Am currently taking Prograf in larger amounts than .5 and it is negatively effecting my kidney function.
My current dose is Prograf 3 mg AM/ Prograf 3 mg PM and Rapamune 4 mg AM. The intent is to convert me to 100% Rapamune because of the nephro-toxicity of the Prograf and my young age and because of the anti-cancer properties of Rapamune. Data, while horribly limited, has shown Rapamune's anti-cancer properties have had success against vascular tumors such as mine so EHE, in this case chronic, is part of the cancers Rapamune affects (some cancers it has no effect).
For this reason, it works as an anti-rejection medicine. Prograf helps patients who have had a liver/kidney transplant protect their new organ and prevent it from being rejected by the body. This medicine can cause the amount of potassium in your blood-stream to increase. For this reason you should avoid large amounts of foods that have a high potassium content, for example dried fruit, bananas, tomatoes and low sodium salt, while you are taking this medicine, also avoid potassium supplements.
both are normal site, size and shape w/ good cortico medullary differentiation, no cyst, no focal lesion or back preasure changes could be detected.
-Pancreas & Paraaortic area: masked by gases, mild ascites and peripslenic collection seen.
-Urinary bladder: suboptimal filling and wall thickness with no stones, filling defects or diverticulae
-Prostate: is mildly enlarged measuring 34gm in wieght intact capsule and homogenous echopattern, no pelvic masses.
Prograf is toxic and in the long run it can cause kidney failure. Right after my transplant, I was put on 10 mg. Prograf daily. Gradually, the doctor lowered it to 5, then 4, and so on. Last month, the doctor lowered it to 1.5 mg. daily. That is low and I had to give blood one month after the dosage was lowered so the doctor could see if it was too low. I'm happy now with 1.5 mg. In a few months, I will again as the doctor to lower it.
My husband had a liver transplant on Aug.5th - and has been **** well. Today he broke out in hives all over his head. He is itching terribly - and the 2nd Benadryl hasn't helped. He is on Cellcept, prograf, and is in a clinical trial (so we don't really know what the extra meds are). Should we be concerned???
If i lower my prograf lower than 6.5 through rate i start getting discomfort right side .i am having cognitive issues on prograf that are getting very hard to live with, seems like it got alot worse after my last of three mri with contrast in two years. was hospitalized two days after last contrast exsposure white blood count went to1000, headach, fever urine got exstremly foamy, severe itching ,tighting and rashd eveloped on lower legs two weeks after.
I believe that diarrhea can cause an elevation in Prograf level. Taking Prograf with food can decrease absorption and result in a lower Prograf level. This is even more pronounced if you take it with fatty food. If Prograf doesn't upset your stomach it is best taken about 1 hour before eating - on an empty stomach.
The range on my labs sheet is 4 - 16 so you are well within range.
Pentamidine (aerosol) 1x monthly, Prograf 2mg 2x daily, metroprolol tartarate 12.5mg 2x daily, magnesium oxide 400mg 2x daily, oscal, multi vitamin, vitamin d3 1000iu 1x daily. Thanks.
I'm geno type 3. I've heard Prograf is harder on the kidneys than sirolimus which is why they switched me from cyclosporine to sirolimus. That's probably why they haven't suggested switching me to Prograf in fact this is the first time I'm hearing about Prograf or Tacrolimus (it's other name as I found on the web). Thanks for your response and congrats on your great report since week 4 !
I went into rejection twice in the hospital and because of this my transplant team saw it best to put me on 5mg of prograf twice a day as well as 4 mg of rapimune, which by the way was off label and i had to sign a release form for. Just within the past 2 months they lowerd my dosage of rapimune to 2mg but kept the prograf the same. My question to you is exactly how suppressed is my immune system?
I was diabetic since I was in 5th grade, but five years ago had a kidney;pancreas transplant. Since then I have been on three kinds of drugs for my transplant. Cellcept, Predizone, and Prograf are the drugs that I am taking. With these drugs along with having diabetes up until 5 years ago affect my chances of producing a child. I am also 32 years of age.
I got a kidney transplant in May 2000..2004 my disability and medicare got canceled.. so I have not been able to afford the extremely expensive immunnosuppression medication Prograf..well its 2010 and im still here ..this world really bothers me with the lack of geniune caring for those who have been dealt a bad deck..My name is Trek im 38 who had beautiful daughter after kidney failure. Need let help here...advice knowledge whatever also looking for work!!!!
I am 6 years post liver transplant from genotype 3 Hep C. My doctors want to start treatment to clear the virus. I take Prograf for the liver transplant and I know Naragenin affects the Prograf levels. My question is if during treatment I also took Naragenin and my prograf levels were closely watched and adjusted for the Naragenin effects, wouldn't I have a better chance of clearing the virus.
My history: liver transplant 1 year ago, had 2 moderate rejections and 1 mild since transplant. At present time having moderate rejection, recently had one portal stent and 8 Bilary ERCP's to remove stones and sludge and had stenting done, and at the present time there are no blockages. Was on Rapamune (5mg a day) prior to hernia surgery and then week before hernia surgery was put on Prograf (4mg a day) and taken off the Rapamune. I have been on Progaf since hernia surgery (8 weeks ago).
If suppressants are at the correct trouph levels, say, Prograf and Rapamycin, what are the next steps - switch suppressants, treat?
t understand the relationship between treatment and Prograf dose. It sounds logical to think that the higher the Prograf dose the less likely TX will be successful and, at the extreme, I think that's probably true. But, whether 3 mg per day or 6 mg Prograf per day makes any difference is a question I cannot answer.
When I treated there was a reluctance to dose the way a non-transplant patient would have been dosed and that can be and, in my case, was problematic.
Recommended
