Imiquimod patent

Common Questions and Answers about Imiquimod patent

aldara

Avatar m tn Why? Gilead loses the patent on Viread in 2017/2018. Their cash cow will have run its course and they will be more than happy to release this drug to continue to reap the money for HBV treatment. There is one thing I remember Dr. Gish telling me that I won't forget. He said "you know Gilead is working on a drug that will make it so you don't have to take Viread for ever. It's kind of odd that they'd be working on a drug that will eliminate their Viread income". Not really.
Avatar m tn Stimulation with TLR7, TLR8 and TLR9 agonists did not significantly induce IP-10 or IL-6 production and, with the exception of imiquimod, did not inhibit HBV replication. Interestingly, the antiviral response induced by imiquimod was independent of innate immune activation, suggesting an additional mode of action that should be further investigated.
Avatar m tn catalog_no=IMG-2208 Imiquimod and resiquimod as novel immunomodulators http://jac.oxfordjournals.org/content/48/6/751.
Avatar m tn they should just give it out now. We have to demand it guys. Not only this but demand better more open clinical trials, that involve more then just six people. The way they run clinical trials is very tricky. Clinical trial recruiters act like sales people. They take only certain people, and don't really explain anything. I am so disappointed. It seems like if you ask one wrong question, or ask too many questions, they wont take you.
Avatar m tn I mean they give interferon treatment at home and chemotherapy with minimal monitoring - and yet they worry about with something as imiquimod. This imiquimod GS9620 main ingredient i am being told knocks out HPV virus. Very effective against Hep C too. That is what people that worked as biologists that studied viruses report. Information is out there. And these companies with their financial backing must have a great idea on what it really takes.
Avatar m tn i d say no effect from ezetimibe both on bile acid and hbsag for now 16 oct 2012 hbsag 3687iu/ml blip of hbvdna detected 31iu/ml alt 42 etv+tdf+imiquimod suppository, imiquimod suppository stopped jan 8th 2013 when starting ezetimibe jan 01 2013 started 10mg (40mg on some days) of ezetimibe plus etv+tdf jan 10 2013 hbsag 4207iu/ml feb 01 2013, started daily ezetimibe 50mg, alt 31 feb 28 2013, hbsag 3644iu/ml, hbvdna undetactable mar 13 2013, alt 30 mar 25 2013 biliary acid 1.
Avatar m tn please comment on these results, i think that monthly hbsag quant may confirm if we are having a good result from ezetimibe, we have only one thing certain from 2009 to 2012 hbsag stable from 4200 to 7300 no matter what we tried (alinia or imiquimod) would you also add intf to this combo tdf+etv+ezetimibe since imiquimod too failed?
Avatar m tn Did you read the dosing in there. It's far dorm good news. 2mg/kg. it would be at least over 100mg per person, and in the human study 12mg was the highest they gave which had similar sides as interferon.
Avatar f tn Immune inhalers such as Zadaxin But Myrcludex is a sort of same half fix solution as 9620 (Imiquimod) it will for sure will get once chances better to clear HBV.. but the question remains still - how long will one have to take it so liver cells regenerate completely? Will this take 1 year or more?
Avatar m tn Folks over at UCLA Aids center (good doctors there btw) seem to think Truvada is the safest bet to avoid all resistance period. truvada is just marketing for patent, tdf is the first to lose patent and truvada the last. tenofovir has no resistance for hbv because even if there is resistance to tdf the high dose 300mg makes tdf work anyway...so etv resistance wont make any difference to response to tdf.
Avatar f tn most of machines are not accurate in counting vit d accurately the newest and most accurate use something called chemioimmunescence or similar name but you can understand it those are the ones used because the range in updated to normal range 30-100ng/ml (some have still normal range 11-100ng/ml) i have also found a few machines with normal range 30-60ng/ml, but again do not worry too much about those ranges, the latest normal range are 40-100ng/ml unfortunately much scum and influence from dru
Avatar f tn It would be very interesting to see how would Rep 9AC works with Tenofovir; Baraclude and interferon. Or with imiquimod. That is what needed big steps forward.
Avatar m tn But you have to understand if certain finding in science means so much to other people's life, it leaves issues of personal property or patent law. The burden called responsibility will come in. I still thank you for investing for many years and giving us glimps of hopes. It will never changes. If trials fail, there will be nobody to blame you and your company. But I just hope you not to stop or make a delay for funding issues that can be solved.
Avatar m tn yes that s vit d and 55ng/ml is normal/optimum range 2years is very very unlikly, once you reach hbsag less than 100iu/ml (the lower the better) you may stop intf and continue to clear normal intf, not peg, costs less and vietnam has both versions generic and very cheap, also imiquimod may be able to keep intf but we have to wait my tests results
Avatar n tn I read somewhere that they may not allow those drug to come to market until 2017 when the patent of Viread and Barculade will expires. Don't know how far this is true and don't know how effectives are REP9 AC and Myrcludex-B also.
Avatar f tn no it is not approved and it will never get approved because it is too cheap and off patent now but simvastatin is now proved to prevent liver cancer and fibrosis so all hbvers are suggested to use it with ast/alt monitoring do not wait for an approval or a trial noone will pay for it because there is no payback sim is too cheap.
Avatar m tn it is also easier to call them d3 and d2 because the full names are made to make confusion calcipotriol, the one in the study posted for example, is a synthetic form patented as drug, drug makers know all the effects of vitd and tried to patent the natural form too, they are still trying to and being rejected, in the meantime they patented many similar synthetic forms but as long as the natural form is around the business will work partially because they can only force few doctors to prescribe
Avatar m tn I also remember your use of IMIQUIMOD, orally and suppositories, up to the point of suffering substantial inflammatory side effects. Your gfr is still very good and no cause for concern. I assume you will continue Tdf after stopping peginf and observe the hbsag. I sometimes wonder why the Pisa researchers did not let you use the replicor compound in combo with your interferon therapy. In Italy you should be able to obtain it easily from a DNA synthesizing company.