stop lamivudine immediately or switch to tenofovir, it is decades now lamivudine is not used because it can lead to cytopatic hbv mutations that cannot be control with any medication leading to cancer and cirrhosis despite hbsag negative, hbvdna undetectable and normal ast-alt, another reason not to use lamivudine is that it is even totally useless on hbv
the hbsag of the virus mutates to a form where the virus destroy cells directly even without replication
hbv cure is achieved only by sequen
I am not a doctor but i can tell you lamivudine is the worst drug for hbv and just make damage.
BACKGROUND: Nucleoside analogues such as lamivudine for chronic hepatitis B have an excellent safety profile while patients are on therapy but reactivation flares occur in 19-50% of patients after stopping therapy, some of whom develop liver decompensation. AIMS: To describe and report three cases who developed fatal hepatitis B reactivation after stopping nucleoside analogue therapy.
In 2014 I did a pcr and result was 700iu/ml, 2015 pcr was 1380iu/ml and just did another 3 days ago with result 101000 iu/ml, which prompted me to see a doctor. He prescribed for me lamivudine 100mg for 6months. My question is, is this the appropriate drug considering I have used this drug 10 yrs ago and also considering other combination options available today.
My doctor suggests that I participate in the drug trial of Tenefovir (Viread) versus Tenofovir in combination with Emtricitibine (Truvada). I have chronic Hepatitis B and Lamivudine resistance last year. He gave me a document to read and I did a bit of research on internet on the side effect. My concern is the side effect especially on Kidney. Could you give me some advice if I should participate in the drug trial or stay with my current medicine Hepsera.
However, PEP always is comprised of combination therapy; neither lamivudine nor any other drug, used alone, has been studied. Doing so risks getting infected with a drug-resistant strain of HIV, so it could actually make things work.
2) It just doesn't. No medical condition has any such effect on HIV testing. It has to do with the complexities of the immune system. I'm not enough of an expert in that arena to give you a detailed biological explanation.
lamivudine is not a hbv drug anymore and it is useless on hbv so you have just wasted money, all antivirals are useless on hbv infection, they can only lower replication to lower liver damage but most hbv carriers have even no liver damage so look for an expert liver specialist to guide you or check all forum posts
the only drugs to use safely to block liver damage are: interferon, tenofovir, entecavir.
there is no excuse we have internet and you can be on the moon and get all the info
this said that tenofovir is the only drug that can work on hbv for you due to your good doctor it is also the less toxic drug, the cheapest, the most potent with no resistance and the most studied.
10.300 copies/ml . I got lamivudine 100 mg /day vitamine E 4oo ui /day, orange juice everyday 50 cc/day ,and others fruits,2 months later my blood test showed DNA/HBV/PCR negative (<200 copies ),checked regularly every 3 months untill now still negative level. SGPT 75- 90 ui/ml constantly,never down a normal range,since 2008 March untill now. HBsAg negative level ,HBsAb negative level ,others test are normal levels .Is i got recovery from Hepatitis B ?
So best not to use Lamivudine as it has very high drug resistance rate. Usually Lamivudine has very few side effects, so it is unlikely to cause all the problems you are experiencing.
no tenofovir is not toxic, since adefovir was a failed drug for both hiv and hbv, drug makers tried to make a lot of disnformation and delay approval of tenofovir as long as possible.
to do this they took data from hiv carriers which are mainly drug addicts and drug addicts have destroied bodies, destroied immune system and organs already, no need for hiv or tenofovir to have any damage.
My doctor prescribed Lamivudine 100 mg once daily for three months. Pls advice can I continue with the drug.
Dear all, I am a chronic Hepatitis B patient who have drug resistence to Lamivudine and Entecavir, and my Kidney is not good(Creatinine=3.7). Doctor said my only next choice of drug is to use Pegylated Interferon(Pegasys), so my questions are: 1. any other drugs that is suitable for me except Pegylated Interferon?
2. Are side effects of Pegylated Interferon quite serious and hard to handle if I have to use it?
Many thanks for your advice and sharing!
Mike.
"Entecavir should not be used in patients with previous lamivudine resistance, yet it may still be an option in lamivudine-experienced patients in case lamivudine resistance never developed," - http://www.hivandhepatitis.com/hep_b/news/2010/0402_2010_a.
Your post is confusing. The usual definitive test for Hepatitis B positive is the HBsAg test. If you test positive for HBsAg then you are Hepatitis B positive.
In some rare cases, you may test HbsAg negative, but your viral load (hbvdna) is detected, then you have what is known as Occult Hepatitis B.
Most likely in your case, you tested hbvdna "negative" after being on Lamivudine, but you still tested HbsAg positive.
As much as you need this job you must be careful on the choice of drug you make. Lamivudine is not a cure for HBV.
Untill such cure is found supression of VL is the altimate goal.
Good luck and take care.
Epivir=Lamivudine, said to be very safe for husband and wife who wish to have children. But do you have to choose Lamivudine as first-line treatment with its high resistance profile?
Hepatic decompensation was not prevented by lamivudine compared to placebo or entecavir compared to lamivudine in three underpowered trials.
Hepatocellular carcinoma was not prevented in four studies with inadequate size and duration. In one RCT, analysis that adjusted for country, sex, baseline ALT level, Child-Pugh score, and Ishak fibrosis score and excluded five individuals who developed HCC within the first year of the study found a borderline significant effect of lamivudine.
no these drugs make untreatable virus mutants, this was a failure on hiv and hbv and should never be used now
sorry a big mistake i did here, this drug lamivudine make untreatable virus mutants, this was a failure on hiv and hbv and should never be used now.
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