Doctors historically have not treated this group because there appeared to be no sign of liver damage. However, doctors now know that high viral loads may increase patients’ risk of liver damage and cancer as they age, despite their normal ALT levels.
Most participants in the study were Asian and the average age was 33. Nearly all were HBeAg-positive and had HBV DNA levels at around 10 million IU/mL.
I have discussed with my doctor to start the anti-virus treatment immediately to reduce my liver damage. Since I have been treated with Lamivudine in 2000 for 11 months, which was totally not effective (HBV-DNA did not decrease). But, at that time, my ALT was 40. I should not given this drug considering my immune tolerant state! However, I probably can not blame my doctor too much if it dates back ten years ago. But, this failed treatment may induce LAM-resistance in my body.
yes you are right, etv will work but for a short time (about 50-70% resistance at 5 years), very bad solution
i suggest check hbvdna with ultrasensitive hbvdna and see if it increases, decreases again because truvada resistance is very unlikly although not impossible
you can check with this supersensitive assay
http://www.ngi.com/
http://www.ngi.com/downloads/hbv_ultraqual.
by the waythe first thing you have to do is check why the use of truvada since it has kidneys toxicity, tenofovir monotherapy is much more indicated or if you have to combo for a very fast effect tenofovir plus lamivudine or tenofovir plus entecavir
also be aware these antivirals have no effect on hbv or infected cells in the liver, they only lower hbv replication so that there is no liver damage and in your spesific case they allow immune system suppression without the risk of liver failure du
I have read articles which said AZT based PEP causes liver damage, nerve damage, mitochondrial toxicity, DNA damage, and an inflammatory immune syndrome called Neuromyotonia.
I have taken Lopinavir&Ritrnonavir & Truvada. are these also AZT? or equally harmful.
I have also read someone saying no documented case of anyone who has lived for more than 15 years after taking PEP
I'm 24 years old sir, I want to know my possible future side effects sir.
I had high VL, twice the normal ALT with no liver damage at the time six years ago. And he gave me ETV. Well aware of what he was doing. Then telling me a year later that interferon was my best option. And then he totally dumped me because my insurance did not pay their office enough. and enough for these guys if they get $400-500 for a visit. And this guy does research and is published also. "the so called good doctor" that is.
check hepatitstechnologies products, todd had cirhosis due to hbv+hcv and reversed cirrhosis totally from 2004 to now, so whatever happens you can block all liver damage especially if your liver has much less damage than cirrhosis
make sure you have acess to a fibroscan because this is the only tool to monitor liver damage.
I'm taking Truvada now for almost 2 years (Undetectable HBV DNA, e antigen still positive, lam resistance).
Can I switch to Baraclude? It will be easier for my budget since it cost way less coz' I'm planning on moving back home. I'm in the US.
Any possible resistance or virus breakthrough if I decided to switch therapy?
When people with hepatitis B stop taking tenofovir – or if HBV develops resistance to it – this can cause the virus to reactivate, potentially leading to flares of increased liver inflammation and worsening liver injury, typically signalled by steep increases in ALT and AST liver enzyme or transaminase levels. The risk of hepatitis flares is higher for people who already have liver cirrhosis.
Do you recommend the truvada over the viread or baraclude? If while being switched from Hepsera to truvada is there a risk that the Hep B could become active? Also , the Hepatitis B DNA is currently undetectable and the Hep B Surface AG is currently negative (both prior to transplant as well as post transplant, so far ) what are the chances that the Hep B could become active again once the Hbig infusions are stopped? Thank you.
After doing some reading, I see that Truvada+Kaletra (or Truvada alone) is a commonly prescribed PeP regimine. I know that Truvada is part of the Stribild combo, but Im not sure why this was the specialists choice? I saw that there is an ongoing clinical trial with regards to Stribild as PeP, which would mean that it is not yet approved for such purposes?
My questions for you are: Will Stribild even be an effective PeP treatment?
Hello All,
I was diagnosed for Hep-B around 2 months back and following is my liver biopsy report, and also my other blood test report. My doctor said this is MILD-to-MODERATE right now and we can wait for one year before we start with medication (he said I can take Tenofovir and he also said there is some other tablet which is combination of tenofovir and something else (that Idont remember)).
the virus and the illness hepatitis are two different things, virus replication damages the liver and makes liver cancer/cirrhosis, entecavir can only block replication and liver damage so that you won t dye of cirrhosis or liver cancer but cannot eradicate hbv in the majority of patients, about 19% have hbsag lowering and will eradicate virus but therapy must be continuous for many years until hbsag gets negative
since your hbeag has got negative in one month already you might have more chance
my sister was recently diagnosed for hepatitis B,her test results were as follows:HBEag :NEGATIVE, HBEab :POSITIVE, PCR HEP B QUANT :2014cps/ml. The liver biopsy result says 'section shows liver tissue showing plate of hepatocytes between central vein and portal tracks.There is periportal lymphocytic infiltrate extending to the middle of the Acinus within the sinuses'.she is not symptomatic.she has been asked by her doctor to start interferon and truvada.
The doctor there refused to do so because he claims these drugs could damage liver and must be used within 5 hours to be effective. Can one 30 day treatment damage liver? He claimed I would need a whole bunch of lab work for him to even consider giving me prescription (check my liver and STD status, which he claimed are required by his company, Concentra).
Does this make sense? Reason I asked is this seem to contradict what I heard before.
Many Thanks.
thats just made to please insurance companies, infact you can t measure effectivness of this potent combo with hbvdna in the blood because it gets to und, to measure difference you need to measure hbvdna in the liver because it never gets to und in the liver
anyway those with very high hbvdna, where etv mono is not potent enough to make hbvdna und, did have a difference and also hbsag serocoversions were higher on combo
that s just a advertisemnt website, look for the poster here in the commun
when I experienced high alt, over 200 at one time, while taking truvada my dr was also very concerned if any damage to liver, then switched me back to viread, and alt was still consistently 80 to over hundred. (I was taking lamivudine, hepsera initially around 2004 and was told the hbv mutated only in a few months, then switched to viread, and the virus was quickly under control in a few months, the dr.
Congratulation Bm2016! For how long u were at this clinical trial ?
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