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The last thing anybody would want is to stop the Gleevec, which is a wonder drug of anti-cancer treatment. So we must think of "managing" the hyponatremia problem.
I haven't found anything about long term use of Gleevec. But what springs to mind is that she might have started some other drug recently, which is turning mild hyponatremia to severe hyponatremia. Even ibuprofen. Has she?
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
This week I was given the bad news that I had Esophageal Cancer, squamous cell carcinoma. I am 54 year old male that was a pack a day smoker for almost 40 years. It started a couple of months ago. I couldn't swallow anything, I would try and dislodge food that was stuck down my throat with water. But this would work and sometimes not. It's more of a discomfort than pain. I got myself to the emergency at the Civic Hospital in Ottawa.
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
I am sorry to know about your husband’s health. Esophageal cancer is a very aggressive cancer. Treatment of stage 4 esophageal cancer usually includes chemotherapy, radiation therapy and surgical removal of the affected part of the esophagus. Unfortunately, once it has spread, especially to places like the liver, long-term survival is difficult. Cytotoxic chemotherapy is the most effective treatment modality for patients with metastatic disease.
My mom has been diagnosed with stage 3 esophageal cancer. The cancer has spread to the lymph nodes but not to other organs. She is 91 years old. My question is twofold. They recomend radiation therapy. Will this help to improve her quality of life and perhaps extend her life, and I would like to know realistically what her life expectancy is with this diagnosis.
This discussion is related to <a href='/posts/show/883905'>esophageal cancer life expectancy</a>.
It seems that when I look up symptoms for esophageal cancer, hiatal hernia, and GERD, that they all have the same symptoms with the exception of bleeding (which is late in the cancer stages). Knowing that I have a hiatal hernia and GERD, how might I get a clue from symptoms if I were developing esophageal cancer without getting a regular endoscope?
You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great.
I hope this helps you. I would be glad to help you with any other questions.
D Doctor presented to my father the diagnosis of esophageal cancer. My father was admitted and was seen by gen Surgeon in the a.m. Gen Surgeon the did a Endoscopy with biopsy of 2 diff areas of the mass both of which were neg for cancer. Peg tube was placed for later chemo indwelling cath was placed and cone chest tube was placed for drainage of fluid due to according to surgeon of the tumor causing irritation of the pleural sac.
I have been living with GERD since birth for sixteen years, i have been in and out of the hospital and had more tests done to me then you can imagine. Most of my summers have been in Driscol's Children Hospital in Corpus Christi Tx. I am on a strict diet, not eating anything spicy or late at night. I don't eat anything with dairy since i'm lactose intolerant, i am allergic to almost everything edible and my dad is diabetic so my mothet and i eat practically his diet.
Personally I think he should have a gastroscopy to make sure that he doesn't have an Esophageal problem and they will also check the different sphincters to see if they are working properly. It wouldn't hurt to have an allergy check but if he hasn't had a gastro and he is over 50 then I would have it checked as well as have a colonoscopy.
The phlegm could be from the banana so stop getting bananas for awhile and see if that helps.
Complete eradication was achieved in 77% of 48 patients, with a 10% rate of major complications including hemorrhage, esophageal stricture, and esophageal perforation. Although these observations indicate that high-power APC can eradicate Barrett's epithelium in some patients, it is not clear that this expensive and hazardous therapy conveys any clinical benefit.
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