“If you are unaware that a patient is on simvastatin and you give either boceprevir or telaprevir, the simvastatin level in the blood can go high and patients can develop muscle breakdown,” said Dr. Jensen.
http://www.idse.net//ViewArticle.aspx?
The dose can be increased to 80mg if necessary. cpk is an emzyme found in both skeletal muscle and cardiac muscle. If it was normal then u do not have rhabdomylosis, which is the side effect of simvastatin which your doctor was looking for. He has done the correct test and the result was negative. Return to doctor for further investigation of these muscle aches.
The level of creatine phosphokinase enzyme should be checked. If this is raised then there is muscle injury and the drugs should b stopped. If CPK is normal, then the dose and exercise adjustment should help. Fat-soluble statins like Lipitor and Zocor cause more damage than water soluble statins like Pravachol and Crestor. Hence the latter should be tried at lower dose.
hi just wanted to add that it sounds like part of the problem is the staten. The muscle problem and weakness. The ange and lack of interest is something else I think and maybe he is depressed? Does he have a reason to be depressed? Also, maybe check his thyroid while you are at the doctor. Tiredness and irritablility could be that. Is he sleeping too much or not enough?
Hope you can shed some light on this but I would tell the doctor all his symptoms and don't feel like they are nothing.
I have been on 20 mg of simvastatin and 3000 mg niaspan now my ck levels have went from 60 to 295 i could hardly walk .will my levels come down if i lower dose. and reverse damage. i have 12 stents .the rest of my blood work is fine.
Research shows that 61 out of every 1000 patients on 80mg of simvastatin develop muscle problems. I do believe the half life for Simvastatin is quite short, 5 hours or less. If you take 80mg, then 5hours later only 40mg will remain. Another 5 hours only 20mg. So after 24 hours there will only be around 2-3mg in your body which is top up time.
Patients were put on a cholesterol-lowering diet and given one of the medications. After 18 weeks, patients given simvastatin had significantly lower total cholesterol, lower LDL, lower triglycerides, and higher HDL cholesterol levels than those who took pravastatin. The study found that the patients on simvastatin achieved the target LDL level of less than 130, more than those on pravastatin (65 percent on simvastatin versus 35 percent on pravastatin).
I quit taking the simvastatin last tuesday, and by friday I looked perfectly normal with no steroid cream......
Thanks again for all the help!
My endocrinologist prescribed me Atorvastatin 40mg in place of the simvastatin but it has since given my major chest pain and muscle weakness in my fingers and legs; so I was advised by the pharmacist to stop that and I have only taken the new statin twice and tonight was the second time taking it.
Is simvastatin something that can be eased up to a higher dose to do the exact same thing atorvastatin does for the bad cholesterol?
I'm on Simvastatin (40mg) which have some nasty side effects, like cramps and muscle spasms. Can you reommend an alternative?
) For the past 20 years, I have avoided NSAIDs, acetaminophens, other pain relievers and muscle relaxants because of their adverse effects to liver and kidneys (personally more significant because my dad had kidney disease). Since cannabidiol inhibits the liver's production of cytochrome P450, I am wondering about switching from simvastatin to pravastatin. That would allow me to try CBD, which appears to have minimal side-effects.
My 55 year old husband recently volunteered at work for a new heart scan to test the machine. It showed he had a fair amount of calicification in one of his descending arteries. He has alway kept himself extremely fit and runs every other day and lifts weights. His doctor started him on Lipitor 20 mg. After a few months he can hardly move-- his joints ache and he is getting new joint injuries daily-- (knuckels are swelling--arm muscle injury won't heal--)..
Advicor (lovastatin/niacin extended-release), Simcor (simvastatin/niacin extended-release), and Vytorin (simvastatin/ezetimibe).
Hi,
My partner is a 35 yr old male who for the last 2 weeks has been suffering from severe muscle cramps in is right hand and right foot. It starts with a tingling in his right arm from the elbow downwards which then causes his hand to cramp and lock with the fingers clawing in towards his palm. At the same time, his leg starts to burn from the caf down into the foot and goes into a cramp with his toes turning downwards and inwards.
There have been rare postmarketing reports of fatal and non-fatal hepatic failure in patients taking statins, including simvastatin. If serious liver injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs during treatment with Vytorin, promptly interrupt therapy. If an alternate etiology is not found do not restart Vytorin. Note that ALT may emanate from muscle, therefore ALT rising with CK may indicate myopathy [see Warnings and Precautions (5.1)].
x/full
very interesting study which confirms why simvastatin, lowering cholesterol drug and actos (diabetes 2 drug), have anti hbv activity lowering hbvdna, cancer risk, all this without problems of resistance and acting on all hbv mutants
conclusions:
The discovery of the mechanisms by which HBV is controlled by the hepatic metabolic milieu may broaden our understanding of the unique regulation of HBV expression and may also explain the mechanisms by which HBV induces liver pathologies.
Problem is I think if you can't take one statin you may not be able to take any. But there are other drugs you can try like Niaspan (slow release niacin) and vitorin and so forth. I don't know if you are into changing your diet but if you get a chance watch the video Forks over Knives. It is how a plant based diet can reverse althroschlerosis. My husband's cholesterol was 260, blood pressure was 140/90 and weight 260. He is 6' 2" though.
The risk of any side effect is anywhere between 2% and 5% which classifies this as very safe. Common side effects are muscle pain and sore joints. I would take it and just keep an eye out for anything that may be a side effect. This link will tell you what to look for;
http://www.emedicinehealth.com/drug-simvastatin/article_em.
nothing to do with super research, you take simvastatin and then check hbsag, but of course for research you must use better tools but for us even this tool is ok, we just need to see if it lowers it on us
sim is ok for people with very little liver damage like f1-f2 and it is better to check all liver parameters if trying it now because in rare cases there is muscle/liver damage
We have been on simvastatin for (wife for 1+ years, me for 2+ years) and stopped about 5-6 months ago - wife still having pains in the butt some dizziness and leg pain, but getting better - I am having butt pain and leg pains, swollen left knee, (but joint pain seems OK on stairs), recovery seems slower than my wife's. But both of us have just been diagnosed with right enlarged renal cysts which were not there before taking simvastatin.
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