Fenofibrate in combination with a Statin drug can cause severe Rhabdomyolysis. I know because I have gone through it. My muscle pain got so severe that I couldn't even move my arms and I wound up in the ER with kidney (also a muscle) pain so severe, I was climbing the walls.
Your numbers are high, but you need to look at the breakdown. First off, your TGL's should be under 150. Not hard, just cut out the empty carbs like breads, sugars, pastas etc. Also, drinking will elevate your TGL's so don't over do it. You could start on a Fenofibrate like Tricor to lower your TGL's it works well. A statin will not really do that much.
There is no problem with taking a fenofibrate and a statin, it is perfectly safe, I take them both myself. There are possible side effects when taking a fibrate and a statin, you should ask you doctor to be sure.
Ever since I started taking Zetia and Fenofibrate together as recommended by my DR, I have put on pounds, am more bloated around the belly,a nd have persistent chest pains. I noticed this has occurred ever since I have been on cholesterol lowering meds, but is more noticeable in the past year with the new combination of drugs. I mentioned this to my DR and he said I need the drugs because of my High Cholesterol. What do you think?
You don’t mention dose and you make no mention of any side effects. Both drugs in Rosvin F (statin and fibrate) are generally well tolerated. Neither are drugs one takes “for a month.” Rather, they are lifetime drugs that will keep you in tip-top CV health with more benefit correlating with duration of treatment. If you discontinue treatment, all your lipid levels will return to where they were (unless you have made HUGE lifestyle changes).
It is easy to find information regarding drug-drug interactions for omeprazole (Prilosec) and atorvastatin (Lipitor). The omeprazole appears to increase the bioavailability of the statin, increasing the risk of side effects. Does this mean that the interaction is like taking a higher dose of the statin, which would provide benefit for someone like me who only takes a low dose (10mg atorvastatin daily) and has no statin tolerance issues?
I've never heard of high serum cholesterol having any affect on a surgical procedure or the outcome. Having said that, if he's not on a statin they could put him on one before the surgery, if for no other reason then for it's anti-inflammatory properties. Either way, he needs to get the number down. To lower TGL's, cut out all empty carbs like breads, pastas and sugar and if he is a drinker, he needs to stop as alcohol metabolizes as sugar and has a huge impact on TGL's.
s a low dose, but there appears to be a potential moderate interaction, possibly myopathy and shortness of breath. I called the pharmacist and he said that unless I was taking a higher simvastatin dose (>50mg), I shouldn't have a problem. Heck, I'm only 39yo and in good shape and don't want to even take the simvastatin alone since the potential side effects scare the crap out me, not to mention the combo.
I am now 67 and have tried two different popular statins( lipitor and crestor which did lower LDL about 50 pts but also lowered HDL). I could not tolerate either statin because of personality changes ie: anger and irritability all the time and severe cognitive issues with memory, reasoning and being able to focus. After stopping each statin, it has taken me longer to get back to normal mentally. It is amazing how much better I feel now that I have been off of them for 4 mos.
I took lipitor for twenty years without problems until menopause and the dose was raised from ten to twenty mg. I have gone off and on all statin drugs and recently have been trying generic liptor. I have muscle aches again and headaches this time. Is there anything esle besides statins I can try? I have lost twenty-five pounds and my cholesterol has gone from338 to 228. I think that the lipitor is making me very uncomfortable and that I really can not tolerate it.
My cardiologist has prescribed an increasing dosing regimen of colestipol granules to help lower my LDL level. Here are my last two most current labs from before I started the colestipol. I eat a lower fat diet, exercise by walking 40 minutes 5-6 times per week, don't smoke, control borderline hypertension with 5mg lisinopril daily, have a BMI of 30 but don't have enough self control to lose any weight.
I take both Tricor and a statin, Simvastatin. There are no issues taking a fenofibrate such as Tricor and a statin. The problem comes in when taking a fibrate and a statin. The combination have worked very well for me.
I have noticed since I began taking fenofibrate that I experience cloudy urine after I eat certain foods. It only happens the first time I uninate after eating these foods and becomes clear thereafter. It seems that it is triggered with creamy and greasy foods. Is there cause for concern?
Thank you.
I think they have concluded that neither do Zetia, except when used with a statin, so it is the statin doing the work. I also think Welchol has been shown to not reduce cardiac events too. not sure. I am on Repatha. Third bi weekly shot. have about 1/3 of the severity of symptoms that I had on statins. headache, muscle aches. may put up with it and may not. just keepin on keepin on for now. Will see if this gets better, worse or stays the same.
Most importantly, the adverse effect is related to the dose, the specific statin, and drug-drug interaction. For example, the higher the dose, the higher the risk for myalgia. In addition, the risk of myalgia ranges from 5.1% with fluvastatin (Lescol), 10.9% with pravastatin (Pravachol), 14.9% with atorvastatin (Lipitor), and 18.2% with simvastatin (Zocor). And you have been on both atorvastatin (Lipitor) and pravastatin (Pravachol).
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