simvastatin and muscle damage

“If you are unaware that a patient is on simvastatin and you give either boceprevir or telaprevir, the simvastatin level in the blood can go high and patients can develop muscle breakdown,” said Dr. Jensen. http://www.idse.net//ViewArticle.aspx?

I have been on 20 mg of simvastatin and 3000 mg niaspan now my ck levels have went from 60 to 295 i could hardly walk .will my levels come down if i lower dose. and reverse damage. i have 12 stents .the rest of my blood work is fine.

Hello all. I'm a 26 year old male and have a cholesterol problem with high tryglycerides. I understand I NEED to be on something but i've stopped taking my simvastatin as the longer i've been on it i'm noticing my arms are becoming pathetically frail , weak and tiny. My wrists seemed to have shrunk to the point of where I can cuff my hand over them to a scary point. At first I thought I had a disease of some kind but tests have shown everything is fine.

Patients were put on a cholesterol-lowering diet and given one of the medications. After 18 weeks, patients given simvastatin had significantly lower total cholesterol, lower LDL, lower triglycerides, and higher HDL cholesterol levels than those who took pravastatin. The study found that the patients on simvastatin achieved the target LDL level of less than 130, more than those on pravastatin (65 percent on simvastatin versus 35 percent on pravastatin).

The dose can be increased to 80mg if necessary. cpk is an emzyme found in both skeletal muscle and cardiac muscle. If it was normal then u do not have rhabdomylosis, which is the side effect of simvastatin which your doctor was looking for. He has done the correct test and the result was negative. Return to doctor for further investigation of these muscle aches.

x/full very interesting study which confirms why simvastatin, lowering cholesterol drug and actos (diabetes 2 drug), have anti hbv activity lowering hbvdna, cancer risk, all this without problems of resistance and acting on all hbv mutants conclusions: The discovery of the mechanisms by which HBV is controlled by the hepatic metabolic milieu may broaden our understanding of the unique regulation of HBV expression and may also explain the mechanisms by which HBV induces liver pathologies.

Can medications to lower high chlorestorol damage your liver, I have non-alcoholic fatty liver disease now and I am afraid to take statin drugs. How important is my concern. Simvastatin is one in particular.

Research shows that 61 out of every 1000 patients on 80mg of simvastatin develop muscle problems. I do believe the half life for Simvastatin is quite short, 5 hours or less. If you take 80mg, then 5hours later only 40mg will remain. Another 5 hours only 20mg. So after 24 hours there will only be around 2-3mg in your body which is top up time.

The FDA requires warnings that statins may increase the risk of liver damage, memory loss and confusion, elevated blood sugar, type 2 diabetes, muscle weakness (for certain statins). Increasing blood sugar levels can lead to weight gain.

My endocrinologist prescribed me Atorvastatin 40mg in place of the simvastatin but it has since given my major chest pain and muscle weakness in my fingers and legs; so I was advised by the pharmacist to stop that and I have only taken the new statin twice and tonight was the second time taking it. Is simvastatin something that can be eased up to a higher dose to do the exact same thing atorvastatin does for the bad cholesterol?

Warnings and Precautions Because simvastatin can affect the liver, it is used with caution in people who drink more than a moderate amount of alcohol or have a history of liver disease. Simvastatin is not recommended for people with liver disease or high liver enzymes before treatment begins. Possible Symptoms of Liver Problems Several symptoms can occur in someone who develops liver problems while taking simvastatin.

in New Zealand), which my GP had prescribed me 2 years beforehand to control my cholesterol level. I stopped simvastatin and all fibrillations have disappeared. As I was taking simvastatin, I was in fibrillation 17% of the time; 1 month after I stopped simvastatin, the level was down to 0%. I am now experimenting with alternative cholesterol control methods: Omega 3 gels, ground linseed, charcoal.

) For the past 20 years, I have avoided NSAIDs, acetaminophens, other pain relievers and muscle relaxants because of their adverse effects to liver and kidneys (personally more significant because my dad had kidney disease). Since cannabidiol inhibits the liver's production of cytochrome P450, I am wondering about switching from simvastatin to pravastatin. That would allow me to try CBD, which appears to have minimal side-effects.

Have you had your CK level drawn? This lab value will discern if any muscle damage. Do you have a copy of any labs? Please voice your concern to your physician, do not EVER sit in silence and hope the side effects will go away. This could be serious!!! Again, SEE YOUR PHYSICIAN,and do let me know.

check also who is making the research on simvastatin, and that liver damage has been removed recently, at least here in italy

They read up on all of her meds called the Dr. he stopped the simvastatin and she is much better now and cont to improve. My husband is on it and has no problems. As with most drugs, they affect people different.

I think it's more of which one your body will tolerate the best. Different brands seem to show different side effects in many people. Lipitor in some women have produced breast pains or enlargement and even the manufacturers cannot explain that one. Still, I suppose it's cheaper than plastic surgery. Some statins cause abdominal pains in some people, or nausea or serious muscle cramps and even damage.

Tenofovir and Entecarvir only stop or reverse liver damage. Yes, it could help you get undetectable HBV DNA, but it also worsen your liver cells' infection? Does that even make sense? Because they inhibit HBV from growing, should they lower your virus load, then your liver should become less infected, and have time to repair itself? Alinia seems promising at dose 2g/day for HBeAg negative.

I'm on Simvastatin (40mg) which have some nasty side effects, like cramps and muscle spasms. Can you reommend an alternative?

Also, unusually, after sitting or being in bed, I get regularly,involuntary muscle spasms mostly affecting the stomach and eqivalent area in the back. There is no pain, just annoying sensation and the wanting to stretch all the limbs. Medication is usual heart stuff following 2008 attack, I don't think Simvastatin is to blame and at the moment Tramadol to help at night.

This can be very dangerous and can cause a variety of health problems, such as liver damage or a rare condition called rhabdomyolysis (severe muscle and kidney damage).

sorry i think liver damage sides have little research to confirm it, it looks like sim improves liver function in cirrhosis by improving blood flow http://www.ncbi.nlm.nih.

Just finished Tx 6 months post UDT and now have been prescribed simvastatin for cholestral. I'm 3/3.5 damaged and was wondering if this is the right aveune to take for meds . Will the hep C be reactivated or will my liver get worse now that its trying to get better. Blood work will follow in 30 days. The VA prescribed Zeitia and my new outside Dr recommended to try the Simvastatin ( Zocar) and stop the Zeita. Does this make any sense to anyone? Any comments are appreciated .

As you know, I was on Vytorin for years and went back to Simvastatin about a year ago. I have tested twice since on Simvatstain alone and my numbers have actually dropped a little than during my Vytorin days. I'm only going by the Enhance trial that concudes; "The ENHANCE study enrolled 720 patients who were randomized to receive either Vytorin, or Zocor alone. As an endpoint, investigators looked at the growth of plaques on arterial walls using non-invasive ultrasound imaging.

Simvastatin and muscle damage

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