Can I also post a question about Tramadol, anti-deps and zopiclone? I saw this post and read it with great interest, as I am experiencing the terrible symptoms Doseduk mentioned, in regards to these combos. I have been on 3 anti-deps, Mirtazapine, Pamelor , Zoloft. I've posted on this a few times. My psych prescribed Zopiclone about 6 months ago. She faxes her report on me and what she's prescribing to my referring GP, so I thought my GP would know what meds my psych is prescribing.