Prograf is toxic and in the long run it can cause kidney failure. Right after my transplant, I was put on 10 mg. Prograf daily. Gradually, the doctor lowered it to 5, then 4, and so on. Last month, the doctor lowered it to 1.5 mg. daily. That is low and I had to give blood one month after the dosage was lowered so the doctor could see if it was too low. I'm happy now with 1.5 mg. In a few months, I will again as the doctor to lower it.
I have three kids with a life-threatning bone marrow failure disease and I do know how you feel. I am also sick and having problems with my kidneys, heart and lungs. We know all too well the saddness in Americas Health care. No one gets it until it happens to you or a loved one. The crazy people for life, vote to cut health care cuts to Medicaid and Medicare. There are kids who die all the time post transplant if they even get a transplant.
My current dose is Prograf 3 mg AM/ Prograf 3 mg PM and Rapamune 4 mg AM. The intent is to convert me to 100% Rapamune because of the nephro-toxicity of the Prograf and my young age and because of the anti-cancer properties of Rapamune. Data, while horribly limited, has shown Rapamune's anti-cancer properties have had success against vascular tumors such as mine so EHE, in this case chronic, is part of the cancers Rapamune affects (some cancers it has no effect).
My history: liver transplant 1 year ago, had 2 moderate rejections and 1 mild since transplant. At present time having moderate rejection, recently had one portal stent and 8 Bilary ERCP's to remove stones and sludge and had stenting done, and at the present time there are no blockages. Was on Rapamune (5mg a day) prior to hernia surgery and then week before hernia surgery was put on Prograf (4mg a day) and taken off the Rapamune. I have been on Progaf since hernia surgery (8 weeks ago).
everything was great for first 7 mths. Then they changed his transplant meds from prograf and cellcept to rapamune and cell cept. Thats when it all went bad. He went into resp. arrest 4 times in 1 month, kidney failure, acted like he was drugged, twitched, and spent many weeks in the hosp. We tried to tell the docs that it was the new meds, he was also on vancomycin, and they would not listen they kept saying it was the pain meds he had been taking for years but we knew better.
My husband had a liver transplant on Aug.5th - and has been **** well. Today he broke out in hives all over his head. He is itching terribly - and the 2nd Benadryl hasn't helped. He is on Cellcept, prograf, and is in a clinical trial (so we don't really know what the extra meds are). Should we be concerned???
Its kind of the same feeling i had after my transplant when i was on hi doses of prograf. Any ideas ? Can i try lowering my prograf to try and alievaite this cognitive impairment by adding maybe some cellcept? I have never been on anything but prograf alone except prednisone 6 mo tx .My mouth stays extreamly dry tounge seams to be affixed to my roof of mouth with a tight jaw week muscels and eyesight since contrast. nobody seems to be able to offer any direction.
The two things that pop into my head when an older animal starts to drink excessively and urinate in the house are kidney failure and diabetes, although there can be other reasons. A trip to the vet is definitely in order ASAP. If you catch it early, kidney failure is something that an animal can live comfortable with for quite a few years, so don't panic.
I'm 61 years young and had a full liver transplant 2 1/2 months ago. Prograf levels go from 7 to 13.6 back to 6.5 Could it be the new lab that is screwing up. I take all 52 pills on time dailywith a wonderful hubby making sure.
I lost my dog in August of 2006 from kidney failure. She was lethargic and had no appetite, so I took her to the vet. He thought she could recover with iv fluids, etc. and so she spent 4 days at the vet clinic. She didn't like other dogs or the vet, so I still feel bad that this is where she spent the last few days of her life. In the end they couldn't do anything for her so I had her put to sleep. It was a very difficult thing. I found the following website very useful.
Recommended
