Adverse effects include pain, irritation, soreness, and
mild scarring. Repeated treatments are necessary.
Imiquimod 5% (Aldara
), an immune response modifier, stimulates production of interferon-alfa and other proinflammatory cytokines, inducing a tissue reaction known to be associated with viral clearance from the skin. Apply 3 times per week for up to 16 weeks or nightly for 4 weeks. Clearing can take up to 3 months.
Tretinoin (Retin-A) 0.1% cream can be applied to lesions twice daily.