Just diagnosed with a 43% ejection fraction and my doctor prescribed Avapro. Is this the proper treatment?? He gave me samples of 150 mg tablets and said I could cut them in half and just take a half a pill once a day. What do you think about that?
Discontinuation of Dosing
Patients with inadequate viral response are unlikely to achieve SVR, and may develop treatment-emergent resistance substitutions [see Microbiology (12.4)].
12.4 Microbiology
Persistence of Resistance-Associated Substitutions
Persistence of telaprevir-resistant NS3 amino acid substitutions has been observed following treatment failure.
The reason is that only one nucleotide substitution is needed relative to the subtype 1a sequence to generate this variant, whereas two substitutions are needed relative to the 1b sequence (codon usage bias). Overall, natural polymorphisms at positions R155 and V36 are frequent in subtype 1a, but rare in subtype 1b where substitutions at position A156 are preferentially selected in vitro [19].
The medication prescribed to me is Avapro HCT 150mg/12.5mg (Irbesartan and hydrochlorothiazide) taken once daily (1 tablet) mainly to help ensure the blood pressure remains under 140 systolic, which is believed to help reduce the pressure on the aorta and root. I am booked in for a second opinion with another cardiologist next week mainly to re-assure myself and my wife (and kids) that things are chugging along okay.
[54] In pooled analyses of subjects who had on-treatment failure or relapse during clinical trials with boceprevir or telaprevir, HCV variants emerged, which have been shown to carry several NS3 amino acid substitutions that reduce viral susceptibility to boceprevir and telaprevir (Table 10).[51,53] Extensive cross-resistance exists between the 2 drugs, one of several reasons why they should never be used together.
Tks Jon, but I finally could set a meds supply line from US down here, so, no substitutions will be needed, by the time being.
I had FET on Saturday, May 21st. This 2ww wait is killing me. Trying so hard not to test!!! At least to check if my trigger shot is our of my system. I haven't had any caffeine since my transfer. I am really needing a decaf coffee! One cup wouldn't hurt? Anyone have good substitutions?
Broke through Verapamil now on Atenolol and dose has been raised.. recently have high blood pressure and now want to add avapro to the regieme.... any answers? 45 year old woman with child 9 yrs old.
Second, when compared to a consequence sequence of 35 treatment-naïve patients with HCV genotype 1b, R130K and Q195K substitutions were unique to the present case.
Hx: Hubby 47 has had HBP for 1 year? systolic(136-150) dyastoic(104 118). Heart rate high 90's or 100 - 110. Took Avapro o/d x 1 month July/08. Stress test after second appt. was okay. Cholesterol ok. BP still up. ie: dyastolic 108 - 118. Ht rate 100 - 120. Hubbies father has MI at age 51 died. Hubbies bro at 49 had a massage coronary and died. (2002). Family doc doesn't seem concerned.
I think his heart rate is too high. His dyastolic pressure is still high.
Im like that!
You have to find substitutions for the problem foods that start your appetite off. No sugary drinks at all. Change to water or tea without sugar or use agave nectar. Fruit is your new sweet. Try veggies for breakfast. Change it up!
I had been taking 150 mg of avapro for 10 years for high blood pressure. I recently lost 25 pounds and was able to maintain my blood pressure on 75 mg. in fact with a home machine my blood pressure is consistently low. It never goes above 106/70 and most often is 90-97/70-75. Would it be safe to stop taking the medication to see if I can keep the pressure from getting high? Or would it be safer to cut the pill in half and if so, for how long?
Rash is mainly on left eye and one spot on cheek, small rash on right eye. I do sleep on left side. Other med is Avapro for HBP and I have been on that for 2 years. Thank you!
I take avapro for blood pressure, immovane for sleep and now to quell the anxiety. I have frequent ophthalmic migraines (all sparkly lights, no pain) and have a pain migraine every two weeks or so. I can't get anyone to help me and with every week I am that much less functioning. Oh, I've also gained 40 lbs in six months; mostly belly fat. Please!! Any thoughts? Suggestions? Home remedies while I wait to get a doc to take me seriously?
We are not physicians nor pharmacists and you should consult one or both about drug substitutions and dosage equivalents.
One day I ate some white rice, sugar suddenly fall to 8 mmol, then even a tiny piece of roti was dropping suddenly. Blood pressure increased, Took avapro, started eating more protein. But I did not get any medical support. Family doctor says, I do not know, hospital says go to family doctor. Family doctor did not give any specialist. However after 5 months, sugar settled between 8 mmol to 11 mmol without medicine. But I was eating less carb, mostly vegetable and rotein.
t worry about counting calories or anything complicated. Just make substitutions. Drink water instead of anything else. Eat a baked sweet potato with the skin instead of mashed potatoes. Eat brown rice instead of white rice. Eat multi-grain bread instead of whole wheat or white bread. Fruit instead of ice cream. Each of these substitutions will do two things: you will feel more full with less food and your blood sugar levels will improve.
A year ago, my doctor gave me Lescol/Fluvastatin to take because I am a high risk for heart disease due to genetics and diabetes. At that time my Lipids were within normal range. After a month, ALT/AST results were very elevated.
and medication was discontinued. Since then, I've gone through ultrasound, HiDa Scan and finally diagnose of fatty liver. The Gastroenterologist recommended Liver Biopsy to check for liver damage.
m on BP medication (avapro 150mg). My BP is usually in check running around 118/70. No family history of heart disease (except Dad passed away from cardiomyapthy, was determined to be a non-genetic virus that attacked his heart).
I'm 30 years old, 5'11 195 lbs. I try to eat pretty healthy, lots of fruits and veggies. Exercise a few times a week. I've had the following tests done.
Suggest either not giving dairy products before bed and if that does not work, then change to milk substitutions for calcium. The substitutes for dairy products are soymilk, rice milk, almond milk, soy cheese, soy yogurt, soy ice cream, and rice ice cream. Hoped that helped you.
So it is not like you did 48 weeks of treatment and failed. So the amount of viral resistance substitutions should not be too great. What was your viral load at week 4? So it is a good thing that you stopped treatment early.
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"2.
5 log copies / mL. At the start of combination therapy, amino acid substitutions of the reverse transcriptase (rt) gene, rtL180M, rtT184I / M, and rtM204V, were detected. After this, serum HBV DNA decreased to less than 2.1 log copies / mL and remained at this level until 31 months of combination therapy, when it again began to increase. Amino acid substitutions of rtL180M, rtS202G, and rtM204V emerged and were associated with an increase in serum HBV DNA at virologic breakthrough.
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