Efavirenz intermediates
Common Questions and Answers about Efavirenz intermediates
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Treatment with Flavocoxid or ETV or with drugs combination started 3 hours after transfection and was renewed every other day for 5 days. Total HBV replicative intermediates, viral transcripts and cccDNA levels were evaluated in untreated and treated HepG2 cells by quantitative real-time PCR, Southern and Northern blots experiments. To analyse the epigenetic modulation of HBV cccDNA the cccDNA-ChIP assay was applied to untreated and treated cells.
I have 20 years and I have HIV positive person. I drink medicines already 4 months. I use drugs Truvada and Efavirenz Teva. Please tell me how to code your disease treated? Whether you are at injection instead of pills?
Are there still any evidence of efavirenz teratogenicity in human studies especially on the neuro tube defect
1 hours ago I had protected sex with a sex worker which ended with a failed condom(punched) and then hour later i went to consult doctor and he prescribed EFAVIRENZ and LAMZID.AM I STIL SAFE?
Since that time, he is receiving HAART with lamivudine-zidovudine-efavirenz twice daily, but he told me that there are some days ( at maximun 3) that he does not take the pills, but most days of the month he is adhering to the treatment. His current viral load is 39,000 copies/ml.
When I realized of him diagnosis, I went to a doctor who gave me profilaxis about 18 hours post-exposure with lamivudine-zidovudine.
I am an HIV + male. 43 on truvada/ efavirenz for 2 year with a count of minus 20(undetectable). I was penetrated twice last week where the condom broke and was NOT replaced. The "top" partner is aware of my hiv status. What are the chances of infection for him and apart from testing what should be done? I am otherwise very healthy, no cuts, blood or aparent bruising was detected. I am freaking out for him.
My doctor recently put me on a combination of drugs for PEP, the drugs are lamzid and efavirenz and have very serious side effects. My exposure was licking/sucking a nipple of a non-pregnant HIV positive person. No milk came or blood came out but just had an after taste in my mouth. The act was for 2-3 seconds. What are my chances of getting HIV and are the reported cases of infection in adults, cause I know with babies you can.
s ability to readily detoxify the reactive intermediates or easily repair the resulting damage. Disturbance in this normal redox state can cause toxic effects through the production of peroxides and free radicals that damage all components of cells, including protiens, lipids and DNA. Uric Acid is increased by diet of high fructose intake (corn syrup) and purines found in high amounts or animal food products. Check your diets, my husband drank alot of Mountain Dew and likes to hunt.
Welcome to the forum. Thanks for your question.
Since you are under care with PEP drugs, that doctor or clinic really ought to be the primary source of information about your risk, follow-up plans, etc. Therefore, my comments are brief.
Based on HIV infected persons' sexual histories of when and how they were infected, a CDC study calculated a risk of 1 HIV infection for every 10,000 episodes or performing fellatio on infected partners.
m now under retro-viral treatment (Abacavir, 3TC Lamiduvina, and Efavirenz TM as known in my country), healthy, fit, high CD4 count, undetectable viral load. Recently, I met a person, we kissed and we practiced oral sex on each other. Eventhough I know my condition, and have always tried to avoid people practice fellation on me, he insisted and at the end I agreed. Now, I am really concerned about him. Could he have been infected? Should I tell him to test for HIV?
Hi all,
I have been on a combination of PEP drugs for the past week, the drugs are lamzid and efavirenz. 2 days after taking the drugs I started growing ulcers on my mouth (which has happened before) and I think one in my anus. Could this mean that I am HIV positive? I am very scared. My exposure was sucking a nipple of a woman for less than 2 seconds.
On AUGUST 19TH and AUGUST 20TH, I started taking ARVs which doctor prescribed. (Tenofovir disoproxil fumarate 300mg, Lamivudine USP 600mg, Efavirenz USP 200mg). ARVs made me dizzy, so I stoppped on AUGUST 21ST and AUGUST 22ND. After the viral load result, I started ARVs again. One pill everyday regularly.
4. On AUGUST 29th, I gave blood sample for PCR-HIV QUALITATIVE: (Performed using the Roche COBAS Ampliprep/COBAS Taqman HIV-1 Qualitative Version 2.0 assay.) It turned out negative.
I was given pep (efavirenz+ tenofovir + lamivudine) for 28 days after 48 hours. But I had it for 29 days instead. Now after 57 days I am having flu like symptoms. Runny nose and a bit of sore throat. No fever though. And my abdominal hurts a bit and a little joint pain..
1. What are my chances of contracting hiv from this fingering exposure?
2. Is pep successful if taken at 48 hours of exposure.?
3. Do i need testing? I was tested negative at baseline.
They took my blood test only as a ground zero (for later comparisons). Then doctor prescribed me Zilarvir (2 tablets a day) and Efavirenz (1 tablet a day) to take them one (1) month. The medicines arrived at 15:00 (3:00 PM) and I took both - 17 hours after the incident and high risk exposure.
Doctor told me to come after one month when they will take a new blood test and follow-up.
I am on 300 mg of lamivudine (1 time before bed) 600 mg of efavirenz (1 time before bed) and 300 mg tenofovir (1 time before bed), How effective this for PEP? I am not sure coz I went for an emergency ward which may not have expert on HIV infection. Also I read the label it said for PEP purpouse lamivudine should be used as 150 mg twice daily. Am I right?
After 29 hours of exposure, I took Zifam Eletec (Tenofovir Disoproxil Fumarate 300mg+Lamivudine 300mg+Efavirenz 600mg) and I had been taking it regularly at the same exact time every day (30 days course) which ended on Jan 27, 2022.
1. For my case, may I know the HIV infection risk/possibility for my exposure (because the HIV status of that female is unknown and contact time is short)?
2.
Thanks JB.
to mike1105: thanks.
You say it's a bit tricky to get the "intermediates" right. Since posting I located an old friend out of town(who is a D.D. but no longer practicing) and he told me over the phone several things: 1) he never heard of "intermediates" for the type of denture replacement I described. I had a functioning set of dentures which were there to be used for control prior to the surgery - they were not.
It is probable that these cells could support viral replication because hepatitis B virus DNA replicative intermediates, viral transcripts and HBsAg and HBcAg proteins were detected in most. These findings may be relevant to the initiation of extrahepatic syndromes associated with chronic hepatitis B virus infection such as vasculitis, glomerulonephropathy, neuropathy and dermatitis.
Similarly, extensive analyses of intrahepatic woodchuck hepatitis virus (WHV) and duck hepatitis B virus (DHBV) DNA intermediates under nucleoside analog therapy clearly demonstrated that cccDNA become the predominant form of viral DNA replication intermediates upon long-term suppression of viral DNA replication40 and 41. These findings strongly suggest that cccDNA is the most stable HBV replication intermediate and elimination of cccDNA is the key to cure HBV infection.
Alan McLachlan at the University of Illinois-Chicago, dramatic reductions in viral transcripts, viral replicative DNA intermediates, and intracellular HBV core antigen were observed in the liver after two weekly doses.
Since that time, he is receiving HAART with lamivudine-zidovudine-efavirenz twice daily, but he told me that there are some days ( at maximun 3) that he does not take the pills, but most days of the month he is adhering to the treatment. His current viral load is 34,000 copies/ml.
When I realized of him diagnosis, I went to a doctor who gave me profilaxis about 18 hours post-exposure with Combivir.
Nicotinamide suppressed both HBV DNA replicative intermediates and 3.5-kb mRNA expression. Moreover, nicotinamide treatment also suppressed core protein expression and the secretion of the hepatitis B surface antigen (HBsAg) and the hepatitis B e antigen (HBeAg) in HBV-expressing cell models. Importantly, nicotinamide treatment suppressed serum HBV DNA, HBsAg and HBeAg levels and liver HBV DNA in HBV-transgenic mice.
Hello Teak,
I have a question I'd like to ask you. I engaged in protected vaginal intercourse with a CSW here in a spa in Malaysia. Unfortunately towards the end of the act, my condom broke - I must have had intercourse for about a minute or two before realising. Upon realisation, I immediately stopped intercourse and freaked out. Upon asking the CSW - she assured me that she's HIV negative and that she get's checked every six months in order to maintain employment.
The siRNAs in ARC-520 intervene at the point of DNA transcription, upstream of where nucleotide and nucleoside analogues act, and can deeply knockdown all HBV gene products, including proteins and the viral intermediates necessary to produce viral DNA.
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