For example, develop resistance to Lamivudine and the wonderful Entecavir takes a hit. Develop resistance to Adefovir and the also wonderful Tenofovir takes a hit.
The last time I saw my doctor he told me that he never heard of someone getting renal problems with Adefovir and that he needed some time to tell me what the next treatment would be (and that I should stay now with lamivudine and Adefovir for 2 more weeks and see what happens to my phosphorous and creatinine levels _Adefovir just one pill every 48hours and lamivudine one pill every day .According to you only TENOFOVIR is good for me . I shouldn't take Baraclude(are you a doctor?
HBV DNA clearance was assessed using assays with different sensitivities to detect HBV DNA. Adefovir and lamivudine increased HBV DNA clearance at end of treatment versus placebo. Entecavir increased clearance versus lamivudine with inconsistent effect size. Lamivudine was less effective than adefovir in lamivudine-resistant patients and less effective than telbivudine in HBeAg-positive patients.
Unfortunately, in 2002 when your wife first started with Lamivudine, antiviral treatment was still somewhat new and probably didn't fully understand what resistance means (and sadly some still don't). And in 2002, Adefovir was approved for treating HepB. Lamivudine has has a poor resistance profile. We know that now but can't turn back the clock.
Now, I am NOT a doctor. But I read that Telbivudine is okay to use during a pregnancy. So ask your wife doctor about that option.
which treatment can I take now that my creatinine is elevated afer being on lamivudine and adefovir for 4years.I'm really frightened please answer me .(my DNA is undetectable and my ALAT ASAT are normal).
The mechanism for resistance is differ from antiviral to antiviral. For example, Lamivudine resistance is more on and off. Adefovir is more gradual. Unless you research this area, it's hard to know what exactly is happening. But we do know all antivirals are at risk for resistance over time. And since you are 40 with early cirrohsis, you need the antiviral to stay working for another 30 years or so without resistance, that is a tough goal.
once the lamivudine has been started it is difficult to discontinue it without changing it to another medication. it is possible that you have developed resistance and may need to check a viral level and if (+) be switched to another medication. Resistance is very common with lamivudine use. a CT scan or U/s should also be checked.
Even when lamivudine was resumed, it did not stop the rise in ALT, which then down eventually, but the bilirubins did not. May be compensated cirrhosis patients should never stop therapy, and those on lamivudine should switch to a drug with a higher barrier to mutation?
The Hong Kong-based study involved 252 NUC-experienced patients who switched from treatment with other antiviral agents, such as lamivudine and adefovir dipivoxil, to TDF (300 mg/day) between 2009 and 2013, primarily due to drug resistance. Of these, 152 had persistent viraemia at the time of the switch while the remaining 100 had undetectable HBV DNA.
At a median of 22 months, 214 (84.
by the way change doctor right away and if possible sue him for the damage due to using useless lamivudine
start tenofovir as soon as possible because it is the only antiviral which works on lam resistance and check all old forum posts to understand how this doctor can be a killer of patients, an hbsag mutation induced by lamivudine and adefovir is directly cytophatic, it means it damages the liver from inside the cells even if hbvdna is undetactable and ast/alt normal and it has a very high r
you can use entecavir or any other antiviral after using lamivudine you have only tenofovir left that works, entecavir will create a monster mutant virus with other 4-8 or more mutations
I was wondering what is the difference between 0.5 mg and 1mg in regards to resistance. Will 0.5 mg of entecavir cause resistance in patients who never have been on any nucs and no polymerase resistance detected vs 1mg. My doctor wants me to take 1mg vs 0.5 mg but I have been been on any nucs and show no resistance to any nucs during genotype testing.
Patients were treated with NAs therapy (lamivudine, adefovir, telbivudine, entecavir and tenofovir) for at least 2 years. qHBsAg was performed every 6 months.
Results
Our results showed a significantly greater qHBsAg decline after 2 years in patients treated with tenofovir (0.45 logIU/ml) than in patients treated with telbivudine (0.12 logIU/ml; P < 0.001).
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Your Consultant wants you to stay on the Lamivudine and Adefovir until July 09 as this will be a year from when you sero-converted from being E antigen positive to E antigen negative and developed E antibodies.
We cannot determine whether you will become an inactive carrier of Hepatitis B until you have stopped the medication and we have followed you up for a while to see what happens.
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