It is caused by various mechanisms
related to structural or functional abnormalities of the mitral apparatus, adjacent myocardium, or both. The most common causes of mitral regurgitation are myxomatous degeneration, chordal rupture, rheumatic heart disease, infective endocarditis, coronary artery disease, and cardiomyopathy.
Mitral valve prolapse (MVP) is the systolic billowing of one or both mitral leaflets into the left atrium during systole.