The active ingredient, imiquimod, has been shown to
stimulate toll-like receptor 7. Aldara
also induces psoriasis-like lesions when applied to
naive murine skin, and as such is used as a mouse model for psoriasis. Here we find that in naive murine skin, Aldara induces inflammation largely independently of toll-like receptor 7. Surprisingly, inflammasome activation, keratinocyte death and interleukin 1 release also occur in response to the vehicle cream in the absence of imiquimod.