The recommended starting dose of Neupogen is 5 mcg/kg/day‚ administered as a single daily injection by SC bolus injection, by short IV infusion (15 to 30 minutes)‚ or by continuous SC or continuous IV infusion. A CBC and platelet count should be obtained before instituting Neupogen therapy‚ and monitored twice weekly during therapy. Doses may be increased in increments of 5 mcg/kg for each chemotherapy cycle‚ according to the duration and severity of the ANC nadir.
A CBC and platelet count should be obtained before instituting Neupogen therapy‚ and monitored twice weekly during therapy. Doses may be increased in increments of 5 mcg/kg for each chemotherapy cycle‚ according to the duration and severity of the ANC nadir.
Neupogen should be administered no earlier than 24 hours after the administration of cytotoxic chemotherapy. Neupogen should not be administered in the period 24 hours before the administration of chemotherapy.
Several questions were raised in the thread:
http://www.medhelp.org/posts/Hepatitis-C/What-is-absolute-Neutrophils/show/1280368
about the causes of HCV treatment induced neutropenia (low neutrophil counts) and I thought it would be interesting to learn more about this part of treatment.
Specifically, they are:
- what is the incidence of neutropenia due to interferon monotherapy?
- what is the incidence of neutropenia due to ribavirin monotherapy?
However, since he does not have fever, it is unlikely your husband has that type of infection. Chemotherapy, and radiation therapy are the other causes. Other common causes of low WBC are flu, lupus, Hodgkin's lymphoma, some types of cancer, typhoid, malaria, tuberculosis, dengue, enlarged spleen or hyper-spleenism, and folate deficiency. Please discuss with his treating doctor to run tests to find the cause. If all these are ruled out, then it can be bone-marrow suppression.
Take care!
In the last four years the PSA has slowly crept higher reaching 0.577 in August of 2008. I recently scheduled radiation therapy with my radiation oncologist, but I am quite concerned about the side effects, especially permanent side effects. I am wondering if I am rolling the dice with a loss of quality of life, in trade for a possible three or four extension of life span. Could you please address these concerns. Thank you for your consideration.
Use of erythropoiesis-stimulating agents to achieve a target hemoglobin of 12 g/dL or greater in cancer patients shortened the time to tumor progression in patients with advanced head and neck cancer receiving radiation therapy; shortened overall survival and increased deaths attributed to disease progression in patients with metastatic breast cancer receiving chemotherapy; and increased the risk of death in patients with active malignant disease not under treatment with chemotherapy or radiat
Dont know enough about radiation therapy to make a decision to have the treatment. Drs have strongly recommended to. Have researched on internet side effects. Need to know percentages for reoccurance with and without treatment. I do have other calsification sites in right and left breast not active. Very confused and worried about making right decision as to what to do next.
This discussion is related to <a href='/posts/show/1496'>Radiation therapy only for DCIS</a>.
In all phase 2 and 3 trials‚ medullary bone pain‚ reported in 24% of patients‚ was the only consistently observed adverse reaction attributed to Neupogen® therapy. This bone pain was generally reported to be of mild-to-moderate severity‚ and could be controlled in most patients with non-narcotic analgesics; infrequently‚ bone pain was severe enough to require narcotic analgesics.
Ok so I've been on cephalaxin for 10 days, went off for 1 day, and now infection is back so skin doctor wants me to do another 10 days. Just got blood test results, neutophils are around 600, so doc doesn't want me to take shot until I have more blood work done. I am ten weeks into treatment, and I don't understand why neupogen isn't an option. I go for my twelve week test in two weeks and am already nervous about that.
I clicked on the thread that bluebutterfly kindly provided. It doesn't address the question of the original poster - which is the what are the long-term effects of radiation. These are extensive - radiation therapy has long-reaching effects on the body's systems - particularly if rec'd at a young age - I was under 20 - it caused my later breast cancer. It is the reason I am at substantial increased risk for stroke and heart disease (it causes hardening of the arteries).
I had awful bone pain when I was on Neupogen. I've always contended for me, the side effects from Neupogen were as bad if not worse than those from antiviral therapy. It stimulates the colonies of white stem cells within the bone marrow causing the level of neutrophils in the blood to rise. It is common to have aching bones and joints for 2-3 days duration starting 1-2 days after the start of the injections.
It seems to me that there is a lot more risk in taking tamoxifen for 5 years -then 5 - 8 weeks of radiation therapy, if that's the case, why would tamoxifen be recommended over radiation?
My question is that I have talked to people who have had mastectomies and no hormone therapy. First I want to know if HT is standard care in my case and seocnd I want to know if HT is standard with mastectomies for my type of cancer. While I understand that you cannot anser this for me, I want to know if in some medical circles HT is omitted for my situation. I am asking becasue I want to know if it is worth it for me to seek a second opinioin.
They do prefer radiation to begin the following week.
It was Stage 0 - ductal carcinoma in-situ and the doctor is recommending radiation therapy... 6 weeks, 5 days a week. She was leaning toward the mastectomy to be done with it but he says for her age it's a very rough surgery to go through. She has now been told by a friend that her sister had radiation therapy for breast cancer and came down with rheumatoid arthritis as a result. I've tried to research this on line but find nothing on it.
The overall survival was 47 percent and 37 percent, respectively. Radiation therapy also significantly reduced biochemical and local failure as well as the need for androgen ablation (or hormone therapy).
A PSA rise at this point would not necessarily mean metastatic disease. It is not clear if distant micrometastases would evolve before PSA elevation. It could mean prostate tissue was left in the body (not necessarily a positive surgical margin but a capsular invasion) or micrometastases.
I am not cirrhotic, my WBCs and ANCs were normal prior to treatment, my ANC went to 280 at week 6 and I developed a bacterial infection in my ear and throat and was put on antibiotics and neupogen. I read about one person on this forum (can't remember who it was) whose ANC went to 0 and was hospitalized with bacterial pneumonia and put on intravenous antibiotics and neupogen. Although it seems obvious that neupogen is overused, I am not sure that it should never be used.
He reassured me that the side effects from both radiation and drug therapy are minimal in the majority of the population. He told me that I was young (I said, "I'm 49!" and he said, "that's young!") and that I was relatively healthy and that I'm likely to handle the short term side effects very well. He agrees that the numbers show that the risks of long term detriments due to treatment are far outweighed by the risk of dying of cancer without the treatment.
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