[5]
Women with PCOS who are insulin resistant are at high risk for the development of diabetes
in pregnancy, and a possible role for metformin therapy may be the prevention of
GDM.
In a cohort of 33 women with PCOS taking metformin until delivery, GDM occurred in 3% compared with 23% in 39 women taking no medication.[4,6] However, given the lack of data from well-designed, prospective clinical trials, metformin is currently not indicated for the prevention of GDM.