One of the three patients was participating in a famciclovir trial and the other two were receiving lamivudine therapy for active hepatitis B infection. All three patients had documented hepatitis B flares, and all had hepatitis B virus DNA detected at that time. All patients developed decompensated liver disease despite one patient having had a prior liver biopsy showing absence of cirrhosis.
The only study that I was able to find online was done on macaque, it proves that there is no effect on infants and only insignificant quantity goes into the maternal milk.
http://www.ncbi.nlm.nih.
8%) developed HCC. Multivariable analyses showed that compared with lamivudine, entecavir therapy was associated with a significantly lower risk of death or transplantation (hazard ratio [HR], 0.49; 95% confidence interval [CI], 0.38–0.64), but a similar risk of HCC (HR, 1.08; 95% CI, 0.87–1.34). In the 1792 overall propensity-matched pairs, entecavir was again associated with a significantly lower risk of death or transplantation (HR, 0.49; 95% CI, 0.37–0.64) and a similar risk of HCC (HR, 1.
>>>Lamivudine has the least side effect and is the safest among other medicine types for husband and wife who wish to have children
Entecavir, which is much better in terms of the resistance issue, is not known to be unsafe for husband and wife who wish to have children. Please check with your doctor.
However, PEP always is comprised of combination therapy; neither lamivudine nor any other drug, used alone, has been studied. Doing so risks getting infected with a drug-resistant strain of HIV, so it could actually make things work.
2) It just doesn't. No medical condition has any such effect on HIV testing. It has to do with the complexities of the immune system. I'm not enough of an expert in that arena to give you a detailed biological explanation.
if you take it you will only worsen your condition very much because totally ineffective to clear hbv infection and because of the mutants you will have.the rate of mutations is very very high within one year of therapy, at 5 years therapy it is about 80% mutations, ones mutations happen the only drug working is tenofovir but you will have high cancer risk anyway.
Patients were treated with NAs therapy (lamivudine, adefovir, telbivudine, entecavir and tenofovir) for at least 2 years. qHBsAg was performed every 6 months.
Results
Our results showed a significantly greater qHBsAg decline after 2 years in patients treated with tenofovir (0.45 logIU/ml) than in patients treated with telbivudine (0.12 logIU/ml; P < 0.001).
I have Hep B positive for 15 yrs (since 1997). Was treated with Lamivudine ( Nov 2009 to Nov 2010). Feb 2012 test results shows HBV DNA 29426 copies/ml, ALT 54 U/L, Anti-HBe positive ( Competitive ELISA, Sample OD 0.116, cut-off OD 0.701), HBe AG Negetive, Fibroscan- CS(KPa) 1.7, IQR(KPa) 0.5.
Do I need medication right now. I got a Liver doctor appointment in April 2013. Can I wait till April or I should find other way of treatment?
Normally carriers are not treated, but your doctor must be having a sound reason to put you on Lamivudine therapy. It can be chronic Hepatitis B. You should try to find with your treating doctor and provide the final diagnosis.
The recent rise in ALT & AST ( Alanine & Aspartate Aminotransferase) may indicate one or more of the following:
1. You may have developed resistance to Lamivudine which is very common. Mutation analysis may clear this opinion
2.
Notes on "On-Treatment Management Strategies for Chronic Hepatitis B" Clinical Care Options, by Ira Jacobson.
1.
TDF switch effective in Asian chronic HBV patients
Posted in Hepatitis News
Switching therapy to tenofovir disoproxil fumarate is effective in treatment-resistant chronic hepatitis B, show results from a cohort of Asian patients. Administration of TDF resulted in a sustained virological response in the majority of nucleos ide analogue -experienced patients after nearly 2 years of follow-up, report the researchers.
Some do quite well and continue to work. Lamivudine is no longer considered a suitable first line therapy.
19 In people taking tenofovir disoproxil who have detectable HBV DNA at 48 weeks of treatment and no history of lamivudine resistance, consider adding lamivudine to tenofovir disoproxil. In people with a history of lamivudine resistance, consider adding entecavir to tenofovir disoproxil.
1.5.20 Consider stopping nucleoside or nucleotide analogue treatment 12 months after HBeAg seroconversion in people without cirrhosis.
1.5.
IFNa/pegIFNa, LAM, ADV, ETV, TDF or LdT may be used as initial therapy. ADV not preferred due to weak antiviral activity and high rate of resistance after 1st year. LAM and LdT not preferred due to high rate of drug resistance. End-point of treatment – Seroconversion from HBeAg to anti-HBe.
a similar safety profile as lamivudine in clinical trials. Studies in rodents exposed to doses 3 to 40 times that in humans found an increased incidence of lung adenomas, brain gliomas and HCCs.
L-deoxythymidine (Telbivudine/LdT, Tyzeka): well tolerated when used as monotherapy and has a safety profile comparable to lamivudine. However, cases of myopathy and peripheral neuropathy have been reported.
IFNa/pegIFNa, LAM, ADV, ETV, TDF or LdT may be used as initial therapy. ADV not preferred due to weak antiviral activity and high rate of resistance after 1st year. LAM and LdT not preferred due to high rate of drug resistance. End-point of treatment – Seroconversion from HBeAg to anti-HBe.
stop lamivudine immediately or switch to tenofovir, it is decades now lamivudine is not used because it can lead to cytopatic hbv mutations that cannot be control with any medication leading to cancer and cirrhosis despite hbsag negative, hbvdna undetectable and normal ast-alt, another reason not to use lamivudine is that it is even totally useless on hbv
the hbsag of the virus mutates to a form where the virus destroy cells directly even without replication
hbv cure is achieved only by sequen
Without taking any drugs, viral load was 22,000 in september 2009. 46,000 in december 2009. Doctor recommended lamivudine in January. Took lamivudine and by June 2010, viral load was undetected. have read in many forums that lam is not the best, approached my doctor with this concern and she sugessted tenofovir. Should i start tenofovir immediately, how should i start. Should i just abruptly stop lam and move on to tenofovir, should i use both and gradually stop lam after a few day/weeks.
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