Your pharmacist knows what interacts and should have a
list of everything you take, prescription and nonprescription. Just because they are natural does not mean they can be safe with other interactions with other drugs, no matter how harmless.
Second, when you have a stress induced or as with me, stresses induced a manic depression, the naturals, no matter how great during the regular times is completely ineffective but for the sleeping, on controling the disorders problem.