ribavirin pi

The addition of boceprevir to peginterferon/ribavirin is associated with more anemia than is seen with peginterferon and ribavirin alone.[Boceprevir PI] This can be managed with ribavirin dose reduction and, if required, erythropoietin, with no apparent loss in treatment efficacy. The additional decrease in hemoglobin seen with use of boceprevir is approximately 1 g/mL over that seen with peginterferon and ribavirin alone. Anemia resolves with discontinuation of boceprevir.

I am just stressing that it is very important to take our PI exactly on time, to avoid developing a resistance.

Whether you agree or not with pre-dosing, the fact that the PI's work together with interferon and ribavirin is not "old school". Dosage reductions earlier than later with interferon/ribavirin in PI triple therapy result in somewhat lower SVR rates. So clearly the effectiveness of inteferon/ribavirin matters in conjunction with a PI or else it would be PI monotherapy and it's not.

Now my (new) doctor is going to treat me with PI and wants to only give me 800 mg of ribavirin a day (I will be taking pegasys and incivek). The new doctor said I get 800 mg of riba because I weigh 115 lbs, but that was what I weighed in 2008 when I was prescribed the 1000 mg of riba per day. New doctor mentioned I will get Riba-Pack which I did not have the last time. I have some ribavirin left over….

Peg and riba are still absolutely necessary and neither therapy is successful without them because the peg/riba can still knock out the protease-resistant variants that arise. There is another PI, ITMN-191, that attacks the same protease (NS3/4A), but causes a mutation in a different place than those seen with teleprevir and boceprevir. That will be the one to watch for those who were unable to succeed with teleprevir or boceprevir. Looking forward to what happens next.

Maybe one day they will use the PI as maintenance for the ones who dont respond to SOC and PI drugs.Ive heard of aids people liiving a lot longer now because of the PI`s too.Some are with aids for 25 years and still doing ok. "An apple a day keeps the doctor away, But if the doctor is cute forget the fruit.

Speaking for myself my tx of choice will be triple therapy which will consist of interferon, ribavirin and a protease inhibitor. The PI is expected to be released sometime in 2011. I am a genotype 1 with advanced liver disease, however, the odds of achieving SVR with a PI added to the mix for geno 1's go from a little below 50 percent to a little above 70 percent. With numbers like that is makes sense to wait even with advanced fibrosis.

I'm so depressed at this point that it's hard to make it worse [grin]. Re TMC435, if you are referring to trial NCT00882908, I looked it over and was put off. There are so many arms, many without the PI (or with partial PI), that I didn't like it. Plus it's only a Phase II trial, and the results of previous trials are not in yet, I don't t think. Also, Argentina is not listed as a trial site, and I wouldn't go back to the States for this trial.

I was thinking about this recently. If somebody try's a PI, and fails / builds resistance to that PI, then re-infects somebody else in the general population with Hep C - won't the disease gain resistance to that PI? The new mutation could spread, and become the standard for Hep C (given the new resistance, will make it live longer). Are PI's a short term fix, that the virus will eventaully become resistant to?

Are there any relapse studies yet i wonder for the PI trials,i know its like 95%-99%(SVR) with the SOC drugs between weeks 4 and 24,BUT...

First two I was 17 (tx for 2 months) and 18 (tx for 6 months) and was not taking ribavirin like i should have. I have been on 180mg pegasys and 1000 ribavirin for the past 22 weeks and it has been very rough. Headaches and fatigue constantly. I really want to get rid of this virus. I know I need to extend 72 weeks. My dr says my chances are 0% but he'll let me continue. But are my chances so low it's not worth it.

This is a third drug added to the combo treatment of Peginterferon and Ribavirin. These PI drugs significantly heighten the chance of successful treatment and aim at cutting the time of treatment to 24 weeks.

my treatment is a bit different as i have 2 riba per day of 400 ea and my shot of pi is 180 but i have had no side effects to speak of yet and i just took my 19th pill (day 8) so if that gives you any relief...to me the anxiety was lots worse than the reality.

Genome-wide association studies have identified a single nucleotide polymorphism (SNP) (rs12979860) upstream of the IL28B gene, which is associated with higher sustained viral response rates to pegylated interferon/ribavirin therapy in HCV genotype 1-infected individuals.

my dr just thinks my immune system is kicking butt LOL im almost 50 have had this for 30+ years, im def going to be treating soon ... my dr is concerned about the extra toxicity with the PI and he doesnt want to give it to me if i dont need it, but i want it just to make sure i get rid of this... his plan is to wait another few months and see how the PI is working for others and then make a decision.... im just wondering if anyone else has had drastic drops in viral load without treating...??

I know what PI means, but what are regular treatments for HepC? I have already done the ribivarin/interferon treatment. It knocked the virus down, but it came back within a month. Thanks!

Patients who have undetectable HCV RNA by Week 4 of therapy, whether with protease inhibitor (PI)–based triple therapy or with peginterferon/ribavirin alone, are very likely to achieve sustained virologic response (SVR). By contrast, those who still have detectable HCV RNA levels by Week 12 of therapy have very low likelihood of obtaining SVR.

the doc said that compensated cirrhotics treating with the PIs can look forward to receiving 48 weeks of peg and ribaviron along with the PI. even if you experience an undetectable viral load at 4 weeks they will try to dose cirrhotics for 48 weeks.

I am planning to do triple tx with ribavirin, pegasys, and incivek. My liver doctor will treat me with triple tx but only wants me to take 800 mg of riba daily based on my weight which is 115 lbs. Out of curiosity, today I called my GI who also treats for Hep C and he also said my daily riba dose would be 800 mg because of my weight. Both doctors stated that the 800 mg dosage it is strictly because of my weight and no other reason.

t give her the RIBA in addition to the IFN and PI. IDIOTS of all of the people to do that too! She almost got to UND for like the first time with it but......without the riba it did not work. Now she cannot take another PI. Trying to say make SURE you are getting all 3 or seriously reconsider...lI'm pretty sure that was what she took I'll see if I can flag her in an email and see if she can post!

My personal take on this is that we don't get resistant against interferon and ribavirin. These drugs are not directly aimed at the virus. Interferon increases our immune response, and what ribavirin does we really don't know. The protease inhibitors are however directly aimed at the virus, so we get resistant to them. That is why non-responders need to think very carefully before retreating with PIs. They might need to add more than a PI to the mix in a future tx.

I would like to get any information from anyone that has had a liver transplant that is now taking the 3 drug treatment with Ribavirin, Incevic and Peginterferon, to combat the Hep C. Thank you!

High Ribavirin? I am thinking about trying tx in a clinical trial with high riba. (about two times normal). It seems like a lot of people here who did clear with SOC had more side effects than those who did not clear. I had few side effects but also did not clear. Maybe its the riba I thought jmjm530 cleared using lots of Riba? Anyone else do this or have thoughts?

SCH 900518, when added to the current standard of care (SOC), peginterferon-alfa plus ribavirin, would likely increase the proportion of patients achieving undetectable HCV-RNA levels and sustained virologic response (SVR). In this study, SCH 900518 would be used in combination with low doses of ritonavir to enhance the levels of SCH 900518 within the body and reduce the number of daily SCH 900518 tablets required.

Common Questions and Answers about Ribavirin pi

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