Ezetimibe cancer
Common Questions and Answers about Ezetimibe cancer
vytorin
PSA 9.1,Gleason 8, aggressive Prostate cancer age 50, RP 1999 PSA 18 prior to surgery, recurrent after 18 mos., 3 years of ADT, 2006 bilateral orchiectomy, cholesterol levels, currently taking lipitor 40, blood sugar elevated, probably metabolic syndrom. What is best course of treatment?
This discussion is related to <a href='http://www.medhelp.org/posts/show/270487'>Radiation treatment options for recurrent prostate cancer</a>.
also statins like simvastatin were reported to boost response a little but better not mix 2 statins, in a report researchers of ezetimibe effect on hbv and hcv suggested the use of ezetimibe with interferon but without simvastin
ezetimibe dose is 10-20mg daily but human trials with dose 50mg daily for a limited time did not find any sides or toxicity
The FDA-approved drug ezetimibe (sold under the trade-name Zetia) is readily available and perfectly targeted to the receptor, Sainz said, so the researchers had an ideal method for testing NPC1L1's involvement in HCV infection.
The researchers showed that ezetimibe inhibited HCV infection in cell culture and in mice transplanted with human liver cells. And, unlike any currently available drugs, ezetimibe was able to inhibit infection by all six types of HCV.
A recent paper studied the effect of most FDA approved drugs on the inhibition of NTCP, the now known entry receptor for HBV. Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg.
no study for its activity on hbv, we do know it has activity but the trial has never started
simvastatin lowers hcc 50% and prevents fibrosis/cirrhosis so it is indicated on all hbver, this has thousands of pateints studied for decades to find this data on hcc
you better use simvastatin instead other statins, also ezetimibe has in vitro effect on hbv so these are the best choices on hbvers
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Fatty liver, which often accompanies obesity and type 2 diabetes, frequently leads to more serious conditions including cirrhosis and liver cancer. The condition affects some 10 to 24 percent of the general population, according to a 2003 study in GUT, an international journal of gastroenterology and hepatology.
There was an in vitro study on ezetimibe inhibiting HBV DNA production. The ed50 was fairly low and in a similar range as lamuvidine. So it looked very interesting. But in an in vitro study you have a constant exposure to the drug, which is impossible to achieve in vivo. And the cells used are not the same as regular hepatocytes in human liver, with many differences in gene expression and cellular physiology.
About two years ago my doctor added ezetimibe to my regimen. It has been lowering my bad cholesterol how ever the first of this month I missed taking them for about a week and for the first time in years I felt less fatigued. I do have Fibromyalgia which is usually the cause of my fatigue, but this is a different type of fatigue. I have not restarted either of the cholesterol meds back because I have felt so much better. I know I need to talk to my doctor about it.
I had very high cholesterol, due to familial hypercholesterolemia, and living on just salad for weeks did nothing for the levels. Statins have worked wonders in bringing the levels down but I also take Ezetimibe which slows absorption of fats through the gut lining. Now I can basically eat what I want and my cholesterol levels are always within the range required.
Cholesterol in the blood is not the cause of disease, it's like a side effect from the initial problem.
If this fails, which it did with me, then your statins need a turbo boost but from a different angle which will not affect the liver. We consume around 25% of fats through food and so a good drug such as Ezetimibe works wonders with statins because it helps block fat absorption through the gut lining. This method dramatically increased my HDL and lowered my LDL and trigs to rock bottom. Actually after starting this regime, my disease didn't increase for a year and has remained static.
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