neupogen g-csf

Does a drug such as Neupogen (G-CSF) increases the possibility of rejection due to increased WBC? Or is rejection caused by another part of the immune system rather than WBC and ANC?

however, most sophisticated hematologists/hepatologists will allow their patients to drop to about 500 before either dose reducing or prescribing G-CSF drugs such as Neupogen. Some docs will allow their patients to drop to .30-.35 before they intervene. The obvious choice is to use the Neupogen; continuing on full-dose interferon is the best way to ensure that you eventually achieve SVR.

These data suggest that further meticulous studies are required to determine the criteria for dose reduction and to define the use of G-CSF for PEG-IFN-induced neutropenia. ------------------------------------------------------------------------------ In this study 2876 patients: http://www.ncbi.nlm.nih.gov/pubmed/20830784?dopt=Abstract# Bacterial infections during treatment with peginterferon alfa and ribavirin are not associated with neutropenia.

Among recipients of high-dose chemotherapy for the management of hematologic malignancy, neutropenia is highly correlated with risk of infectious complications [7]. In this patient group, G-CSF reduces the duration of neutropenia [8–10]. G-CSF has been demonstrated to be useful in reducing risk of infection in some [9, 11], but not all, studies [8, 10, 12]. This specific beneficial effect diminishes with increasing age. Overall mortality is generally not altered by the use of G-CSF.

Not much to add here as the advice is excellent. You ask what you can do outside the G-CSF (is that Neupogen) to help. I think the answer is, not much. It is the interferon that reduces the absolute neutrophils and it will continue to do that, with or without the Incevik. Idyllic...

to compare the effectiveness rate of sustained viral response (SVR) in patients with Pegylated Interferon dose modification and in patients treated by using granulocyte colony-stimulating factor G-CSF-filgrastim. (Neupogen). Study enrolled 47 patients with chronic active hepatitis C, aged 23-64. (38 male and 9 female). All patients had HCV genotype 1b. Significant neurtopenia (ANC<750 mm3) and severe neurtopenia (ANC<500 mm3) developed in 41 of 47 patients (87%).

He was probably referring to Neupogen which is also known Filgrastim which is a human granulocyte colony-stimulating factor (G-CSF). Basically, it encourages the growth of the white blood cels that the Interferon depletes with treatment. For more information go to neupogen.com The riba, similarly, depletes red blood cell. If your hemoglobin gets low they might also prescribe Procrit for that. Go to procrit.com to learn about that stuff.

Have been trying to cost what a ceiling amount might be for a 12 week period to see if I can organise sufficient funds. Neupogen in prepared syringes are sold in packs of 10 - $1504 for 3000mcg/.5ml shots and $2407 for 480mcg/.5ml shots. I realise that amount required is case dependant but wouldnt mind any info which might assist me to at least get some idea of the range which may generally apply.

"I know my spleen is enlarged but I figure it's working overtime trying to get my blood counts back to normal levels." That is NOT TRUE. The spleen does NOT get enlarged for that reason. If your spleen was NOT enlarged before you started treatment, the fact that it is enlarged now would be worrisone. I'm not sure using Neupogen on somebody who has an enlarged spleen is safe since Neupogen can cause the spleen to rupture.

Okay, yesterday I mentioned that I'd requested the full reports after the neuro's office sent postcards informing me all is well. No idea how much any of this means (that's why I come here, of course), but here's what I'm picking up out of the repoorts that came today. Under the heading "Immunoglobulin G Index," it lists IgG, Quant, CSF, 1.8 mg/dL, limits 0.0 to 8.6. Albumin, CSF, 56 mg/dL, limits 11 - 48 (flagged as high).

Congrats girl on UND! I'm on an antibiotic for bladder infection. Still no rescue drugs, but 90 of peg this week again. I can't WAIT to get my 12 week! So happy for you!

9 yes NYG reminded me about tylenol and I have been taking more because of neupogen at night. Neupogen is evil, and look at my WBCs! They are still in alarm after two a week!

If it is the HAX1 mutation, there is probably no cure, per se. But you might get a drug such as G-CSF (granulocyte colony stimulating factor aka Neupogen), which is typically used for cancer patients whose neutrophils get dangerously low from chemo drugs. Did you ever have a blood smear? (They look at blood cells with a microscope.

Neulesta or Neupogen are drugs to prevent white blood cell counts from dropping too low... I took the neupogen injectons and had to take them home with me.. I required 3 injections one 24 hours after chemo and then 1 each day after fora total of 3 With that said they can cause severe bone pain.. Just ask your oncologist for a pain reliever and you can get through it.. NOthing is ever as bad as it appears before you do it...

You can ask your hematologist for G-CSF injection if you have persistent neutropenia. Patients with CML are immunocompromised and can easily acquire infections. Neutropenia also puts a patient in an immunocompromised state. For now, it is very important to prevent acquiring any infection. You should avoid crowded places and persons with ongoing infection. Good luck.

In the absence of data, reduction in IFN dose and/or G-CSF dose for those who develop neutropenia while undergoing IFN-based therapy for HCV infection are often initiated in clinical practice, as suggested in treatment guidelines [6] and mandated in most clinical trials [15]. Reduction of IFN dose is well accepted to have a detrimental effect on the rate of sustained virological response [2].

to compare the effectiveness rate of sustained viral response (SVR) in patients with Pegylated Interferon dose modification and in patients treated by using granulocyte colony-stimulating factor G-CSF-filgrastim. (Neupogen). Study enrolled 47 patients with chronic active hepatitis C, aged 23-64. (38 male and 9 female). All patients had HCV genotype 1b. Significant neurtopenia (ANC<750 mm3) and severe neurtopenia (ANC<500 mm3) developed in 41 of 47 patients (87%).

His approach was not as conservative as mine, since I was hoping to monitor the levels, rather than jump into the neupogen shots. I thought best to not push things too much since he did a good job of scaring me about potential infections and result of high fever, etc. So looks like I begin with 2 shots per week to start, monitor the levels as I go and follow up with an appt in 2 weeks. He did indicate that most have no sides, but some have “achy bones” from the neupogen.

The Hematologist said he was going to start him on Neupogen is anyone else taking this and is it working for them. He also said that he may need a transfusion , which is freaking my husband out because that is how we suspect he contracted the Hep c orignally (back in the 80s). I told him that they screen the blood much differently now then they did back then , but he is still freaking out. Anyone who is taling Neupogen please let me know if it is helping.

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