flare ups, three in the first four years and one in the last six months. which I needed physical therapy to walk again. In 2003 I was diagnosed with Hep C, it has recent progressed to stage 3 fibrosis. I have a reason to believe that my MS treatment is damaging my liver and causing my fibrosis to advance.

Viral breakthrough happens in 16% of "hard to treat" patients (advanced liver fibrosis, and prior null treatment response) treating with peg-IFN + RBV + Incivek. This happens after treatment with 3 drugs stops and only Peg-IFN + RBV is being used.

) Pharmacokinetics The pharmacokinetics of Rebif® (interferon beta-1a) in people with multiple sclerosis have not been evaluated. In healthy volunteer subjects, a single subcutaneous (sc) injection of 60 mcg of Rebif® (liquid formulation) resulted in a peak serum concentration (Cmax) of 5.1 ± 1.7 IU/mL (mean ± SD), with a median time of peak serum concentration (Tmax) of 16 hours.

MS patients had significant brain atrophy that worsened during each of 2 years of observation. In many patients, brain atrophy worsened without clinical disease activity. Baseline clinical and MRI abnormalities were not strongly related to the rate of brain atrophy during the subsequent 2 years. Treatment with interferon beta-1a resulted in a reduction in brain atrophy progression during the second year of the clinical trial.

You are taking rebif, which is interferon beta-1a used for relapsing MS. you could be suffering from jaw muscle spasms causing tongue and lip bites. You may be experiencing numbness in the tongue, a common symptom of multiple sclerosis per se. Review with your neurologist if your disease spectrum has changed and for these newer symptoms. He might like to add some muscle relaxant like tizanidine, baclofen or carbamazepine. You are welcome with any further clarifications. God bless.

t think it will make it worse and curing the HCV should improve your platelet count and clotting time and make you better able to withstand a future serious back surgery.

Is it true that a person with Hep C and is in end stage Liver Disease is not eligible for a Liver Transplant? I was talking with a friend of mine who had a Liver transplant a little over a year ago because of heavy drinking and presumably snorting Meth for a long time. I told him well if my liver is so bad with fibrosis maybe I can get on the transplant list and he said people with Hep C are not eligible.

Are you facing a decision about choosing a med? Of the four approved for use in MS, three are Interferons (specifically beta-1a) and one, Copaxone is not. They are all about equally effective in RRMS. Do you have concerns about being on an interferon?

I'm also genotype 1a. Up until the protease inhibitors were approved this year the standard treatment for 1a was pegylated interferon and ribaviron. This treatment was only effective in ~50% of 1a patients. Now 1a is treated with a protease inhibitor, pegylated interferon, and ribaviron. I'm in week 8 and treating with Incivek, Peg, and Ribaviron. There are a lot of side effects. The next thing I'd suggest you do is find out how much liver damage you have with a liver biopsy.

It would send me downward very rapidly and advised diet and medication until the new medicines come on board. The interferon is hard on you and causes depressions and hardship on your organs. Go to transplant center, get evaluated first. Then decide. You're not going to die right away, stop drinking if you drink, stop drugs if you take drugs and find out exactly where you are in your disease. There are lots of options ok? Many people will advise you here.

For treatment-naive and prior-relapser patients, a fixed treatment regimen of 12 weeks of OLYSIO™ combined with 24 weeks of pegylated interferon and ribavirin is recommended. For prior partial- and null-responder patients, a treatment regimen of 12 weeks of OLYSIO™ combined with 48 weeks of pegylated interferon and ribavirin is recommended.

If a gastroenterologist is your only option at this time be sure to review and or ask questions about his experience and knowledge about liver disease and new Hepatitis C treatments FYI What Is A Hepatologist ? What Is A Gastroenterologist? http://hepatitiscnewdrugs.blogspot.com/2010/12/what-is-hepatologist-what-is.

His doctor wants him to start asap since he feels if he gets cured it could stop his progression of liver disease. I am very worried for him and I would hate to see him deal with the troubles others are having long term .

In another study, called TENERE, Aubagio was compared with Rebif® (interferon beta-1a, EMD Serono and Pfizer) in relapsing MS, and did not reach its primary endpoint (the main question posed by the study) -- the “risk of failure,” meaning the first occurrence of a relapse, or permanent discontinuation of the study treatment, whichever came first.

Patient response rates to hepatitis C therapy can be variable, depending on factors such as viral genotype and subtype, and liver fibrosis. Patients with genotype 1a, IL28B genotype TT and METAVIR scores of F3 and F4 can be particularly challenging to cure," said Maria Beumont, M.D., medical leader for simeprevir, Janssen. "Janssen is committed to advancing hepatitis C therapy for even the most difficult-to-cure patients.

Can you believe it - 12 weeks with out interferon. It is absolutely unbelievable and about time. I treated with you in 2005 and 6 and failed too. I did clear with Victrelis, but I don't wish either of the PI"s on anyone and am so grateful there is finally a successful treatment without INF. I am not up on this current treatment but you know this is the place to find out.

I am geno type 1a with end stage liver disease. Anyone taking these and what are your symptoms? What can I expect? How many days before you felt different and was it better? I guess I'd like to know what to expect both good and bad. Thank you.

There are other factors too that affect success. Race, degree of liver damage, age and many more. The only way to truly know is to try it and see how a person responds to treatment. Everyone is different and their is no crystal ball to guarantee success or failure. Once he sees how his viral load responders to treatment you will know a lot more. Best of luck to the both of you!

I am 1a, early cirrhosis, 2 prior treatments. I was Undetected at week 4 and my liver and kidney function tests are better than they've been in years. We shall see what my post treatment tests show! I am hopeful, but realistic.. :) This is just my story and the path my doctor and I chose. I trust him and will keep on the fight! You're question is a good one and I'm glad you asked. See what others say and talk with your Hepatologist.

Interferon beta 1a and liver disease

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