possibly increasing the risk of a
bleeding complication (e.g., gastrointestinal
bleeding, ecchymoses, epistaxis, hematomas, petechiae, hemorrhage)
Celebrex and Metoprolol:
Celebrex may decrease the effectiveness of Metoprolol, and lead to an elevation in blood pressure (approximately 5 mm Hg) when given over a period of weeks. This effect is most significant in patients receiving concurrent antihypertensive agents and long-term Celebrex use.