Ezetimibe studies
Common Questions and Answers about Ezetimibe studies
vytorin
no study for its activity on hbv, we do know it has activity but the trial has never started
simvastatin lowers hcc 50% and prevents fibrosis/cirrhosis so it is indicated on all hbver, this has thousands of pateints studied for decades to find this data on hcc
you better use simvastatin instead other statins, also ezetimibe has in vitro effect on hbv so these are the best choices on hbvers
Gastrointestinal Unit, Massachusetts General Hospital
Abstract
Hepatitis C associated hypolipidemia has been demonstrated in studies from Europe and Africa. In two linked studies, we evaluated the relationship between hepatitis C infection and treatment with lipid levels in an American cohort and determined the frequency of clinically significant posttreatment hyperlipidemia. First, a case-control analysis of patients with and without hepatitis C was performed.
also statins like simvastatin were reported to boost response a little but better not mix 2 statins, in a report researchers of ezetimibe effect on hbv and hcv suggested the use of ezetimibe with interferon but without simvastin
ezetimibe dose is 10-20mg daily but human trials with dose 50mg daily for a limited time did not find any sides or toxicity
A recent paper studied the effect of most FDA approved drugs on the inhibition of NTCP, the now known entry receptor for HBV. Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg.
You could consider going for a higher dose of Lipitor, another way to go is to consider taking a drug that limits cholesterol absorption such as Ezetimibe. There is a combination drug Simvastatin and ezetimibe that may be better in controlling cholesterol. Discuss these drugs with your doctor.
Best of luck to you. Stay positive.
I had very high cholesterol, due to familial hypercholesterolemia, and living on just salad for weeks did nothing for the levels. Statins have worked wonders in bringing the levels down but I also take Ezetimibe which slows absorption of fats through the gut lining. Now I can basically eat what I want and my cholesterol levels are always within the range required.
Cholesterol in the blood is not the cause of disease, it's like a side effect from the initial problem.
Here's the rest of the story;
"The memory loss issue was more anecdotal from adverse event reporting and not from formal studies, the FDA said, adding that there was no proof that the problem was caused by statins but that it wanted people to be aware of the possibility.
One safety warning long associated with the class of medicines will be reversed, the FDA said.
ALS is a progressive motor neuron disorder with symptoms such as difficulty walking or standing, difficulty with fine motor skills and muscle paralysis. The FDA is examining the feasibility of performing additional epidemiologic studies to further examine the incidence and clinical course of ALS in patients taking statins.This is something you may wish to discuss with your doctor also.
Hello Chiari world!
I was diagnosed with Chiari in May. Now two of my cousins, my mom and brother have all be diagnosed with it as well. We are joining a genetics study and are curious if any of you others out there have joined any studies. We would like to know what the Pro's and Con's were/are. We feel that since so many of us have been diagnosed in the last three months that our family may be able to help future families and our future generations by joining the study.
I was wondering if anyone knows of any free syringoma studies being conducted in southern california. Your help is greatly appreciated.
It remains unclear whether hepatitis B virus (HBV) genotype has an influence on treatment response -- as is the case for hepatitis C virus (HCV) -- due to inconsistencies across studies and failure to account for differences in race/ethnicity, according to a report in the March 2010 Journal of Hepatology.
It is well known that viral genotype has a major impact on response to interferon-based therapy for hepatitis C, but it is unclear whether this is also true for hepatitis B.
I have been recently working on some clinical studies on anxiety and I was wondering if anybody knew of any clinical support services? I have looked into a few and came across some that sound pretty good. I was wondering if anybody has ever worked with TransPerfect Trial Interactive before? I checked out their website, TrialInteractive, and they seem pretty solid but I would like to hear other people's take on it. What do you guys think? or does anybody have any other suggestions?
Hi, I'm in Knoxville Tn, and I'm looking for information on the trail studies for Hep C treatment for my mom. Does anyone have any suggestions on where to start?
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