In cobalamin deficiency, 2
mg of cyanocobalamin administered orally on a daily basis was as effective as 1
mg administered intramuscularly on a monthly basis and may be superior."
Almost any substance may be used sublingually if it dissolves easily in saliva. However, factors that can affect absorption include oral pH, salivary enzymes, lipid solubility, and molecular weight (molecules may be too large to pass through the mucous membranes).