In all phase 2 and 3 trials‚ medullary bone pain‚ reported in 24% of patients‚ was the only consistently observed adverse reaction attributed to Neupogen® therapy. This bone pain was generally reported to be of mild-to-moderate severity‚ and could be controlled in most patients with non-narcotic analgesics; infrequently‚ bone pain was severe enough to require narcotic analgesics.
A CBC and platelet count should be obtained before instituting Neupogen therapy‚ and monitored twice weekly during therapy. Doses may be increased in increments of 5 mcg/kg for each chemotherapy cycle‚ according to the duration and severity of the ANC nadir.
Neupogen should be administered no earlier than 24 hours after the administration of cytotoxic chemotherapy. Neupogen should not be administered in the period 24 hours before the administration of chemotherapy.
I had awful bone pain when I was on Neupogen. I've always contended for me, the side effects from Neupogen were as bad if not worse than those from antiviral therapy. It stimulates the colonies of white stem cells within the bone marrow causing the level of neutrophils in the blood to rise. It is common to have aching bones and joints for 2-3 days duration starting 1-2 days after the start of the injections.
The recommended starting dose of Neupogen is 5 mcg/kg/day‚ administered as a single daily injection by SC bolus injection, by short IV infusion (15 to 30 minutes)‚ or by continuous SC or continuous IV infusion. A CBC and platelet count should be obtained before instituting Neupogen therapy‚ and monitored twice weekly during therapy. Doses may be increased in increments of 5 mcg/kg for each chemotherapy cycle‚ according to the duration and severity of the ANC nadir.
//www.medhelp.org/posts/Hepatitis-C/Some-clarification-if-someone-knows-or-doctor-has-explained/show/1656098?
i started neupogen since my 4th week and went 48 weeks. still need neupogen occasionally even 6 months post treatment how. i would recommend seeing a hematologist. mine has been wonderful. he says he's not so worried about using neupogen as "holy water" but if you are on procrit, he would be a little concerned. neupogen really helped me stay on treatment so i could finish 48 weeks.
Neupogen works within hours. I take one shot a week, prolly should take two. It does what it's supposed too while physical effects have been zero.
Someone correct this if wrong. Neup is used to increase WBC/ANC count. WBC is essentially the immune system. A low WBC count won't cause fatigue. Low RBC and Hemoglobin will since it transports oxygen.
Your ANC calculates to around 1.24. You are still within acceptable range.
Low white blood cells is very typical with antiviral therapy. Many of us don't even start Neupogen until our ANC is below 500. Different doctors have different thresholds at which they feel intervention with Neupogen is necessary.
It is a known fact that HCV therapy(specifically INF. can reduce neutrophil counts (neutropenia) in patients quite often.
However it seems clear from the thousands that have been involved in the studies below that there seems to be" little" if "none" at all correlation between low neuts(ANC) and increased incidence of infection.
The labeling on INF.
The Hematologist said he was going to start him on Neupogen is anyone else taking this and is it working for them. He also said that he may need a transfusion , which is freaking my husband out because that is how we suspect he contracted the Hep c orignally (back in the 80s). I told him that they screen the blood much differently now then they did back then , but he is still freaking out. Anyone who is taling Neupogen please let me know if it is helping.
Ok so I've been on cephalaxin for 10 days, went off for 1 day, and now infection is back so skin doctor wants me to do another 10 days. Just got blood test results, neutophils are around 600, so doc doesn't want me to take shot until I have more blood work done. I am ten weeks into treatment, and I don't understand why neupogen isn't an option. I go for my twelve week test in two weeks and am already nervous about that.
I am afraid it will force me to discontinue the therapy. Has any one exprienced such problem during therapy? please give me some advice how can i prevent this infection. I am really ashamed of having such thing around my privet areas.
I am at 21/48 week, current WBC count is 1600. At 12 week blood test was UND, liver and kideny enzymes are still normal.
This shows the dosing information for neupogen while on hcv tx. According to this information the neupogen should be stopped or taken less often if the anc is over 1000. Mine was at 6500 after five injections, and my doc tells me to keep taking the neupogen.
Granulocyte Stimulating Colony Factor Criteria for Use
for Hepatitis C Treatment-Related Neutropenia
VHA Pharmacy Benefits Management Strategic Healthcare Group and Medical Advisory Panel
Prepared by: K. Tortorice, PharmD BCPS , H.
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