I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
i was diagnosed with cml in march of 2009 and was also taking 150mg of elavil at bedtime to control migraines for like 10 years. then this past dec. a heart test showed i had prolonged qt of the heart so i was stopped 'cold turkey' by a dr and its been down hill ever since. i have had the shakes, loss of appetite and constant nausea. i wake up evey morning shaky really bad.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great.
I hope this helps you. I would be glad to help you with any other questions.
There is no genetic basis for the CML therefore she was not put on Gleevec. She is on Hydrea to keep the wbc count down to a more normal level. I think the only thing that led to the CML diagnosis was the extremely high wbc with no sign of infection or other cancer. Mayo did the same blood tests as the hometown doctor, as well as the lab in Iowa City. I would like them to run other tests but havent a clue what to ask for.
* buprenorphine Metabolized into norbuprenorphine by cytochrome-P450 isoenzyme 3A4
* Tyrosine kinase inhibitors, including Gleevec and Tasigna, used to treat chronic myelogenous leukemia and gastrointestinal tumors.
Meanwhile, in mice that were prone to develop neurofibromas, the cancer drug Gleevec — an inhibitor of c-kit — reduced the metabolic activity and size of the tumors.
Because Gleevec is already prescribed for chronic myelogenous leukemia and other cancers, the researchers were able to secure fast regulatory approval for a phase 2 clinical trial of the drug in children and adults with neurofibromatosis type 1.
term=cmml
I see different drugs in the pipeline, including Gleevec which is very successful in other blood cancers. I do see some monoclonal antibodies there. Aha, the bortezomib study is here:
http://clinicaltrials.gov/ct2/show/NCT00437086
But it was just a pilot, i.e., the very earliest stage of investigation. But that apparently showed it to be safe, as expected. IOW, it is not a risky last-chance drug. Neither most likely are none the MABs risky, they are very mild in side effects.
my father having hernia problem, he had heart blockages too 90,99,90% we come to know in an geography, we don't want to do bypass sugary but want to do hernia operation whether it is suitable for him???
What does it mean when you are randomly walking around or sitting even when your heart feels like it skips a beat and then tightens up intensely, not allowing any sort of semi-deep to deep breath, but rather only short choppy inhales at a time? It goes away in a range from 25 seconds up to a whole minute. It my variate each time. Any answers to this or experience, maybe to prevent it?
Thank you!
I don't think anyone can really answer this because obviously there is no 'normal' life. Normal to one person could be sitting on a stool all day playing guitar, while to someone else it could mean to do daily gardening or even playing golf. Normal for one person could be driving a truck while to another it could be riding a bicycle. I suppose normal could mean exist, but to exist you could just be laying in bed every day. So normal to each individual has different expectations.
I had SVT (Supraventricular tachycardia) which is a fast heart rate. It makes you feel out of breath, like you might pass out, and like your running a marathon. I had it since I was a child and finally had heart ablation surgery to fix it. They do have meds that help control it. Usually beta blockers (blood pressure meds). I still have heart palps which feel like your heart is skipping beats but they are common and they tell me harmless.
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