Zofran is better during pregnancy, I don't like promethazine as much because it has some bad long term side effects, and zofran is more effective. They use it for chemo patients. Let's be clear about form of promethazine as it comes in a liquid mainly for cough medicine promethazine w/codeine (promethazine w/codeine syrup is highly abused in our country) plain promethazine syrp, promethazine vc syrp and pill form.