5bn in 2017, with a compound annual growth rate (CAGR) of 1.3%. This slow growth is attributed to the patent expiry of Baraclude in 2015. Growth in the Hepatitis B market will be driven by the increase in the number of patients. The US is the largest market for Hepatitis B and it contributes to approximately 50% of the global market"
And a list with big players:
" Analysis of the current and future market competition in the global Hepatitis B therapeutics market.
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Abstract
Hepatocellular carcinoma (HCC) may still develop in chronic hepatitis B (CHB) patients treated with lamivudine. Whether HCC rates are comparable in patients treated with the current first-line antivirals remains uncertain. We estimated the incidence and evaluated predictors of HCC in a large nationwide prospective cohort (HepNet.Greece) of HBeAg-negative CHB patients treated with entecavir.
Would it be safe to use this unopened bottle as I have read that most medications are really good for 5 years after expiry and drug companies just put the expiry dates on so people will throw them away. I had my cataract surgery January 2011 so it is completely healed but I still have inflammation so I need to keep taking Voltaren eye drops.
stop lamivudine immediately or switch to tenofovir, it is decades now lamivudine is not used because it can lead to cytopatic hbv mutations that cannot be control with any medication leading to cancer and cirrhosis despite hbsag negative, hbvdna undetectable and normal ast-alt, another reason not to use lamivudine is that it is even totally useless on hbv
the hbsag of the virus mutates to a form where the virus destroy cells directly even without replication
hbv cure is achieved only by sequen
Without taking any drugs, viral load was 22,000 in september 2009. 46,000 in december 2009. Doctor recommended lamivudine in January. Took lamivudine and by June 2010, viral load was undetected. have read in many forums that lam is not the best, approached my doctor with this concern and she sugessted tenofovir. Should i start tenofovir immediately, how should i start. Should i just abruptly stop lam and move on to tenofovir, should i use both and gradually stop lam after a few day/weeks.
Hepatic decompensation was not prevented by lamivudine compared to placebo or entecavir compared to lamivudine in three underpowered trials.
Hepatocellular carcinoma was not prevented in four studies with inadequate size and duration. In one RCT, analysis that adjusted for country, sex, baseline ALT level, Child-Pugh score, and Ishak fibrosis score and excluded five individuals who developed HCC within the first year of the study found a borderline significant effect of lamivudine.
The hepatitis B virus eventually adapts to traditional treatments including lamivudine, adefovir and telbivudine, requiring patients to switch to an NtARTI drug.
IMS Health has estimated that the market for HBV treatments in China was worth $460 million in 2009, and will nearly triple to $1.3 billion in 2019.
Agenix is also currently involved in partnership and licensing discussions with potential allies for a phase III trial of ThromboView, its blood clot diagnostic technology.
Thanks for the reply! Still curious about any micro holes which could start forming after the expiry date? Or that's not the possibility...its just the risk of breakage after the expiry date?
10.300 copies/ml . I got lamivudine 100 mg /day vitamine E 4oo ui /day, orange juice everyday 50 cc/day ,and others fruits,2 months later my blood test showed DNA/HBV/PCR negative (<200 copies ),checked regularly every 3 months untill now still negative level. SGPT 75- 90 ui/ml constantly,never down a normal range,since 2008 March untill now. HBsAg negative level ,HBsAb negative level ,others test are normal levels .Is i got recovery from Hepatitis B ?
I have tested positive to Hbsag for more than a year now. I was placed on lamivudine, methionine and essential forte. d doctor never ask me to do viral load test anytime I see him he do ask me to do LFT and subject me to d early medications I listed. so a friend advice me to go teaching hospital were I can see a specialist. my question here is now that I have been on medication for a year without knowing my viral load what is d implication ?
BACKGROUND: Nucleoside analogues such as lamivudine for chronic hepatitis B have an excellent safety profile while patients are on therapy but reactivation flares occur in 19-50% of patients after stopping therapy, some of whom develop liver decompensation. AIMS: To describe and report three cases who developed fatal hepatitis B reactivation after stopping nucleoside analogue therapy.
I am a 26 year old male having hbsag and hbeag=+ve,hbv dna =1070 iu/ml(Taqman) but my LFT results are normal(sgpt=37,sgot=33).My doctor has asked me to take lamivudine 100 mg for 6 months or until hbv dna becomes -ve.My mom is taking lamivudine for the last 7 months after her hbv dna crossed 8 lacs iu/ml.Probably I have been infected from my birth.Is it possible for both of us to completely cure Hep. B after taking lamivudine.
The expiry date on the bottle says 01-2011.. Is this bad that I used the eye drops three weeks after it was suppose to be discarded? I only used three quaters of the bottle. I paid a little over fifty dollars for this little 5 mL bottle.... But what can you do....
1. I am HBV carrier, and I am also under treatment with taking lamivudine 100mg daily. Will this impact the result? Will lamivudine/HBV virus cause false negative?
2. Because I am taking lamivudine daily, will this cause the delay of seroconversion. I think the test was done about 18 months after events that I thought maybe risky.
3. My test is Combo TypeI/II antibody and p24 antigen QUAL CMIA. Is it reliable?
4. My HBV DNA level is sometimes undetectable, but sometime a few hundreds.
I am a 26 year old male having hbsag and hbeag=+ve,hbv dna =1070 iu/ml(Taqman) but my LFT results are normal(sgpt=37,sgot=33).My doctor has asked me to take lamivudine 100 mg for 6 months or until it becomes -ve.My mom is taking lamivudine for the last 7 months after her hbv dna crossed 8 lacs iu/ml.Probably I have been infected from my birth.Is it possible for both of us to completely cure Hep. B after taking lamivudine.
I was examined by my first doctor and advice me that I am not qualified for medication but my employment requires to pass this Hepa B case so I look for another doctor that could give me something for medication.. The doctor and give me Lamivudine(Zeffix)..
My question is; Is there someone in this forum that had experience with this level of UI/ml that been cured and how long?.. My employeer is waiting for my respond but I cant give them exact or approximate date when will cured..
Epivir=Lamivudine, said to be very safe for husband and wife who wish to have children. But do you have to choose Lamivudine as first-line treatment with its high resistance profile?
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