When people with hepatitis B stop taking tenofovir – or if HBV develops resistance to it – this can cause the virus to reactivate, potentially leading to flares of increased liver inflammation and worsening liver injury, typically signalled by steep increases in ALT and AST liver enzyme or transaminase levels. The risk of hepatitis flares is higher for people who already have liver cirrhosis.
Doctors historically have not treated this group because there appeared to be no sign of liver damage. However, doctors now know that high viral loads may increase patients’ risk of liver damage and cancer as they age, despite their normal ALT levels.
Most participants in the study were Asian and the average age was 33. Nearly all were HBeAg-positive and had HBV DNA levels at around 10 million IU/mL.
yes you are right, etv will work but for a short time (about 50-70% resistance at 5 years), very bad solution
i suggest check hbvdna with ultrasensitive hbvdna and see if it increases, decreases again because truvada resistance is very unlikly although not impossible
you can check with this supersensitive assay
http://www.ngi.com/
http://www.ngi.com/downloads/hbv_ultraqual.
I have discussed with my doctor to start the anti-virus treatment immediately to reduce my liver damage. Since I have been treated with Lamivudine in 2000 for 11 months, which was totally not effective (HBV-DNA did not decrease). But, at that time, my ALT was 40. I should not given this drug considering my immune tolerant state! However, I probably can not blame my doctor too much if it dates back ten years ago. But, this failed treatment may induce LAM-resistance in my body.
I'll start 1st by saying I'm a gay male who sought out Truvada as PrEp as a way to further eliminating my risk of HIV. Late October 2015 I sought out an infectious disease Dr who was knowledgeable of Truvada as Prep. Prior to him giving a prescription I was required to have a full blood panel along with a HIV test also screened for Hepatitis. This is when I discovered I was Infected with Chronic HBV. I had elevated alt & ast as well as a viral load in the millions.
has anyone been prescribed Truvada? If so I would like to know how you are doing with it? and if it is helping your hepatitis b? I have stage 4 kidney disease. My hepitologist just prescribed this med. My labs were not good. He hopes to get the virus under control so I can possibly get a kidney transplant. This would be a kidney from a cadaver donator, someone who had hepatitis b. So I am about to begin my journey.
Do you recommend the truvada over the viread or baraclude? If while being switched from Hepsera to truvada is there a risk that the Hep B could become active? Also , the Hepatitis B DNA is currently undetectable and the Hep B Surface AG is currently negative (both prior to transplant as well as post transplant, so far ) what are the chances that the Hep B could become active again once the Hbig infusions are stopped? Thank you.
Hello All,
I was diagnosed for Hep-B around 2 months back and following is my liver biopsy report, and also my other blood test report. My doctor said this is MILD-to-MODERATE right now and we can wait for one year before we start with medication (he said I can take Tenofovir and he also said there is some other tablet which is combination of tenofovir and something else (that Idont remember)).
I read somewhere that there are reports out there that Truvada along can clear hbsag at around 10% per year. Which is if true makes it the best antiviral option for us from what is available.
Lets share ideas on this.
The way I see it it is a powerful combo for hbv. 200mg of tdf and 200 emtricitabine.
I'm taking Truvada now for almost 2 years (Undetectable HBV DNA, e antigen still positive, lam resistance).
Can I switch to Baraclude? It will be easier for my budget since it cost way less coz' I'm planning on moving back home. I'm in the US.
Any possible resistance or virus breakthrough if I decided to switch therapy?
thats just made to please insurance companies, infact you can t measure effectivness of this potent combo with hbvdna in the blood because it gets to und, to measure difference you need to measure hbvdna in the liver because it never gets to und in the liver
anyway those with very high hbvdna, where etv mono is not potent enough to make hbvdna und, did have a difference and also hbsag serocoversions were higher on combo
that s just a advertisemnt website, look for the poster here in the commun
Dr Sean
Sir,I had a unprotected sex with a sex worker due to condom break, i found it after sex over. Its almost 35 days ago. Just after exposure, i started Truvada once a day after approx. 6 hrs from exposure. On next i tracked sex worker for testing elisa hiv thats come back negetive. I completed 28 course of truvada. LFT,KFT are normal that done after 32 days of exposure, but CBC having high lavel lymphocytes 49.3% and low Eosinophils .90%.
check hepatitstechnologies products, todd had cirhosis due to hbv+hcv and reversed cirrhosis totally from 2004 to now, so whatever happens you can block all liver damage especially if your liver has much less damage than cirrhosis
make sure you have acess to a fibroscan because this is the only tool to monitor liver damage.
After doing some reading, I see that Truvada+Kaletra (or Truvada alone) is a commonly prescribed PeP regimine. I know that Truvada is part of the Stribild combo, but Im not sure why this was the specialists choice? I saw that there is an ongoing clinical trial with regards to Stribild as PeP, which would mean that it is not yet approved for such purposes?
My questions for you are: Will Stribild even be an effective PeP treatment?
I am looking to speak with anyone taking the med combo of Norvir, Truvada, and Reyetaz. Wondering if anyone has noted side affects of these drugs....
If you are producing too much cholesterol with a carefully controlled diet, then you may have a hyperactive Liver. I have hypercholesterolemia, which basically means when I sleep, my Liver turns my blood into fat soup. Only around 20% of the fat in your blood comes from food, the Liver can make fat by itself and does. Without statins my total cholesterol is 375-400. With 40mg of Atorvastatin accompanied by Ezetimibe, It is 160-162.
my sister was recently diagnosed for hepatitis B,her test results were as follows:HBEag :NEGATIVE, HBEab :POSITIVE, PCR HEP B QUANT :2014cps/ml. The liver biopsy result says 'section shows liver tissue showing plate of hepatocytes between central vein and portal tracks.There is periportal lymphocytic infiltrate extending to the middle of the Acinus within the sinuses'.she is not symptomatic.she has been asked by her doctor to start interferon and truvada.
Yesterday, I took 1 Truvada at 7am but since I was in a hurry after dinner, I accidentally took one more Truvada last night. I tried to vomit it up but I was able to vomit only a part (dissolved part) of it. Because of panic, I forgot to take Kaletra last night. I rushed to the A&E and asked the doctor's advice on what to do. Since I waited for more than 3 hours before I was able to see the doctor, I was already drowsy when the doctor talked to me.
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