Alendronate mechanism
Common Questions and Answers about Alendronate mechanism
boniva
Until recently, the principal treatment has been resection or fracture repair, although the latter is often palliative at best. However, new insight into the molecular mechanism of fibrous dysplasia has led to the use of bisphosphonates to treat this disease. The authors examined the effects of high-dose oral alendronate (40 mg daily) for 6 months on 3 adult patients with intractable headache due to fibrous dysplasia of the skull. Each patient had disease processes not amenable to surgery.
Until recently, the principal treatment has been resection or fracture repair, although the latter is often palliative at best. However, new insight into the molecular mechanism of fibrous dysplasia has led to the use of bisphosphonates to treat this disease. The authors examined the effects of high-dose oral alendronate (40 mg daily) for 6 months on 3 adult patients with intractable headache due to fibrous dysplasia of the skull. Each patient had disease processes not amenable to surgery.
if the mechanism of action is to decrease osteoclasts (thereby dead bone cells are not removed) - is this helpful to have denser bones made of dead bone tissue? I am thinking it may be better to increase calcium, improve general mineral, Vit D nutrition and get another bone density test as opposed to taking biphosphonates. If my bone density doesn't improve then I will consider taking it for up to 5 years.
Calcium and vitamin D3 supplements are helpful, but in some cases the problem is the mechanism by which bone is created.
Three types of osteoporosis exist and the treatments vary with the etiology,
Idiopathic, with no known cause is uncommon.
Type I, or postmenopausal occurs in women between 51 and 75 years of age. It can occur in men with low levels of testosterone. Estrogen deficiency is a significant cause of bone loss.
I took my first dose of Alendronate and then experience significant muscle pain for the next 4 days. Does anyone know if I should expect this to happen each time I take it or is it something to happen for the first few times until my body adjusts to the medicine?
Do you mean Fosamax (alendronate)? If you do, its for treating bone problems like Osteoperosis by adding bone mass and slows bone loss. I use it for Osteopenia.
The prescription drug Fosamax (the generic is alendronate sodium) is a medication which has been prescribed to hundreds of thousands of postmenopausal women to treat osteoporosis and help increase bone mass thereby reducing the chance of spinal or non-spinal fractures. Fosamax has also been prescribed to increase bone mass in men with osteoporosis. Brand name Fosamax is manufactured in the United States by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
I am also taking Aromasin for bc. Stopped alendronate (I am osteopenic due to 30 yrs of prednisolone and Arimidex) in case this caused the oesophagitis. Would appreciate your advice.
thankyou,i am with contact of my doctor ,he said there is no solution for damaged vertibras,but calcium and vitiman d and alendronate sodium/cholecaiciferol tablets will help spine and bones from further damages but what to do with prednisones i cant stop them because of asthma and taking of them will damage other bones isnt there any other solution instead of prednisones, i know there is nothing accept these because my doctor told me:(
Osteoporosis medications like Raloxifene (Evista), alendronate (Fosomax), risendronate (Actonel) and ibandronate (Boniva) all can cause flu like symptoms in individuals that are taking them. I am not sure what medications you are on, but this could be your problem.
Do any of you know of a well documented scientific study on vaginal-penile (and viceversa of course) transmission mechanism to share with me? That has been wandering my mind and I wanted to get a little educated on it. Please, if any, then paste the URL. Thank ya'll!
He explained that the mechanism of swaloowing is a very complex sequences of involuntary actions initiated by a voluntary one. It seems that the sequence occasionally gets off track and you need to "reboot" the system.
If the inability to swallow persists for a long time, then it is likely abnormal, but the occasional inability to swallow is surprisely common and not to be worried over.
It concerns me because her speech is minimal (we have a speech therapist on board now). Is this a normal coping mechanism? She also does this when dad plays video games, and when he turns it off, she'll open her eyes and uncovers her ears again. Once again is this normal?
In this paper, we demonstrate important parts of this mechanism. Initially, HIV-induced impairment of proliferation was shown to be an active process involving induction of protein tyrosine kinases in both CD4 and CD8 T cells. Furthermore, the impairment of cell proliferation was demonstrated to be linked to induction of the inhibitory protein kinase A (PKA) pathway by HIV proteins.
Also, would it perhaps be possible to add some alendronate, or something else to help her bone density and still be able to benefit from the thyroid medication? Thank you so much!
The mechanism of action of Campral® (acamprosate calcium) Delayed-Release Tablets in maintenance of alcohol abstinence is not completely understood. Originally, several neurotransmitter systems, including GABA, were investigated for a possible role in Campral's mechanism of action. However, recent evidence suggests Campral's main interaction is with the glutamate system. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition.
Within our subconscious mind we retain a primitive mechanism to both remember stress, and control our ability to sleep. When we are in balance we send the appropriate instruction to our subconscious, and the sleep mechanism simply takes over. However when this balance is disturbed the result is sleeplessness. The mechanism which controls sleep is both "reactive" to our desire to sleep and "responsive" to our body's need for sleep.
s, but this has exponentially been exacerbated by Arimidex. For the past 2 yrs I have been taking a weekly bisphosphonate (Alendronate), plus twice daily Calcichew/Vit.D to help prevent further bone loss.
Tamoxifen is prescribed for pre-menopausal patients, the AI's for post-menopausal. As I had a full hysterectomy some 19 yrs ago, I could go straight on to Arimidex.
Oyakawa
I am in my 3rd year of medical school and I was wondering the mechanism of action of steroid injections in the eyelid causing cataracts. It is not an osmotic agent so why does that occur?
thanks so much.
There is no chance of. pregnancy.If you read the mechanism of conception and longevity of sperms outside the body you will realize that there is no chance of conception.
Does this mean that dementia is developed due to alcohol abuse? If, so how chronic use of alcohol affect one's cognitive ability and/or impair SNS??? What is the mechanism of this particular type of dementia?? Could anyone please help with my question?
It is known that the protection from infection in vaccinated persons results not only from the antibody titer, but also quite effectively from the presence of a class 2 T cell response that is extremely sensitive and tends to block access of the virions from the tissue level to the blood stream. This mechanism persists even after AB titers fall below the official threshold.
The same mechanism works in HCV contacts.
Theories of water loss and/or heat loss of the lining of the airways have been proposed as the mechanism of EIB, but recent research suggests that that the mechanism may be more complex than that. For some people, it is the only clinical manifestation of their asthma. The "bronchitis" you get once or twice a year, in truth, may be asthma flare-ups and likely preventable. And, chronic/recurrent rhinitis/sinusitis is commonly associated with asthma.
, duloxetine) has a combination mechanism of action involving serotonin and norepinephrine making it useful in depression and also neuropathic pain.
When a peripheral nerve is injured there is an increase in pain sensitive fibers leading to increase pain recognition. This causes a change in central (i.e., brain/spinal cord) recognition of pain. One major neurotransmitter involved in this is norepinephrine. Cymbalta works to modulate this change.
Everybody has some thyroid antibodies and the antibodies are the normal mechanism to control excessive thyroid hormone levels. An elevated TSH indicates that the thyroid is not producing enough thyroid hormone. Logic suggests that a elevated TSH would be contrary to a Hashimoto's response. If the TSH is elevated the thyroid hormone level is low, there should be no increase of thyroid antibodies.
I am the patient mentioned above.
My boyfriend suffers from this also Conversionn A defense mechanism, operating unconsciously, by which intrapsychic conflicts that would otherwise give rise to anxiety are instead given symbolic external expression. The repressed ideas or impulses, and the psychological defenses against them, are converted into a variety of somatic symptoms. These may include such symptoms as paralysis, pain, or loss of sensory function.
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