apri cirrhosis

My GI did a Fibrosure test and it came back F-4 bridging to Cirrhosis (possible early cirrhosis) and referred me to a Hepatologist. My platetes are at 130, Ast 64, Alt 92 and a viral load of one million two hundred thousand. When I got the news I was very angry and then afraid, I really did not think it would get to this since I feel so healthy.I am in very good shape and exercise all the time, never tired and lots of energy. My new Doc ordered new lab work, scheduled endoscopy and MRI.

5, you have no fibrosis or just a little. If your APRI score is 1.5 or above, you probably have cirrhosis. APRI scores between 0.5 and 1.5 are related to progressive fibrosis stages, like Metavir F1-to-F4. That's all there is to it. It's simple, has a good level of reliability compared to other fibrosis tests, and you can calculate it yourself from your blood tests.

That is, an APRI score of less than 0.5 means no or very slight fibrosis, and an APRI score of more than 1.5 means cirrhosis. The intermediate scores approximate the intermediate fibrosis stages. I have now calculated my APRI score for the seven blood tests done between 2006 and now, and the graph of the scores shows a steady progression from early to later stage fibrosis, which is apparently what has happened. That is, I'm a fast progressor (65 years old, geno 1b, etc.).

s one every five years.The fibroscan is accurate for mild fibrosis F0-F1 or cirrhosis F4,in the middle stages which is where your at it is not very accurate.Same with the fibrosure test. What I suggest is use some non invasive methods and add them together to give a general idea,you can get a fibroscan,do a AST/ALT ratio,a FiB4 score and a APRI index. AST/ALT ratio and FIB4 score you can do at this web site.Just click on calculators. http://gihep.com/?page_id=782 APRI index http://www.

Your #s are great!!!!!!! Are you sure your Cirrhotic? They have a formula that you can use called APRI which can give you an idea of what stage you are based upon your platelet # and ALT score. You can google APRI calculator to find your score. Kinda interesting. On my lab results normal is 150-400 so I don't seem normal yet as I'm still 141. Hoping to see some change at my next appt. Thanks for responding and check out your scores.

There was no evidence that marijuana smoking accelerates progression to significant liver fibrosis (APRI ≥ 1.5) or cirrhosis (APRI ≥ 2; hazard ratio [HR]: 1.02 [0.93–1.12] and 0.99 [0.88–1.12], respectively). Each 10 additional joints/week smoked slightly increased the risk of progression to a clinical diagnosis of cirrhosis and ESLD combined (HR, 1.13 [1.01–1.28]).

Hello dear folks. I would like to know how did or does your liver improve after svr? Especially people with regularly fibroscans.does the improvement show up in the fibroscan,even in those with cirrhosis before treatment.I think it's a very slow process but I've noticed the my fibroscan numbers have gone continuing go down. Apreciate some opinions.

While the “point-of–no–return” along the spectrum of fibrosis and cirrhosis has not been defined, it may occur in the later stages of cirrhosis and reflect the characteristics of local cell populations, the matrix, and particularly the vasculature. Clinical Features of Fibrosis and Cirrhosis Fibrosis per se is asymptomatic and its major clinical importance is the potential for progression to cirrhosis.

[39] Alternate in vitro diagnostic testing for liver fibrosis was subsequently developed, including FibroIndex and Forns index.[38] For identifying cirrhosis, the age-platelet index, APRI and Hepascore have median AUROCs of 0.80 or greater (range 0.80–0.91).[38] Transient elastography, using the FibroScan device (Echosens, Paris, France), is widely used in several European countries and has more recently been adopted in Asia and Canada.

Assessing someone's true liver fibrosis status, via non-invasive markers, has been pursued for quite sometime with varied success. You have used the best known method, earlier on with the liver biopsy, but that is considered way too invasive for many or even most doctors. Fibrosure or Fibrotest (FT) is one of the better non-invasive methods, but it is still too "fuzzy" to be completely relied up on. It's Positive Predictive Value (PPV) is somewhat low (between 0.5 to 0.

Since my earlier note, I have been diagnosed with systemic lupus erythematoses and alpha-1 antitrypsin deficiency (**** variant) this past year. My amino transferases have been elevated for almost thirty years (the time of first measurement). I had asked my doctors for an A1AT deficiency test for a number of years, but it was only performed a week ago after all other tests other than ANA yielded a negative result on many occasions. My alpha 1 levels are 34.

But I am very convened about the fibroscan score. Should I accept this score and the fact that my liver is on fast track to cirrhosis now? Or should I see another doctor?

I never had a biopsy and just had a fibroscan yesterday, and it showed a score of 25. It is well above the Cirrhosis cutoff score of 12 or so. I just want to understand how advanced my cirrhosis is and what the chances of SVR are, given that I understand success rate for Cirrhotics are not high with just SOC. Also, I am a bit confused by the fibroscan score. Wondering if it is reliable, going by other parameters below.

Methods A systematic literature search was performed to identify studies that assessed the association between SVR and cirrhosis regression. The main outcome studied was cirrhosis regression in patients with a SVR as compared with patients without a SVR. Six studies totalling 443 patients were included. Dichotomous outcomes were reported as risk ratios (RR) with 95% confidence intervals (CI).

For the diagnosis of liver cirrhosis, TE performed very well, with diagnostic accuracies of AUROC 0.90, better than those of serum fibrosis markers (AUROC 0.77-0.86) [8]. In an additional study, the accuracy of TE for the diagnosis of significant fibrosis was improved by approximately 10% when TE was combined with serum markers [23]." TE = Fibroscan So no worry my friend...Fibroscan will most likely again show you have F0, or in the worst case F1 which is also no problem...

Common Questions and Answers about Apri cirrhosis

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