propranolol and portal hypertension

I am assuming you have esophageal varicies due to your portal hypertension and that is why you are taking the beta blocker propranolol to treat your portal hypertension is that correct?

So you are already taking 10mg of propranolol for your portal hypertension caused by your portal vein thrombosis (PVT). Propranolol is the most commonly used drug for portal vein obstruction. Combined with endoscopic banding treatment they are the standard first line of treatment. Do you know why she don't just increase the dosage? Now she wants to add another beta blocker in addition to propranolol? Has your doc talked to you about anticoagulation therapy?

If so an enlarged spleen is a complication that occurs because of the cirrhosis and the resulting portal hypertension. It is a condition that is the result of the cirrhosis and portal hypertension and not a condition of the spleen itself. There is no treatment for an enlarge spleen resulting from cirrhosis. Only when the cirrhosis is reversed can the enlargement of the spleen be resolved.

I have read where peole with portal hypertension should not lift weights.Supposedly it increases the pressure and you already have varies, this could b/c dangerous situation. Talk to your Hepatologist or GI doc. and get a more definitive answer before lifting weights.

The preferred, albeit indirect, method for assessing portal pressure is the wedged hepatic venous pressure (WHVP) measurement, which is obtained by placing a catheter in the hepatic vein and wedging it into a small branch or, better still, by inﬂating a balloon and occluding a larger branch of the hepatic vein. This is rarely done as the exact pressure is not needed and what is important is to stop the resulting complications such as life-threatening variceal bleeds. Also .

He does not drink and has never taken drugs, untilt his event. This was not his prescription of propranolol, it was a family memebers. can this be drug induced hepatitis, can it be reversed, or is it usually permanent damage. If in fact this is drug induced hepatitis, does the dmage continue, or did it stop after the drugs were out of his system? Thanks for any help.........

Portopulmonary hypertension is reported to occur in 2%–5% of patients with liver cirrhosis and portal hypertension. Three mechanisms are thought to play a causal role: First, vasoactive substances such as serotonin, interleukin 1, endothelin 1, and thromboxane, which may cause vasoconstriction and mitogenesis in the pulmonary arteries, escape hepatic detoxifying mechanisms through portosystemic shunts or are not cleared as effectively by the diseased liver.

However reduction in portal hypertension is possible through the use of nonselective beta blockers, particularly propranolol and Nadolol. These medications reduce portal pressures both by decreasing cardiac output and by producing splanchnic vasoconstriction. Several studies have shown that nonselective beta blockers decrease the risk for first variceal hemorrhage by 40% to 50% when compared to patients taking placebo.

I'm 29 and was diagnosed 8 years ago with portal hypertension due to a chronic schistosoma infection (therefore had an enlarged spleen, ascites and jaundice at the time). Since then I've been taking a low (I believe) dosage of spironolactone, propranolol and furosemide to control my blood pressure and water retention. Me & my man really want to have a baby within the next few years, and we're concerned about the possible complications/risks arising from this: 1.

Portal hypertensive gastropathy (PHG) is part of a complex syndrome which occurs as a complication of chronic liver disease and portal hypertension (PHTN). At endoscopy, the gastric mucosa shows that mosaic-like pattern and red marks, which are the source of gastric bleeding. Only the severe form of gastropathy is liable to bleed.

Hi. Thank you for writing. Note that a beta-blocker treatment will not stop or prevent varices. Varices are a complication of cirrhosis and can only be "cured" when a person no longer has cirrhosis. The good news is that varices and the portal hypertension can usually be controlled (reducing the blood flow and pressure) with use of a beta-blocker.

I find so much info on treatment and cirrhosis but cannot find anything on spleen or portal hypertension. I hope it helps and hope your uncle continues to do well!

Do you take any medication? Have you seen a doctor? If yes, do you have any diagnosis : heart or something else?

how bad is portal hypertension,and how long does it take to become a very nasty problem

The effects of different types of adrenoreceptor blocking agents on portal venous pressure were studied in patients with cirrhosis and portal hypertension. Oral atenolol (selective beta 1 blocker), propranolol (non-selective beta 1 and beta 2 blocker), and prazosin (alpha blocker) were compared in three groups of eight patients. Haemodynamic measurements were made before and after two or three and eight weeks of therapy.

TIPS is the only way to mdecrease portal hypertension appreciably. There is still some hope that there can be some interval improvment but more likely not.

HCC is primary liver cancer, which cirrhosis predisposes to. the portal hypertension will lessen and hopefully resolves over time but the sdcarring in the liver takes a much time to regress and that is what places the individual at risk. I do not think that you reached the point of no return so keep doing what you're doing.

So it depends on how much portal hypertension she has. If her portal hypertension were servere the center would be worried about internal bleeding of varices. Is she on a beta-blocker such as Propranolol or Nadolol. If they only want to see her yearly, she must have a relative early stage of cirrhosis and portal hypertension. It is generally only when a patient decompensates or has a MELD score over 20 that they can't be treated with current treatment therapy.

Varices and variceal hemorrhage are the complications of cirrhosis that result most directly from portal hypertension. Patients with cirrhosis and gastroesophageal varices have an HVPG of at least 10-12 mm Hg. Gastroesophageal varices are present in approximately 50% of patients with cirrhosis. Their presence correlates with the severity of liver disease (Table 2); while only 40% of Child A patients have varices, they are present in 85% of Child C patients....

Scar tissue in the liver (caused by scaring of the liver/cirrhosis) can interfere with that blood flow...... causing pressure to build up in the portal vein (portal hypertension), and the spleen to enlarge (splenomegaly). As the spleen enlarges, it traps platelets. (The amount of platelets in the bloodstream is reduced.) So usually--- people with cirrhosis end up having a problem with portal hypertension and an enlarged spleen, and a reduced platelet count in the bloodstream.

I can tell you from experience, after bleeding out 3 times, once a Mallory Weiss Tear, once lower GI Bleed and once 10 varices burst. I suffered from every known life threatening complication of Portal Hypertension short of Kidney Failure. What saved my life was a procedure known as TIPS (Transjugular Intrahepatic Portosystemic Shunt) placement (aka DIPS), where-in they bypass a percentage of the blood pumping up the Portal Vein from the digestive track into the liver.

Propranolol and portal hypertension

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