Time-updated Cox Proportional Hazards models were used to assess the association between the average number of joints smoked/week
and progression to significant liver fibrosis (
APRI ≥ 1.5), cirrhosis (APRI ≥ 2) or ESLD.
Results. At baseline, 53% had smoked marijuana in the past 6 months, consuming a median of 7 joints/week (IQR, 1–21); 40% smoked daily. There was no evidence that marijuana smoking accelerates progression to significant liver fibrosis (APRI ≥ 1.