Insulin glargine in cats
Common Questions and Answers about Insulin glargine in cats
lantus
This is because the effect described below, of forming microprecipitates below the skin, cannot happen in the blood stream. All the insulin in the blood is available immediately to the body.
Quote from above web page:
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Pharmacodynamics:
Insulin glargine is a human insulin analog that has been designed to have low aqueous solubility at neutral pH. At pH 4, as in the LANTUS injection solution, it is completely soluble.
I would continue to use insulin glargine, a recombinent insulin analogue (Lantus) without concern. This was the recommendation in the British Journal Lancet Vol 1, 374 issue 9649 p511-513 15 August 2009. The media has produced some fear based upon five studies that I have read, and used some statistical manipulation that would have failed me in "statistics one" in the eighth grade. The experimental protocols were pretty crummy.
Examples are insulin zinc suspension, protamine zinc insulin, and the insulin analogues insulin glargine and insulin detemir. The latter two insulins are now the most widely used long-acting insulins.
* Biphasic insulins: mixtures of short-acting and intermediate-acting insulins in different proportions, such as 30/70, 50/50. Examples are NovoMix 30, Humulin M3, Insuman comb and Humalog Mix25.
When I started using 2u Lantus in morning, 2 weeks ago, I'd go low in the late afternoon/early evening, and then my morning sugars would be elevated ... 140s, 150s. So I split the dose: I'm now using 1.5u Lantus AM & 1u Lantus PM. It definitely works better than 2u QD, and I've checked the middle of the night - not a problem. The drug sheet for Lantus doesn't mention BID dosing, but my internet articles do. What are your thoughts, and is Levemir better for BID dosing?
I have a diabetic cat, "Lickety Split", that is on 5 units 2X/day of Lantus. He has been urinating all over our home for the past two years. Despite the exhausting amount of methods I have read or been advised to do, the inappropriate elimination has continued and we have had to tear up carpets, throw out items, constant every day cleaning soiled areas.... Two years ago, I had questioned whether it might be diabetes because of s/s he was displaying.
The doctor thinks it is too high and gave Recombinant Insulin Glargine Injection and my mother does 15 unit injection every night. But blood sugar is still like 7.3~8.3 mmol/L before meal and 9-10 mmol/L after meal.
Is this often to see among diabetes type 2 patients?
Can some one give me any advice about how to improve my mother's condition?
Sincerely thanks.
A potential disadvantage to Lantus is that it CANNOT be mixed in a syringe with short acting insulin. This characteristic requires taht folks take more shots usually. If the results are good and if you can afford the additional syringes, it is often a good treatment plan.
Good luck & let us know how you're doing...
Your veterinarian will help you with a game plan for regulating her diabetes. Some cats need insulin, others can do just as well on special diets. Many veterinarians are now recommending trying to keep the cat on a grain free canned diet, but not all cats are accepting of that type of food.
Beyond the information you might get here, I would recommend asking questions in our Ask the Vet expert forums here on MedHelp. Another good resource is caninediabetes.org.
Another question from me:P, i have been reading around latley, and have found many differnt types of insulin,and insulin pumpsm etc. all with there pro's,and cons. If possible, could someone please explain to me the differnt types of insulin, and ways of managing diabeties, and the pros and cons of them.
Montefiori Medical Center (Bronx, New York) performed an in-depth study of 240 women receiveing Lantus (insulin glargine) during pregnancy. The results were published in the Journal of Reproductive Medicine, April, 2009 (4) 208-10. They found the drug to be well-tolerated and advised continuing the use of Lantus during pregnancy. PubMed has no studies whatsoever that substantiate an adverse affect on pregnancy.
I have just switched from Mixtard/Actrapid to Lantus/Actrapid 3 days ago due to very poor blood sugar control at night and in the morning. The current dosage of Lantus is 15 units in the morning with additional 15 units of Actrapic before evety meal i.e. breakfast, lunch and dinner.
Blood sugar level in the morning shoots up to 15-16mmol (fasting), by noon it will remain at 9-12mmol (before lunch) and will gradually comes down to 4-5mmol before dinner.
Lantus (insulin Glargine) is a very SLOW release insulin, a so-called "24-hour" insulin. Because it does not rapidly alter glucose levels it is safe to use when driving. It isn't adviseable to increase the dose of Metformin. Other insulins have the tendency to rapidly (comparatively) alter levels of conscious and situational awareness. It is often prescribed together with Metformin and Glipozide. I would also hazard a guess that weight control is an issue.
yes please do check out that very informative site....this Dr. Pierson gives really indepth info also instructions on how to do home blood glucose monitoring...anyone with a diabetic cat needs this as their bible:))
Pip....I just re-read Dr. Piersons site...and she has it written right there that a low carb diet has reduced or eliminated the need for insulin...I will copy some of the studies she has quotes...great job papa cat!!!
I have a cat who was previously diagnosed as diabetic and was on various doses of insulin for about 18 months. About 2 years ago insulin was stopped and the cat is well and healthy. I still give him Hills M/D food partly as a precaution and because he strangely won't eat anything else. He won't even eat fish or meat! I understand that it is possible for cats to become non-diabetic (A phenomenon unique to cats)
Anyway my question is how likely is my cat to develop cataracts?
It is my understanding that if a type 1 diabetic has High BG and ketones, they can go into ketoacidosis and if not treated, they can die, however, I do not believe this would happen in a few hours unless the person was not giving insulin all day long OR unless the person had high ketones all day and could not get his BG down, but I still think that unless the BG was over 600 and not registering on the glucometer, that ketoacidosis would not happen in a couple of hours.
The pen does allow drawing air to insure the Lantis is not injected into a vessel. It should NEVER be used without this precaution. i.e. A PEN IS UNSAFE WITH THIS INSULIN!
B.T.W. I no longer trust or take Lantis, as it relies on forming crystals under the skin to prevent immediate release of the entire dose, and I consider it dangerous for regular use.
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