He was given valparin chrono 300 mg one tablet in the morning and one tablet in the night .he never got fits thereafter.From June onwards we skipped the tablet in the morning and gave only during night.But in the month of february 2008 he got fits once again .Not only that the frequency also increased.He was given oxyetol-150mg half tablet along with valparin chrono 300mg .
Only a few interactions between lamotrigine and other drugs have been identified. Lamotrigine increases the plasma level of carbamazepine and its metabolites. Carbamazepine lowers the concentration of lamotrigine in the blood.
Valproate doubles the plasma level of lamotrigine, and the level of valproate is decreased by about 25% in people taking lamotrigine.
Phenobarbital and primidone lower the plasma level of lamotrigine by about 40%.
These are anti-epilepsy drugs such as valproate, carbamazepine, lamotrigine, phenytoin, gabapentin, and pregabalin; muscle relaxants such as clonazepam and baclofen; tricyclic antidepressants such as carbamazepine, amitriptyline, and nortriptyline. The other option is surgery: Stereotactic radiosurgery, cutting or destroying part of nerve or removing blood vessel or tumor pressing it. If there is a tumor or blood vessel causing the symptoms then medical treatment will not help.
I really feel better mentally, no depression or pain, with lamotrigine, and I am so sad that I might have to give it up. I just saw my doctor yesterday and since it is February, she thinks that may be it is just a stomach virus... I need to live my life without having to pull over at gas station rest areas constantly!
If this is caused by the lamotrigine, will I "adjust" and the diarrhea go away, or am I just really too sensitive to this medication?
During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
Your doctor will start you on low dose of lamotrigine and gradually increase your dose, not more than once every 1 to 2 weeks. You may be more likely to develop a serious rash if you take a higher starting dose or increase your dose faster than your doctor tells you that you should. Your first doses of medication may be packaged in a starter kit that will clearly show you the right amount of medication to take each day during the first 5 weeks of your treatment.
This reaction is generally confined to the extremities but can affect the trunk and face and may be irreversible. Severe dermatologic reactions to phenytoin are infrequent. Some evidence, however, suggests that erythema multiforme is more likely in patients who undergo radiation therapy while receiving phenytoin.[22]
Lupus-like symptoms have been described for phenytoin. Whether phenytoin administration will exacerbate preexisting idiopathic systemic lupus erythematosus (SLE) is unclear.
My son is 25 and has seizure disorder. This past Thanksgiving, he had a total of 5 seizures over 24 hours necessitating a hospital visit and stay. They put him on a third seizure medication (Lamotrigine). I spoke with a neurologist at USF who didn't like that a 3rd medication was added before his previous two were maxed out--he was already on Keppra (max dosage) and Depakote (sprinkles--very low dose), so she titrated him up on the Depakote so we could get rid of the Lamotrigine.
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
I was also on epilim and was taken off because of the weight gain, im now on lamotrigine, at the begining I found this to really lift my mood but then it wasnt enough so I was added some other medication, cant remember the name, I was ok for months but now for some reason I have started to cycle again.
Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm
Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.
Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
The study found five cases of oral clefts in infants in a study of 564 pregnancies (that is one in 113 cases) where the mother was taking lamotrigine and no other antiepileptic drugs. This is higher than the worldwide incidence which is one in 700."
Overall, there are reports for and against Lamotrigine in pregnancy. The treatment has to be individualized for each patient.
You will need a regular monitoring of the fetal growth.
My son is 25 and has seizure disorder. This past Thanksgiving, he had a total of 5 seizures over 24 hours necessitating a hospital visit and stay. They put him on a third seizure medication (Lamotrigine). I spoke with a neurologist at USF who didn't like that a 3rd medication was added before his previous two were maxed out--he was already on Keppra (max dosage) and Depakote (sprinkles--very low dose), so she titrated him up on the Depakote so we could get rid of the Lamotrigine.
I am currently taking Lamotrigine, Prazosin, and Quetiapine. I have also been diagnosed with H. Pylori, I was wondering if I could take Prevacid with these other medications? I have tried everything else and this would be a last resort.
I asked my neurologist about sleep and he told me to take the Lamotrigine 250x2 1 time/day. From my personal experience I would try the medications and keep a log of good or ill effects, for the first 30 days to adjust for half life and discuss them with the prescribing DR. If there are ill effects notify your DR immediately.
Ugh i'm on Lamotrigine and I accidentally took a whole pill and not a half and the next-ish day I had this sore feeling in a part of my throat I couldn't pinpoint , it was weird. I have continuously felt like I was on the verge of getting sick...Hm. I've been really thirsty lately, too.
If you are pregnant your doctor may gradually decrease the dose and stop it and may prescribe an alternative anti seizure medicine which is safe during pregnancy. Sudden withdrawal of antiseizure medication may precipitate seizures in a pregnant woman which can be dangerous for the fetus. Medicines are prescribed during pregnancy only if the benefits outweigh the risks. Your doctor may prescribe you high dose folic acid 4 mg to prevent spinal cord deformities. I sincerely hope it helps.
I'm in the Uk and currently taking Quetiapine, Depakote and Lamotrigine. The Quetiapine for me was prescribed for rage and agitation, I don't feel any anti depressant properties from it, but it has saved my life. Lamotrigine was prescribed 7 weeks ago and I feel a lot better, I am doing things that I didn't think I'd ever feel I could do again. Nobody has ever specified what type of Bp I have, I have symptoms from across the spectrum, I have mixed episodes.
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